В библиотеке 1126 научных статей с 1965 года:

1. Immunomodulatory effect of thymoquinone on atopic dermatitis.

Aslam H, Shahzad M, Shabbir A, Irshad S.

Mol Immunol. 2018 Jul 18;101:276-283. doi: 10.1016/j.molimm.2018.07.013. [Epub ahead of print]

Javadi SMR, Hashemi M, Mohammadi Y, MamMohammadi A, Sharifi A, Makarchian HR.

Acta Cir Bras. 2018 Jun;33(6):518-523. doi: 10.1590/s0102-865020180060000006. Free Article

3. Impact of thymoquinone on cyclosporine A pharmacokinetics and toxicity in rodents.

Alrashedi MG, Ali AS, Ali SS, Khan LM.

J Pharm Pharmacol. 2018 Jul 16. doi: 10.1111/jphp.12943. [Epub ahead of print]

4. Black Seed.

Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Free Books & Documents

Shaterzadeh-Yazdi H, Noorbakhsh MF, Samarghandian S, Farkhondeh T.

Kidney Dis (Basel). 2018 Jun;4(2):74-82. doi: 10.1159/000486829. Epub 2018 Feb 14. Review. Free Article

6. Treatment merits of Latanoprost/Thymoquinone — Encapsulated liposome for glaucomatus rabbits.

Fahmy HM, Saad EAES, Sabra NM, El-Gohary AA, Mohamed FF, Gaber MH.

Int J Pharm. 2018 Jul 8;548(1):597-608. doi: 10.1016/j.ijpharm.2018.07.012. [Epub ahead of print]

Firdaus F, Zafeer MF, Ahmad M, Afzal M.

Heliyon. 2018 Jun 20;4(6):e00650. doi: 10.1016/j.heliyon.2018.e00650. eCollection 2018 Jun. Free PMC Article

Zhang M, Du H, Huang Z, Zhang P, Yue Y, Wang W, Liu W, Zeng J, Ma J, Chen G, Wang X, Fan J.

Chem Biol Interact. 2018 Jul 2;292:65-75. doi: 10.1016/j.cbi.2018.06.013. [Epub ahead of print] Free Article

Kabil N, Bayraktar R, Kahraman N, Mokhlis HA, Calin GA, Lopez-Berestein G, Ozpolat B.

Breast Cancer Res Treat. 2018 Jul 3. doi: 10.1007/s10549-018-4847-2. [Epub ahead of print]

Beheshti F, Norouzi F, Abareshi A, Khazaei M, Alikhani V, Moussavi S, Biglari G, Soukhtanloo M, Hosseini M.

Saudi J Kidney Dis Transpl. 2018 May-Jun;29(3):554-566. doi: 10.4103/1319-2442.235184. Free Article

11. Thymoquinone: A novel strategy to combat cancer: A review.

Imran M, Rauf A, Khan IA, Shahbaz M, Qaisrani TB, Fatmawati S, Abu-Izneid T, Imran A, Rahman KU, Gondal TA.

Biomed Pharmacother. 2018 Jun 29;106:390-402. doi: 10.1016/j.biopha.2018.06.159. [Epub ahead of print] Review.

Nassef NAE, El-Melegy MA, Beshay EV, Al-Sharaky DR, Al-Attar TM.

Iran J Parasitol. 2018 Jan-Mar;13(1):89-99. Free PMC Article

13. A Review on Possible Therapeutic Effect of Nigella sativa and Thymoquinone in Neurodegenerative Diseases.

Samarghandian S, Farkhondeh T.

CNS Neurol Disord Drug Targets. 2018 Jul 1. doi: 10.2174/1871527317666180702101455. [Epub ahead of print]

Kou B, Kou Q, Ma B, Zhang J, Sun B, Yang Y, Li J, Zhou J, Liu W.

Oncol Rep. 2018 Jun 25. doi: 10.3892/or.2018.6519. [Epub ahead of print]

Kesen S, Amanpour A, Tsouli Sarhir S, Sevindik O, Guclu G, Kelebek H, Selli S.

Foods. 2018 Jun 27;7(7). pii: E98. doi: 10.3390/foods7070098. Free Article

Vlachojannis C, Chrubasik-Hausmann S, Hellwig E, Vach K, Al-Ahmad A.

Phytother Res. 2018 Jun 25. doi: 10.1002/ptr.6129. [Epub ahead of print]

Mouwakeh A, Telbisz Á, Spengler G, Mohácsi-Farkas C, Kiskó G.

In Vivo. 2018 Jul-Aug;32(4):737-743. doi: 10.21873/invivo.11302.

Xiao J, Ke ZP, Shi Y, Zeng Q, Cao Z.

J Cell Biochem. 2018 Jun 22. doi: 10.1002/jcb.26878. [Epub ahead of print]

Shahin YR, Elguindy NM, Abdel Bary A, Balbaa M.

Environ Toxicol. 2018 Jun 19. doi: 10.1002/tox.22574. [Epub ahead of print]

PMID:
29923357
22.

Thymoquinone Attenuates Myocardial Ischemia/Reperfusion Injury Through Activation of SIRT1 Signaling.

Lu Y, Feng Y, Liu D, Zhang Z, Gao K, Zhang W, Tang H.

Cell Physiol Biochem. 2018 Jun 15;47(3):1193-1206. doi: 10.1159/000490216. [Epub ahead of print]

23.

Protective role of thymoquinone against paraquat-induced hepatotoxicity in mice.

Zeinvand-Lorestani H, Nili-Ahmadabadi A, Balak F, Hasanzadeh G, Sabzevari O.

Pestic Biochem Physiol. 2018 Jun;148:16-21. doi: 10.1016/j.pestbp.2018.03.006. Epub 2018 Mar 13.

PMID:
29891368
24.

Thymoquinone and diallyl sulfide protect against fipronil-induced oxidative injury in rats.

Abdel-Daim MM, Shaheen HM, Abushouk AI, Toraih EA, Fawzy MS, Alansari WS, Aleya L, Bungau S.

Environ Sci Pollut Res Int. 2018 Jun 7. doi: 10.1007/s11356-018-2386-3. [Epub ahead of print]

PMID:
29881965
25.

Early and late preventive effect of Nigella sativa on the bleomycin-induced pulmonary fibrosis in rats: An experimental study.

Poursalehi HR, Samareh Fekri M, Sharifi Far F, Mandegari A, Izadi A, Mahmoodi R, Nematollahi H, Porgholamhosein F, Ghorani V, Samareh Fekri M.

Avicenna J Phytomed. 2018 May-Jun;8(3):263-275.

26.

Thymoquinone recovers learning function in a rat model of Alzheimer’s disease.

Poorgholam P, Yaghmaei P, Hajebrahimi Z.

Avicenna J Phytomed. 2018 May-Jun;8(3):188-197.

27.

Effect of Nigella sativa supplementation on obesity indices: A systematic review and meta-analysis of randomized controlled trials.

Mousavi SM, Sheikhi A, Varkaneh HK, Zarezadeh M, Rahmani J, Milajerdi A.

Complement Ther Med. 2018 Jun;38:48-57. doi: 10.1016/j.ctim.2018.04.003. Epub 2018 Apr 11. Review.

PMID:
29857879
28.

Nigella sativa oil protects against tartrazine toxicity in male rats.

Al-Seeni MN, El Rabey HA, Al-Hamed AM, Zamazami MA.

Toxicol Rep. 2017 Dec 28;5:146-155. doi: 10.1016/j.toxrep.2017.12.022. eCollection 2018.

29.

Thymoquinone Ameliorates Doxorubicin-Induced Cardiotoxicity in Swiss Albino Mice by Modulating Oxidative Damage and Cellular Inflammation.

Alam MF, Khan G, Safhi MM, Alshahrani S, Siddiqui R, Sivagurunathan Moni S, Anwer T.

Cardiol Res Pract. 2018 Apr 1;2018:1483041. doi: 10.1155/2018/1483041. eCollection 2018.

30.

Modulatory effects of some natural products on hepatotoxicity induced by combination of sodium valproate and paracetamol in rats.

Zaky HS, Gad AM, Nemr E, Hassan W, Abd El-Raouf OM, Ali AA.

J Biochem Mol Toxicol. 2018 May 25:e22162. doi: 10.1002/jbt.22162. [Epub ahead of print]

PMID:
29799656
31.

Medicinal herbs in the treatment of neuropathic pain: a review.

Forouzanfar F, Hosseinzadeh H.

Iran J Basic Med Sci. 2018 Apr;21(4):347-358. doi: 10.22038/IJBMS.2018.24026.6021. Review.

32.

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn.

Shanmugam MK, Arfuso F, Kumar AP, Wang L, Goh BC, Ahn KS, Bishayee A, Sethi G.

Pharmacol Res. 2018 Jul;133:213-214. doi: 10.1016/j.phrs.2018.05.004. Epub 2018 May 21. No abstract available.

PMID:
29792914
33.

Chemical properties of thymoquinone, a monoterpene isolated from the seeds of Nigella sativaLinn.

Arroo RRJ, Alfa HH.

Pharmacol Res. 2018 Jul;133:151. doi: 10.1016/j.phrs.2018.05.003. Epub 2018 May 16. No abstract available.

PMID:
29777758
34.

In vitro investigation of antimicrobial activities of ethnomedicinal plants against dental caries pathogens.

Besra M, Kumar V.

3 Biotech. 2018 May;8(5):257. doi: 10.1007/s13205-018-1283-2. Epub 2018 May 14.

PMID:
29765815
35.
36.

Thymoquinone Suppresses IRF-3-Mediated Expression of Type I Interferons via Suppression of TBK1.

Aziz N, Son YJ, Cho JY.

Int J Mol Sci. 2018 May 3;19(5). pii: E1355. doi: 10.3390/ijms19051355.

37.

Antiproliferative and antiapoptotic effect of thymoquinone on cancer cells in vitro.

Kus G, Ozkurt M, Kabadere S, Erkasap N, Goger G, Demirci F.

Bratisl Lek Listy. 2018;119(5):312-316. doi: 10.4149/BLL_2018_059.

PMID:
29749248
38.

Neuropharmacological Potential and Delivery Prospects of Thymoquinone for Neurological Disorders.

Jakaria M, Cho DY, Ezazul Haque M, Karthivashan G, Kim IS, Ganesan P, Choi DK.

Oxid Med Cell Longev. 2018 Mar 20;2018:1209801. doi: 10.1155/2018/1209801. eCollection 2018. Review.

39.

Ameliorating effects of Nigella sativa oil on aggravation of inflammation, oxidative stress and cytotoxicity induced by smokeless tobacco extract in an allergic asthma model in Wistar rats.

Khaldi T, Chekchaki N, Boumendjel M, Taibi F, Abdellaoui M, Messarah M, Boumendjel A.

Allergol Immunopathol (Madr). 2018 May 5. pii: S0301-0546(18)30048-X. doi: 10.1016/j.aller.2018.02.005. [Epub ahead of print]

PMID:
29739684
40.

Thymoquinone protects rat liver after partial hepatectomy under ischaemia/reperfusion through oxidative stress and endoplasmic reticulum stress prevention.

Bouhlel A, Bejaoui M, Ben Mosbah I, Hadj Abdallah N, Ribault C, Viel R, Hentati H, Corlu A, Ben Abdennebi H.

Clin Exp Pharmacol Physiol. 2018 May 7. doi: 10.1111/1440-1681.12961. [Epub ahead of print]

PMID:
29733120
41.

Fingerprint profile and efficacy-associated markers of Nigella sativa oil for geographical origin determination using targeted and untargeted HPTLC-multivariate analysis.

Shawky E, El Newehy NM, Beltagy AM, Abd-Alhaseeb MM, Omran GA, Harraz FM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jun 15;1087-1088:108-117. doi: 10.1016/j.jchromb.2018.04.042. Epub 2018 Apr 30.

PMID:
29730530
42.

Protective effects of Nigella sativa on synaptic plasticity impairment induced by lipopolysaccharide.

Anaeigoudari A, Norouzi F, Abareshi A, Beheshti F, Aaghaei A, Shafei MN, Gholamnezhad Z, Hosseini M.

Vet Res Forum. 2018 Winter;9(1):27-33. Epub 2018 Mar 15.

43.

A Comparative Study of the Effects of Nigella sativa Oil Gel and Aloe Vera Gel on Wound Healing in Diabetic Rats.

Sari Y, Purnawan I, Kurniawan DW, Sutrisna E.

J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18772804. doi: 10.1177/2515690X18772804.

44.

Thymoquinone alleviates arsenic induced hippocampal toxicity and mitochondrial dysfunction by modulating mPTP in Wistar rats.

Firdaus F, Zafeer MF, Waseem M, Ullah R, Ahmad M, Afzal M.

Biomed Pharmacother. 2018 Jun;102:1152-1160. doi: 10.1016/j.biopha.2018.03.159. Epub 2018 Apr 5.

PMID:
29710533
45.

Neuromodulatory Effect of Thymoquinone in Attenuating Glutamate-Mediated Neurotoxicity Targeting the Amyloidogenic and Apoptotic Pathways.

Fouad IA, Sharaf NM, Abdelghany RM, El Sayed NSED.

Front Neurol. 2018 Apr 13;9:236. doi: 10.3389/fneur.2018.00236. eCollection 2018.

46.

Nigella sativa L. and Its Bioactive Constituents as Hepatoprotectant: A Review.

Tabassum H, Ahmad A, Ahmad IZ.

Curr Pharm Biotechnol. 2018;19(1):43-67. doi: 10.2174/1389201019666180427110007.

PMID:
29701149
47.

Antioxidant activity of Nigella sativa Seeds Aqueous Extract and its use for cryopreservation of buffalo spermatozoa.

Awan MA, Akhter S, Husna AU, Ansari MS, Rakha BA, Azam A, Qadeer S.

Andrologia. 2018 Apr 26:e13020. doi: 10.1111/and.13020. [Epub ahead of print]

PMID:
29700838
48.

An investigation on the effect of polyphenolic extracts of Nigella sativa seedcake on physicochemical properties of chitosan-based films.

Kadam D, Shah N, Palamthodi S, Lele SS.

Carbohydr Polym. 2018 Jul 15;192:347-355. doi: 10.1016/j.carbpol.2018.03.052. Epub 2018 Mar 18.

PMID:
29691030
49.

Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats.

Abdelrazek HMA, Kilany OE, Muhammad MAA, Tag HM, Abdelazim AM.

Oxid Med Cell Longev. 2018 Mar 4;2018:8104165. doi: 10.1155/2018/8104165. eCollection 2018.

50.

Thymoquinone protects against cerebral small vessel disease: Role of antioxidant and anti-inflammatory activities.

Guan D, Li Y, Peng X, Zhao H, Mao Y, Cui Y.

J Biol Regul Homeost Agents. 2018 Mar-Apr;32(2):225-231.

PMID:
29685000
51.

The Neuroprotective Effects of Thymoquinone: A Review.

Farkhondeh T, Samarghandian S, Shahri AMP, Samini F.

Dose Response. 2018 Apr 11;16(2):1559325818761455. doi: 10.1177/1559325818761455. eCollection 2018 Apr-Jun.

52.

Therapeutic effect of thymoquinone against lead-induced testicular histological damage in male Wistar rats.

Mabrouk A.

Andrologia. 2018 Apr 16:e13014. doi: 10.1111/and.13014. [Epub ahead of print]

PMID:
29659036
53.

Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells.

Subburayan K, Thayyullathil F, Pallichankandy S, Rahman A, Galadari S.

Cancer Lett. 2018 Jul 10;426:80-97. doi: 10.1016/j.canlet.2018.04.009. Epub 2018 Apr 12.

PMID:
29656006
54.

Influence of Nigella sativa seeds, Rosmarinus officinalis leaves and their combination on growth performance, immune response and rumen metabolism in Dorper lambs.

Odhaib KJ, Adeyemi KD, Ahmed MA, Jahromi MF, Jusoh S, Samsudin AA, Alimon AR, Yaakub H, Sazili AQ.

Trop Anim Health Prod. 2018 Jun;50(5):1011-1023. doi: 10.1007/s11250-018-1525-7. Epub 2018 Apr 13.

PMID:
29654500
55.

Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways.

Chowdhury FA, Hossain MK, Mostofa AGM, Akbor MM, Bin Sayeed MS.

Biomed Res Int. 2018 Jan 31;2018:4010629. doi: 10.1155/2018/4010629. eCollection 2018. Review.

56.

Protective effect of thymoquinone, the main component of Nigella Sativa, against diazinon cardio-toxicity in rats.

Danaei GH, Memar B, Ataee R, Karami M.

Drug Chem Toxicol. 2018 Apr 12:1-7. doi: 10.1080/01480545.2018.1454459. [Epub ahead of print]

PMID:
29648463
57.

The field efficacy of Nigella sativa and Berberis vulgaris methanolic extracts against Haemoproteus columbae.

Razavi SM, Asadpour M, Malekpour SH, Jafari A.

Avicenna J Phytomed. 2018 Mar-Apr;8(2):114-121.

58.

Natural therapeutic approach of Nigella sativa (Black seed) fixed oil in management of Sinusitis.

Mahboubi M.

Integr Med Res. 2018 Mar;7(1):27-32. doi: 10.1016/j.imr.2018.01.005. Epub 2018 Feb 2. Review.

59.

Plants and Surgery: The Protective Effects of Thymoquinone on Hepatic Injury-A Systematic Review of In Vivo Studies.

Tekbas A, Huebner J, Settmacher U, Dahmen U.

Int J Mol Sci. 2018 Apr 5;19(4). pii: E1085. doi: 10.3390/ijms19041085. Review.

60.

Some microbiological, physicochemical and ripening properties of Erzincan Tulum cheese produced with added black cumin (Nigella sativa L.).

Çakır Y, Çakmakçı S.

J Food Sci Technol. 2018 Apr;55(4):1435-1443. doi: 10.1007/s13197-018-3058-5. Epub 2018 Feb 7.

PMID:
29606758
61.

Memory enhancing effect of Nigella Sativa hydro-alcoholic extract on lipopolysaccharide-induced memory impairment in rats.

Norouzi F, Hosseini M, Abareshi A, Beheshti F, Khazaei M, Shafei MN, Soukhtanloo M, Gholamnezhad Z, Anaeigoudari A.

Drug Chem Toxicol. 2018 Mar 28:1-10. doi: 10.1080/01480545.2018.1447578. [Epub ahead of print]

PMID:
29589766
62.
63.

Ameliorative Effect of Camel’s Milk and Nigella Sativa Oil against Thioacetamide-induced Hepatorenal Damage in Rats.

Ahmad A, Al-Abbasi FA, Sadath S, Ali SS, Abuzinadah MF, Alhadrami HA, Mohammad Alghamdi AA, Aseeri AH, Khan SA, Husain A.

Pharmacogn Mag. 2018 Jan-Mar;14(53):27-35. doi: 10.4103/pm.pm_132_17. Epub 2018 Feb 20.

64.

The effects of Nigella sativa L. on obesity: A systematic review and meta-analysis.

Namazi N, Larijani B, Ayati MH, Abdollahi M.

J Ethnopharmacol. 2018 Jun 12;219:173-181. doi: 10.1016/j.jep.2018.03.001. Epub 2018 Mar 17. Review.

PMID:
29559374
65.

Investigation of the effects of thymoquinone on erythrocyte deformability in sepsis treatment which created by cecal perforation in rat.

Bostanci H, Dikmen K, Comu FM, Arslan M, Kucuk A.

Bratisl Lek Listy. 2018;119(3):152-155. doi: 10.4149/BLL_2018_029.

PMID:
29536743
66.

The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.

Johnson-Ajinwo OR, Ullah I, Mbye H, Richardson A, Horrocks P, Li WW.

Bioorg Med Chem Lett. 2018 Apr 15;28(7):1219-1222. doi: 10.1016/j.bmcl.2018.02.051. Epub 2018 Feb 27.

PMID:
29519737
67.

Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms.

Nirumand MC, Hajialyani M, Rahimi R, Farzaei MH, Zingue S, Nabavi SM, Bishayee A.

Int J Mol Sci. 2018 Mar 7;19(3). pii: E765. doi: 10.3390/ijms19030765. Review.

68.

Carcass characteristics, chemical and fatty acid composition and oxidative stability of meat from broiler chickens fed black cumin (Nigella sativa) seeds.

Kumar P, Patra AK, Mandal GP, Debnath BC.

J Anim Physiol Anim Nutr (Berl). 2018 Jun;102(3):769-779. doi: 10.1111/jpn.12880. Epub 2018 Feb 28.

PMID:
29493013
69.

In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa

Fathy M, Nikaido T.

Turk J Med Sci. 2018 Feb 23;48(1):178-186. doi: 10.3906/sag-1701-86.

PMID:
29479981
70.

In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa.

Bensiameur-Touati K, Kacimi G, Haffaf EM, Berdja S, Aouichat-Bouguerra S.

Evid Based Complement Alternat Med. 2017;2017:8427034. doi: 10.1155/2017/8427034. Epub 2017 Dec 12.

71.

Dissecting the Potential Roles of Nigella sativa and Its Constituent Thymoquinone on the Prevention and on the Progression of Alzheimer’s Disease.

Cascella M, Bimonte S, Barbieri A, Del Vecchio V, Muzio MR, Vitale A, Benincasa G, Ferriello AB, Azzariti A, Arra C, Cuomo A.

Front Aging Neurosci. 2018 Feb 9;10:16. doi: 10.3389/fnagi.2018.00016. eCollection 2018. Review.

72.

Effect of guar gum coatings containing essential oils on shelf life and nutritional quality of green-unripe mangoes during low temperature storage.

Naeem A, Abbas T, Ali TM, Hasnain A.

Int J Biol Macromol. 2018 Jul 1;113:403-410. doi: 10.1016/j.ijbiomac.2018.01.224. Epub 2018 Feb 22.

PMID:
29476857
73.

An overview on hepatoprotective effects of thymoquinone.

Noorbakhsh MF, Hayati F, Samarghandian S, Shaterzadeh-Yazdi H, Farkhondeh T.

Recent Pat Food Nutr Agric. 2018 Feb 20. doi: 10.2174/2212798410666180221105503. [Epub ahead of print]

PMID:
29473535
74.

Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes.

Abulfadl YS, El-Maraghy NN, Ahmed AAE, Nofal S, Badary OA.

Neurol Res. 2018 Apr;40(4):324-333. doi: 10.1080/01616412.2018.1441776. Epub 2018 Feb 21.

PMID:
29464986
75.

Hepatic Regeneration and Reno-Protection by Fish oil, Nigella sativa Oil and Combined Fish Oil/Nigella sativa Volatiles in CCl4 Treated Rats.

Al-Okbi SY, Mohamed DA, Hamed TE, Edris AE, Fouda K.

J Oleo Sci. 2018 Mar 1;67(3):345-353. doi: 10.5650/jos.ess17204. Epub 2018 Feb 19.

76.

Effect of Thymoquinone on Reproductive Parameter in Morphine-treated Male Mice.

Salahshoor MR, Haghjoo M, Roshankhah S, Makalani F, Jalili C.

Adv Biomed Res. 2018 Jan 30;7:18. doi: 10.4103/abr.abr_69_17. eCollection 2018.

77.

Analgesic Properties of Nigella Sativa and Eucheuma Cottonii Extracts.

Zakaria A, Jais MR, Ishak R.

J Nat Sci Biol Med. 2018 Jan-Jun;9(1):23-26. doi: 10.4103/jnsbm.JNSBM_131_17.

78.

Renoprotective effect of Nigella sativa against cisplatin-induced nephrotoxicity and oxidative stress in rat.

Hosseinian S, Hadjzadeh MA, Roshan NM, Khazaei M, Shahraki S, Mohebbati R, Rad AK.

Saudi J Kidney Dis Transpl. 2018 Jan-Feb;29(1):19-29. doi: 10.4103/1319-2442.225208.

79.

Enhancement of gut permeation of amoxicillin with Nigella sativa seed extract and its phytochemical screening.

Ali B, Ali M, Amin S, Mir SR.

Chin J Nat Med. 2018 Feb;16(2):125-130. doi: 10.1016/S1875-5364(18)30038-4.

PMID:
29455727
80.

Medicinal Plants from Near East for Cancer Therapy.

Abu-Darwish MS, Efferth T.

Front Pharmacol. 2018 Jan 31;9:56. doi: 10.3389/fphar.2018.00056. eCollection 2018. Review.

81.

Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a’]diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells.

Czajkowska A, Gornowicz A, Pawłowska N, Czarnomysy R, Nazaruk J, Szymanowski W, Bielawska A, Bielawski K.

Biomed Res Int. 2017;2017:9153403. doi: 10.1155/2017/9153403. Epub 2017 Dec 26.

82.

The Effects of Thymoquinone Against Morphine-induced Damages on Male Mice Liver.

Salahshoor MR, Vahabi A, Roshankhah S, Darehdori AS, Jalili C.

Int J Prev Med. 2018 Jan 29;9:8. doi: 10.4103/ijpvm.IJPVM_144_16. eCollection 2018.

83.

Immunomodulatory and Anti-inflammatory Effects of Thymoquinone.

Shaterzadeh-Yazdi H, Noorbakhsh MF, Hayati F, Samarghandian S, Farkhondeh T.

Cardiovasc Hematol Disord Drug Targets. 2018;18(1):52-60. doi: 10.2174/1871529X18666180212114816.

PMID:
29437018
84.

Short and long term modulation of tissue minerals concentrations following oral administration of black cumin (Nigella sativa L.) seed oil to laboratory rats.

Basheer I, Qureshi IZ.

Phytomedicine. 2018 Jan 15;39:56-65. doi: 10.1016/j.phymed.2017.12.022. Epub 2017 Dec 20.

PMID:
29433684
85.

Improvement of antihyperglycemic activity of nano-thymoquinone in rat model of type-2 diabetes.

Rani R, Dahiya S, Dhingra D, Dilbaghi N, Kim KH, Kumar S.

Chem Biol Interact. 2018 Feb 5. pii: S0009-2797(17)31276-0. doi: 10.1016/j.cbi.2018.02.006. [Epub ahead of print]

PMID:
29421519
86.

Protective potential of thymoquinone against peroxynitrite induced modifications in histone H2A: In vitro studies.

Rasheed Z, Altorbag AA, Al-Bossier AS, Alnasser NA, Alkharraz OS, Altuwayjiri KM, Alobaid AS, Alsaif AK, Alanazi YH, Alghidani BA, Alduayji MA, Bu Mozah AA, Alsuhaibani SA.

Int J Biol Macromol. 2018 Jun;112:169-174. doi: 10.1016/j.ijbiomac.2018.01.157. Epub 2018 Feb 26.

PMID:
29414727
87.

Supplementation of Nigella sativa seeds to Barbarine lambs raised on low- or high-concentrate diets: Effects on meat fatty acid composition and oxidative stability.

Cherif M, Valenti B, Abidi S, Luciano G, Mattioli S, Pauselli M, Bouzarraa I, Priolo A, Ben Salem H.

Meat Sci. 2018 May;139:134-141. doi: 10.1016/j.meatsci.2018.01.022. Epub 2018 Feb 3.

PMID:
29413673
88.

A comparative analysis of RAPD and ISSR markers for assessing genetic diversity in Iranian populations of Nigella sativa L.

Hosseini KorehKhosravi S, Masoumiasl A, Dehdari M.

Cell Mol Biol (Noisy-le-grand). 2018 Jan 31;64(1):52-59. doi: 10.14715/cmb/2018.64.1.10.

PMID:
29412794
89.

Thymoquinone alleviates the experimentally induced Alzheimer’s disease inflammation by modulation of TLRs signaling.

Abulfadl YS, El-Maraghy NN, Ahmed AE, Nofal S, Abdel-Mottaleb Y, Badary OA.

Hum Exp Toxicol. 2018 Jan 1:960327118755256. doi: 10.1177/0960327118755256. [Epub ahead of print]

PMID:
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90.

A review of effective herbal medicines in controlling menopausal symptoms.

Kargozar R, Azizi H, Salari R.

Electron Physician. 2017 Nov 25;9(11):5826-5833. doi: 10.19082/5826. eCollection 2017 Nov. Review.

91.

Prophylactic and immune modulatory influences of Nigella sativa Linn. in broilers exposed to biological challenge.

Soliman ES, Hamad RT, Ahmed A.

Vet World. 2017 Dec;10(12):1447-1455. doi: 10.14202/vetworld.2017.1447-1455. Epub 2017 Dec 12.

92.

Thymoquinone as a natural spermostatic substance in reproductive medicine: An experimental study.

Golshan Iranpour F, Fazelian K, Dashti GR.

Int J Reprod Biomed (Yazd). 2017 Oct;15(10):641-648.

93.

The Effects of Hydroalcoholic Extract of Nigella sativa Seeds on Serum Estradiol and Prolactin Levels and obstetric Criteria due to Hypothyroidism in Rat.

Pakdel R, Hadjzadeh H, Sadegh MM, Hosseini M, Emami B, Hadjzadeh MA.

Adv Biomed Res. 2017 Dec 28;6:166. doi: 10.4103/2277-9175.221860. eCollection 2017.

94.

The influence of pulsed electric fields and microwave pretreatments on some selected physicochemical properties of oil extracted from black cumin seed.

Bakhshabadi H, Mirzaei H, Ghodsvali A, Jafari SM, Ziaiifar AM.

Food Sci Nutr. 2017 Nov 20;6(1):111-118. doi: 10.1002/fsn3.535. eCollection 2018 Jan.

95.

Evaluation of the Effect of Topical Application of Nigella sativa on Acute Radiation-Induced Nasal Mucositis.

Çanakci H, Yilmaz AAŞ, Canpolat MS, Şeneldir H, Kir G, Eriş AH, Mayadağli A, Oysu Ç.

J Craniofac Surg. 2018 May;29(3):e279-e282. doi: 10.1097/SCS.0000000000004314.

PMID:
29381633
96.

A Review on the Cosmeceutical and External Applications of Nigella sativa.

Eid AM, Elmarzugi NA, Abu Ayyash LM, Sawafta MN, Daana HI.

J Trop Med. 2017;2017:7092514. doi: 10.1155/2017/7092514. Epub 2017 Nov 22. Review.

97.

Effect of Nigella sativa Seed Extract for Hypertension in Elderly: a Double-blind, Randomized Controlled Trial.

Rizka A, Setiati S, Lydia A, Dewiasty E.

Acta Med Indones. 2017 Oct;49(4):307-313.

98.

Comparative Antitussive Effects of Medicinal Plants and Their Constituents.

Saadat S, Shakeri F, Boskabady MH.

Altern Ther Health Med. 2018 Jan 15. pii: AT5617. [Epub ahead of print]

PMID:
29332022
99.

Evaluation of the Antiproliferative Activity of Some Nanoparticulate Essential Oils Formulated in Microemulsion on Selected Human Carcinoma Cell Lines.

Abd-Rabou AA, Edris AE.

Curr Clin Pharmacol. 2017;12(4):231-244. doi: 10.2174/1574884713666180110144336.

PMID:
29318975
100.

Oral Nigella sativa oil and thymoquinone administration ameliorates the effect of long-term cisplatin treatment on the enzymes of carbohydrate metabolism, brush border membrane, and antioxidant defense in rat intestine.

Shahid F, Farooqui Z, Khan AA, Khan F.

Naunyn Schmiedebergs Arch Pharmacol. 2018 Feb;391(2):145-157. doi: 10.1007/s00210-017-1444-6. Epub 2018 Jan 4.

PMID:
29302711
101.

Thymoquinone restores liver fibrosis and improves oxidative stress status in a lipopolysaccharide-induced inflammation model in rats.

Asgharzadeh F, Bargi R, Beheshti F, Hosseini M, Farzadnia M, Khazaei M.

Avicenna J Phytomed. 2017 Nov-Dec;7(6):502-510.

102.

In vitro activity of Nigella sativa against antibiotic resistant Salmonella enterica.

Ashraf S, Anjum AA, Ahmad A, Firyal S, Sana S, Latif AA.

Environ Toxicol Pharmacol. 2018 Mar;58:54-58. doi: 10.1016/j.etap.2017.12.017. Epub 2017 Dec 17.

PMID:
29289818
103.

Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat.

Mohebbati R, Shafei MN, Beheshti F, Soukhtanloo M, Roshan NM, Anaeigoudari A, Parhizgar S, Hosseinian S, Khazdeir MR, Rad AK.

Saudi J Kidney Dis Transpl. 2017 Nov-Dec;28(6):1270-1281. doi: 10.4103/1319-2442.220880.

104.
105.

Traditionally used herbal medicines with antibacterial effect on Aggegatibacter actinomycetemcomitansBoswellia serrata and Nigella sativa.

Maraghehpour B, Khayamzadeh M, Najafi S, Kharazifard M.

J Indian Soc Periodontol. 2016 Nov-Dec;20(6):603-607. doi: 10.4103/jisp.jisp_12_17.

106.

Thymoquinone Inhibits Virulence Related Traits of Cronobacter sakazakii ATCC 29544 and Has Anti-biofilm Formation Potential.

Shi C, Yan C, Sui Y, Sun Y, Guo D, Chen Y, Jin T, Peng X, Ma L, Xia X.

Front Microbiol. 2017 Nov 28;8:2220. doi: 10.3389/fmicb.2017.02220. eCollection 2017. Erratum in: Front Microbiol. 2018 Feb 20;9:290.

107.

Nigella sativa L. as an alternative antibiotic feed supplement and effect on growth performance in weanling pigs.

Petrujkić BT, Beier RC, He H, Genovese KJ, Swaggerty CL, Hume ME, Crippen TL, Harvey RB, Anderson RC, Nisbet DJ.

J Sci Food Agric. 2018 Jun;98(8):3175-3181. doi: 10.1002/jsfa.8823. Epub 2018 Feb 2.

PMID:
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108.

Oral administration of Nigella sativa oil and thymoquinone attenuates long term cisplatin treatment induced toxicity and oxidative damage in rat kidney.

Farooqui Z, Shahid F, Khan AA, Khan F.

Biomed Pharmacother. 2017 Dec;96:912-923. doi: 10.1016/j.biopha.2017.12.007. Epub 2017 Dec 7.

PMID:
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109.

Nigella sativa oil modulates the therapeutic efficacy of mesenchymal stem cells against liver injury in irradiated rats.

Radwan RR, Mohamed HA.

J Photochem Photobiol B. 2018 Jan;178:447-456. doi: 10.1016/j.jphotobiol.2017.11.037. Epub 2017 Dec 2.

PMID:
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110.

Thymoquinone protects the rat kidneys against renal fibrosis.

Bargi R, Asgharzadeh F, Beheshti F, Hosseini M, Farzadnia M, Khazaei M.

Res Pharm Sci. 2017 Dec;12(6):479-487. doi: 10.4103/1735-5362.217428.

111.

Bioassay-guided Isolation of Neuroprotective Fatty Acids from Nigella sativa against 1-methyl-4-phenylpyridinium-induced Neurotoxicity.

Hosseinzadeh L, Monaghash H, Ahmadi F, Ghiasvand N, Shokoohinia Y.

Pharmacogn Mag. 2017 Oct-Dec;13(52):627-633. doi: 10.4103/pm.pm_470_16. Epub 2017 Nov 13.

112.

Thymoquinone Augments Cisplatin-Induced Apoptosis on Esophageal Carcinoma Through Mitigating the Activation of JAK2/STAT3 Pathway.

Hu X, Ma J, Vikash V, Li J, Wu D, Liu Y, Zhang J, Dong W.

Dig Dis Sci. 2018 Jan;63(1):126-134. doi: 10.1007/s10620-017-4856-8. Epub 2017 Dec 2.

PMID:
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113.

Thymoquinone a Potential Therapeutic Molecule from the Plant Nigella sativa: Role of Colloidal Carriers in its Effective Delivery.

Negi P, Rathore C, Sharma G, Singh B, Katare OP.

Recent Pat Drug Deliv Formul. 2018;12(1):3-22. doi: 10.2174/1872211311666171129121128.

PMID:
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114.

Effect of nanoparticle treatment on expression of a key gene involved in thymoquinone biosynthetic pathway in Nigella sativa L.

Kahila MMH, Najy AM, Rahaie M, Mir-Derikvand M.

Nat Prod Res. 2018 Aug;32(15):1858-1862. doi: 10.1080/14786419.2017.1405398. Epub 2017 Nov 27.

PMID:
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115.

Effects of separate and concurrent supplementation of Nano-sized clinoptilolite and Nigella sativaon oxidative stress, anti-oxidative parameters and body weight in rats with type 2 diabetes.

Omidi H, Khorram S, Mesgari M, Asghari-Jafarabadi M, Tarighat-Esfanjani A.

Biomed Pharmacother. 2017 Dec;96:1335-1340. doi: 10.1016/j.biopha.2017.11.077. Epub 2017 Nov 21.

PMID:
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116.

Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn.

Shanmugam MK, Arfuso F, Kumar AP, Wang L, Goh BC, Ahn KS, Bishayee A, Sethi G.

Pharmacol Res. 2018 Mar;129:357-364. doi: 10.1016/j.phrs.2017.11.023. Epub 2017 Nov 21. Review.

PMID:
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117.

Protective effect of Nigella sativa on 4-nonylphenol-induced nephrotoxicity in Clarias gariepinus (Burchell, 1822).

Kotb AM, Abd-Elkareem M, Abou Khalil NS, Sayed AEH.

Sci Total Environ. 2018 Apr 1;619-620:692-699. doi: 10.1016/j.scitotenv.2017.11.131. Epub 2017 Nov 29.

PMID:
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118.

Nigella sativa improves glucose homeostasis and serum lipids in type 2 diabetes: A systematic review and meta-analysis.

Daryabeygi-Khotbehsara R, Golzarand M, Ghaffari MP, Djafarian K.

Complement Ther Med. 2017 Dec;35:6-13. doi: 10.1016/j.ctim.2017.08.016. Epub 2017 Aug 30. Review.

PMID:
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119.

Apoptotic Effect of Nigella sativa on Human Lymphoma U937 Cells.

Arslan BA, Isik FB, Gur H, Ozen F, Catal T.

Pharmacogn Mag. 2017 Oct;13(Suppl 3):S628-S632. doi: 10.4103/pm.pm_93_17. Epub 2017 Oct 11.

120.

The Effect of Thymoquinone on Nuclear Factor Kappa B Levels and Oxidative DNA Damage on Experimental Diabetic Rats.

Usta A, Dede S.

Pharmacogn Mag. 2017 Oct;13(Suppl 3):S458-S461. doi: 10.4103/pm.pm_134_17. Epub 2017 Oct 11.

121.

Enhancement of memory function by antioxidant potential of Nigella sativa L. oil in restrained rats.

Sadaf S, Emad S, Siddiqui NA, Ghafoor S, Yousuf S, Jabeen B, Haider S, Perveen T.

Pak J Pharm Sci. 2017 Sep;30(5(Supplementary)):2039-2046.

PMID:
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122.
123.

A new fatty acid ester from Nigella sativa var. hispidula Boiss showing potent anti-protein tyrosine phosphatase 1B activity.

Liu X, Aisa HA, Xin X.

Nat Prod Res. 2017 Oct 31:1-5. doi: 10.1080/14786419.2017.1396594. [Epub ahead of print]

PMID:
29086598
124.

Assessment of protective potential of Nigella sativa oil against carbendazim- and/or mancozeb-induced hematotoxicity, hepatotoxicity, and genotoxicity.

Hashem MA, Mohamed WAM, Attia ESM.

Environ Sci Pollut Res Int. 2018 Jan;25(2):1270-1282. doi: 10.1007/s11356-017-0542-9. Epub 2017 Oct 30.

PMID:
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125.

Protective effect of thymoquinone, the active constituent of Nigella sativa fixed oil, against ethanol toxicity in rats.

Hosseini SM, Taghiabadi E, Abnous K, Hariri AT, Pourbakhsh H, Hosseinzadeh H.

Iran J Basic Med Sci. 2017 Aug;20(8):927-939. doi: 10.22038/IJBMS.2017.9116.

126.

Extraction, characterization and bioactive properties of Nigella sativa seedcake.

Kadam D, Lele SS.

J Food Sci Technol. 2017 Nov;54(12):3936-3947. doi: 10.1007/s13197-017-2853-8. Epub 2017 Sep 11.

PMID:
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127.

Microwave-assisted extraction of Nigella sativa L. essential oil and evaluation of its antioxidant activity.

Abedi AS, Rismanchi M, Shahdoostkhany M, Mohammadi A, Mortazavian AM.

J Food Sci Technol. 2017 Nov;54(12):3779-3790. doi: 10.1007/s13197-017-2718-1. Epub 2017 Oct 4.

PMID:
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128.

Potential of Nigella sativa seed aqueous extract in ameliorating quinine-induced thrombocytopenia in rats.

Saadia M, Rehman S, Robin S, Ruby T, Sher M, Siddiqui WA, Khan MA.

Pak J Pharm Sci. 2017 Sep;30(5):1679-1690.

PMID:
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129.

An overview on cardioprotective and anti-diabetic effects of thymoquinone.

Farkhondeh T, Samarghandian S, Borji A.

Asian Pac J Trop Med. 2017 Sep;10(9):849-854. doi: 10.1016/j.apjtm.2017.08.020. Epub 2017 Oct 9. Review.

130.

Effects of nigella sativa on various parameters in Patients of non-alcoholic fatty liver disease.

Hussain M, Tunio AG, Akhtar L, Shaikh GS.

J Ayub Med Coll Abbottabad. 2017 Jul-Sep;29(3):403-407.

131.

Antiproliferative and Apoptosis-Inducing Activities of Thymoquinone in Lymphoblastic Leukemia Cell Line.

Soltani A, Pourgheysari B, Shirzad H, Sourani Z.

Indian J Hematol Blood Transfus. 2017 Dec;33(4):516-524. doi: 10.1007/s12288-016-0758-8. Epub 2016 Dec 8.

PMID:
29075062
132.
133.

Thymoquinone inhibits epithelial-mesenchymal transition in prostate cancer cells by negatively regulating the TGF-β/Smad2/3 signaling pathway.

Kou B, Liu W, Zhao W, Duan P, Yang Y, Yi Q, Guo F, Li J, Zhou J, Kou Q.

Oncol Rep. 2017 Dec;38(6):3592-3598. doi: 10.3892/or.2017.6012. Epub 2017 Oct 2.

PMID:
29039572
134.

Alternative products to treat allergic rhinitis and alternative routes for allergy immunotherapy.

Ipci K, Oktemer T, Muluk NB, Şahin E, Altıntoprak N, Bafaqeeh SA, Kurt Y, Mladina R, Šubarić M, Cingi C.

Am J Rhinol Allergy. 2016 Sep 1;30(5):8-10. doi: 10.2500/ajra.2016.30.4364. Review.

PMID:
29025464
135.

Protective Effects of Nigella Sativaon Acetylsalicylic Acid-Induced Nephrotoxicity in Albino Rats.

Asif S, Malik L.

J Coll Physicians Surg Pak. 2017 Sep;27(9):536-539. doi: 2694.

PMID:
29017666
136.

A nutraceutical combination of Cinnamomum cassia &Nigella sativa for Type 1 diabetes mellitus.

Kaur G, Invally M, Khan MK, Jadhav P.

J Ayurveda Integr Med. 2018 Jan — Mar;9(1):27-37. doi: 10.1016/j.jaim.2017.02.005. Epub 2017 Oct 5.

137.

Therapeutic Potential and Pharmaceutical Development of Thymoquinone: A Multitargeted Molecule of Natural Origin.

Goyal SN, Prajapati CP, Gore PR, Patil CR, Mahajan UB, Sharma C, Talla SP, Ojha SK.

Front Pharmacol. 2017 Sep 21;8:656. doi: 10.3389/fphar.2017.00656. eCollection 2017. Review.

138.

Nigella sativa Oil and Chromium Picolinate Ameliorate Fructose-Induced Hyperinsulinemia by Enhancing Insulin Signaling and Suppressing Insulin-Degrading Enzyme in Male Rats.

Elseweidy MM, Amin RS, Atteia HH, Aly MA.

Biol Trace Elem Res. 2018 Jul;184(1):119-126. doi: 10.1007/s12011-017-1167-z. Epub 2017 Oct 4.

PMID:
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139.

Does posttreatment thymoquinone reverse high-dose atorvastatin-induced hepatic oxidative injury in rats?

Hassan SS, Razzaque A, Ahmad Z, Pazdernik V, Amin SN.

Can J Physiol Pharmacol. 2018 Jan;96(1):51-59. doi: 10.1139/cjpp-2017-0599. Epub 2017 Oct 2.

PMID:
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140.

Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways.

Karandrea S, Yin H, Liang X, Slitt AL, Heart EA.

PLoS One. 2017 Sep 26;12(9):e0185374. doi: 10.1371/journal.pone.0185374. eCollection 2017.

141.

Oral thymoquinone administration ameliorates: the effect of cisplatin on brush border membrane enzymes, energy metabolism, and redox status in rat kidney.

Farooqui Z, Shahid F, Abidi S, Parwez I, Khan F.

Naunyn Schmiedebergs Arch Pharmacol. 2017 Dec;390(12):1271-1284. doi: 10.1007/s00210-017-1428-6. Epub 2017 Sep 24.

PMID:
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142.

Protective effect of thymoquinone against diazinon-induced hematotoxicity, genotoxicity and immunotoxicity in rats.

Danaei GH, Karami M.

Environ Toxicol Pharmacol. 2017 Oct;55:217-222. doi: 10.1016/j.etap.2017.09.002. Epub 2017 Sep 7.

PMID:
28938193
143.

Effect of Topical Application of Black Seed Oil on Imiquimod-Induced Psoriasis-like Lesions in the Thin Skin of Adult Male Albino Rats.

Okasha EF, Bayomy NA, Abdelaziz EZ.

Anat Rec (Hoboken). 2018 Jan;301(1):166-174. doi: 10.1002/ar.23690. Epub 2017 Sep 23.

PMID:
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144.

Protective effect of thymoquinone against lead-induced antioxidant defense system alteration in rat liver.

Mabrouk A.

Acta Biol Hung. 2017 Sep;68(3):248-254. doi: 10.1556/018.68.2017.3.2.

PMID:
28901799
145.

Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high fat/cholesterol diet-induced rats.

Ismail N, Ismail M, Azmi NH, Bakar MFA, Yida Z, Abdullah MA, Basri H.

Biomed Pharmacother. 2017 Nov;95:780-788. doi: 10.1016/j.biopha.2017.08.074. Epub 2017 Sep 8.

PMID:
28892789
146.

Thymoquinone, as an anticancer molecule: from basic research to clinical investigation.

Asaduzzaman Khan M, Tania M, Fu S, Fu J.

Oncotarget. 2017 Apr 18;8(31):51907-51919. doi: 10.18632/oncotarget.17206. eCollection 2017 Aug 1. Review.

147.

Antimicrobial effect of different types of honey on Staphylococcus aureus.

Almasaudi SB, Al-Nahari AAM, Abd El-Ghany ESM, Barbour E, Al Muhayawi SM, Al-Jaouni S, Azhar E, Qari M, Qari YA, Harakeh S.

Saudi J Biol Sci. 2017 Sep;24(6):1255-1261. doi: 10.1016/j.sjbs.2016.08.007. Epub 2016 Aug 30.

148.

Plant growth-promoting bacteria elevate the nutritional and functional properties of black cumin and flaxseed fixed oil.

Dimitrijević S, Pavlović M, Maksimović S, Ristić M, Filipović V, Antonović D, Dimitrijević-Branković S.

J Sci Food Agric. 2018 Mar;98(4):1584-1590. doi: 10.1002/jsfa.8631. Epub 2017 Sep 21.

PMID:
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149.

Oral administration of thymoquinone mitigates the effect of cisplatin on brush border membrane enzymes, energy metabolism and antioxidant system in rat intestine.

Shahid F, Farooqui Z, Abidi S, Parwez I, Khan F.

Biomed Pharmacother. 2017 Oct;94:1111-1120. doi: 10.1016/j.biopha.2017.08.044. Epub 2017 Aug 16.

PMID:
28821162
150.

Comparative analysis of essential oil composition of Iranian and Indian Nigella sativa L. extracted using supercritical fluid extraction and solvent extraction.

Ghahramanloo KH, Kamalidehghan B, Akbari Javar H, Teguh Widodo R, Majidzadeh K, Noordin MI.

Drug Des Devel Ther. 2017 Jul 28;11:2221-2226. doi: 10.2147/DDDT.S87251. eCollection 2017.

151.

Thymoquinone prevents endoplasmic reticulum stress and mitochondria-induced apoptosis in a rat model of partial hepatic warm ischemia reperfusion.

Bouhlel A, Ben Mosbah I, Hadj Abdallah N, Ribault C, Viel R, Mannaï S, Corlu A, Ben Abdennebi H.

Biomed Pharmacother. 2017 Oct;94:964-973. doi: 10.1016/j.biopha.2017.08.018. Epub 2017 Aug 12.

PMID:
28810534
152.

Protective Effect of Nigella Sativa Oil on Acoustic Trauma Induced Hearing Loss in Rats.

Culhaoglu B, Erbek SS, Erbek S, Hizal E.

Audiol Res. 2017 Jul 18;7(2):181. doi: 10.4081/audiores.2017.181. eCollection 2017 Jul 18.

153.

Biased activity of soluble guanylyl cyclase: the Janus face of thymoquinone.

Detremmerie C, Vanhoutte PM, Leung S.

Acta Pharm Sin B. 2017 Jul;7(4):401-408. doi: 10.1016/j.apsb.2017.06.003. Epub 2017 Jul 3. Review.

154.

Beneficial effects of TQRF and TQ nano- and conventional emulsions on memory deficit, lipid peroxidation, total antioxidant status, antioxidants genes expression and soluble Aβ levels in high fat-cholesterol diet-induced rats.

Ismail N, Ismail M, Azmi NH, Bakar MFA, Yida Z, Stanslas J, Sani D, Basri H, Abdullah MA.

Chem Biol Interact. 2017 Sep 25;275:61-73. doi: 10.1016/j.cbi.2017.07.014. Epub 2017 Jul 20.

PMID:
28734741
155.

Breastfeeding: A Review of Its Physiology and Galactogogue Plants in View of Traditional Persian Medicine.

Javan R, Javadi B, Feyzabadi Z.

Breastfeed Med. 2017 Sep;12(7):401-409. doi: 10.1089/bfm.2017.0038. Epub 2017 Jul 17. Review.

PMID:
28714737
156.

FTIR spectroscopy of whole cells for the monitoring of yeast apoptosis mediated by p53 over-expression and its suppression by Nigella sativa extracts.

Mihoubi W, Sahli E, Gargouri A, Amiel C.

PLoS One. 2017 Jul 12;12(7):e0180680. doi: 10.1371/journal.pone.0180680. eCollection 2017.

157.

Deodorizing Substance in Black Cumin (Nigella sativa L.) Seed Oil.

Nakasugi T, Murakawa T, Shibuya K, Morimoto M.

J Oleo Sci. 2017 Aug 1;66(8):877-882. doi: 10.5650/jos.ess17001. Epub 2017 Jul 12.

158.

North African Medicinal Plants Traditionally Used in Cancer Therapy.

Alves-Silva JM, Romane A, Efferth T, Salgueiro L.

Front Pharmacol. 2017 Jun 26;8:383. doi: 10.3389/fphar.2017.00383. eCollection 2017. Review.

159.

Effect of thymoquinone on head and neck squamous cell carcinoma cells in vitro: Synergism with radiation.

Kotowski U, Heiduschka G, Kadletz L, Fahim T, Seemann R, Schmid R, Schneider S, Mitterbauer A, Thurnher D.

Oncol Lett. 2017 Jul;14(1):1147-1151. doi: 10.3892/ol.2017.6189. Epub 2017 May 17.

160.

Regressions of Breast Carcinoma Syngraft Following Treatment with Piperine in Combination with Thymoquinone.

Talib WH.

Sci Pharm. 2017 Jul 3;85(3). pii: E27. doi: 10.3390/scipharm85030027.

161.

Protective effect of Nigella sativa oil against acetamiprid induced reproductive toxicity in male rats.

Mosbah R, Djerrou Z, Mantovani A.

Drug Chem Toxicol. 2018 Apr;41(2):206-212. doi: 10.1080/01480545.2017.1337127. Epub 2017 Jul 3.

PMID:
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162.

Thymoquinone as a Potential Adjuvant Therapy for Cancer Treatment: Evidence from Preclinical Studies.

Mostofa AGM, Hossain MK, Basak D, Bin Sayeed MS.

Front Pharmacol. 2017 Jun 12;8:295. doi: 10.3389/fphar.2017.00295. eCollection 2017. Review.

163.

Effects of oral administration of black seed (Nigella sativa) oil on histomorphometric dynamics of testes and testosterone profile in rabbits.

Umar Z, Qureshi AS, Rehan S, Ijaz M, Faisal T, Umar S.

Pak J Pharm Sci. 2017 Mar;30(2):531-536.

PMID:
28649080
164.

Role of Nigella sativa and Its Constituent Thymoquinone on Chemotherapy-Induced Nephrotoxicity: Evidences from Experimental Animal Studies.

Cascella M, Palma G, Barbieri A, Bimonte S, Amruthraj NJ, Muzio MR, Del Vecchio V, Rea D, Falco M, Luciano A, Arra C, Cuomo A.

Nutrients. 2017 Jun 17;9(6). pii: E625. doi: 10.3390/nu9060625. Review.

165.

Immune responses to killed reassorted influenza virus supplemented with natural adjuvants.

Razin MAF, Osman A, Ali MA, Bahgat MM, Maghraby AS.

Acta Microbiol Immunol Hung. 2017 Sep 1;64(3):313-330. doi: 10.1556/030.64.2017.011. Epub 2017 Jun 19.

PMID:
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166.

Protective Effect of a Polyherbal Aqueous Extract Comprised of Nigella sativa (Seeds), Hemidesmus indicus (Roots), and Smilax glabra (Rhizome) on Bleomycin Induced Cytogenetic Damage in Human Lymphocytes.

Galhena BP, Samarakoon SSR, Thabrew MI, Paul SFD, Perumal V, Mani C.

Biomed Res Int. 2017;2017:1856713. doi: 10.1155/2017/1856713. Epub 2017 May 25.

167.

Studies on antihyperlipidemic and endothelium modulatory activities of polyherbal formulation (POL4) and its ingredients in high fat diet-fed rats.

Malik A, Mehmood MH, Akhtar MS, Haider G, Gilani AH.

Pak J Pharm Sci. 2017 Jan;30(1 Suppl):295-301.

PMID:
28625957
168.

The impact of black seed oil on tramadol-induced hepatotoxicity: Immunohistochemical and ultrastructural study.

Omar NM, Mohammed MA.

Acta Histochem. 2017 Jun;119(5):543-554. doi: 10.1016/j.acthis.2017.05.008. Epub 2017 Jun 12.

PMID:
28619287
169.

Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants.

Ayaz M, Sadiq A, Junaid M, Ullah F, Subhan F, Ahmed J.

Front Aging Neurosci. 2017 May 30;9:168. doi: 10.3389/fnagi.2017.00168. eCollection 2017. Review.

170.

Coronary angiogenic effect of long-term administration of Nigella sativa.

Al Asoom LI.

BMC Complement Altern Med. 2017 Jun 13;17(1):308. doi: 10.1186/s12906-017-1795-z.

171.

Th e eff ects of Nigella Sativa extract on renal tissue oxidative damage during neonatal and juvenile growth in propylthiouracil-induced hypothyroid rats.

Mohebbati R, Hosseini M, Haghshenas M, Nazariborun A, Beheshti F.

Endocr Regul. 2017 Apr 25;51(2):105-113. doi: 10.1515/enr-2017-0010.

PMID:
28609286
172.

Insights into the Targeting Potential of Thymoquinone for Therapeutic Intervention Against Triple-negative Breast Cancer.

Barkat MA, Harshita, Ahmad J, Khan MA, Beg S, Ahmad FJ.

Curr Drug Targets. 2018;19(1):70-80. doi: 10.2174/1389450118666170612095959.

PMID:
28606050
173.

Review: Nigella sativa (Prophetic Medicine): A Review.

Ijaz H, Tulain UR, Qureshi J, Danish Z, Musayab S, Akhtar MF, Saleem A, Khan KK, Zaman M, Waheed I, Khan I, Abdel-Daim M.

Pak J Pharm Sci. 2017 Jan;30(1):229-234. Review.

PMID:
28603137
174.

Immune responses to methanolic extract of black cumin (Nigella sativa) in rainbow trout (Oncorhynchus mykiss).

Celik Altunoglu Y, Bilen S, Ulu F, Biswas G.

Fish Shellfish Immunol. 2017 Aug;67:103-109. doi: 10.1016/j.fsi.2017.06.002. Epub 2017 Jun 5.

PMID:
28602677
175.

Evaluation of phenolic profile, enzyme inhibitory and antimicrobial activities of Nigella sativa L. seed extracts.

Topcagic A, Cavar Zeljkovic S, Karalija E, Galijasevic S, Sofic E.

Bosn J Basic Med Sci. 2017 Nov 20;17(4):286-294. doi: 10.17305/bjbms.2017.2049.

176.

Thymoquinone (TQ) inhibits the replication of intracellular Mycobacterium tuberculosis in macrophages and modulates nitric oxide production.

Mahmud HA, Seo H, Kim S, Islam MI, Nam KW, Cho HD, Song HY.

BMC Complement Altern Med. 2017 May 25;17(1):279. doi: 10.1186/s12906-017-1786-0.

177.

Harmful effects of formaldehyde and possible protective effect of Nigella sativa on the trachea of rats.

Sapmaz E, Sapmaz HI, Vardi N, Tas U, Sarsilmaz M, Toplu Y, Arici A, Uysal M.

Niger J Clin Pract. 2017 May;20(5):523-529. doi: 10.4103/1119-3077.183253.

178.

Detection of antibacterial activities of Miswak, Kalonji and Aloe vera against oral pathogens & anti-proliferative activity against cancer cell line.

Amjed S, Junaid K, Jafar J, Amjad T, Maqsood W, Mukhtar N, Tariq K, Sharif M, Awan SJ, Ansari F.

BMC Complement Altern Med. 2017 May 15;17(1):265. doi: 10.1186/s12906-017-1778-0.

179.

Oxidative stress and expression of insulin signaling proteins in the brain of diabetic rats: Role of Nigella sativa oil and antidiabetic drugs.

Balbaa M, Abdulmalek SA, Khalil S.

PLoS One. 2017 May 15;12(5):e0172429. doi: 10.1371/journal.pone.0172429. eCollection 2017.

180.

Neuroprotective effects of Nigella sativa extract upon the hippocampus in PTU-induced hypothyroidism juvenile rats: A stereological study.

Asiaei F, Fazel A, Rajabzadeh AA, Hosseini M, Beheshti F, Seghatoleslam M.

Metab Brain Dis. 2017 Oct;32(5):1755-1765. doi: 10.1007/s11011-017-0025-1. Epub 2017 May 11.

PMID:
28497360
181.

Renal protective effects of thymoquinone against sodium nitrite-induced chronic toxicity in rats: Impact on inflammation and apoptosis.

Elsherbiny NM, Maysarah NM, El-Sherbiny M, Al-Gayyar MM.

Life Sci. 2017 Jul 1;180:1-8. doi: 10.1016/j.lfs.2017.05.005. Epub 2017 May 8.

PMID:
28495515
182.

Protective role of intratympanic nigella sativa oil against gentamicin induced hearing loss.

Edizer DT, Yigit O, Cinar Z, Gul M, Kara E, Yigitcan B, Hayır D, Atas A.

Int J Pediatr Otorhinolaryngol. 2017 Jun;97:83-88. doi: 10.1016/j.ijporl.2017.03.034. Epub 2017 Mar 30.

PMID:
28483257
183.

NEPHROPROTECTIVE AND DIURETIC EFFECT OF NIGELLA SATIVA L SEEDS OIL ON LITHIASIC WISTAR RATS.

Benhelima A, Kaid-Omar Z, Hemida H, Benmahdi T, Addou A.

Afr J Tradit Complement Altern Med. 2016 Sep 29;13(6):204-214. doi: 10.21010/ajtcam.v13i6.30. eCollection 2016.

184.

SELECTIVE INHIBITION OF HEPATITIS C VIRUS REPLICATION BY ALPHA-ZAM, A NIGELLA SATIVA SEED FORMULATION.

Oyero OG, Toyama M, Mitsuhiro N, Onifade AA, Hidaka A, Okamoto M, Baba M.

Afr J Tradit Complement Altern Med. 2016 Sep 29;13(6):144-148. doi: 10.21010/ajtcam.v13i6.20. eCollection 2016.

185.

«Clinicobiochemical evaluation of turmeric with black pepper and Nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study»-a commentary.

Pentapati KC, Gadicherla S, Smriti K.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Jun;123(6):737. doi: 10.1016/j.oooo.2017.02.019. Epub 2017 Mar 16. No abstract available.

PMID:
28478938
186.

Synthesis and characterisation of PEG modified chitosan nanocapsules loaded with thymoquinone.

Vignesh Kumar SK, Renuka Devi P, Harish S, Hemananthan E.

IET Nanobiotechnol. 2017 Feb;11(1):104-112. doi: 10.1049/iet-nbt.2016.0055.

PMID:
28476970
187.

Review-Therapeutic implications of Nigella sativa against cancer metastasis.

Arshad Malik MS, Al Jaouni SK, Harakeh SM, Arshad Malik MF.

Pak J Pharm Sci. 2016 Sep;29(5 Suppl):1881-1884. Review.

PMID:
28476718
188.

In-vitro susceptibility of methicillin-resistant Stayphylococcus aureus to honey.

Hussain MB, Hannan A, Absar M, Butt N.

Complement Ther Clin Pract. 2017 May;27:57-60. doi: 10.1016/j.ctcp.2017.04.003. Epub 2017 Apr 6.

PMID:
28438282
189.

Pattern of Traditional Medicine Utilization among HIV/AIDS Patients on Antiretroviral Therapy at a University Hospital in Northwestern Ethiopia: A Cross-Sectional Study.

Endale Gurmu A, Teni FS, Tadesse WT.

Evid Based Complement Alternat Med. 2017;2017:1724581. doi: 10.1155/2017/1724581. Epub 2017 Mar 22.

190.

The effect of thymoquinone coating on adhesive properties of polypropylene mesh.

Aydin O, Aydinuraz K, Agalar F, Sahiner IT, Agalar C, Bayram C, Denkbas EB, Atasoy P.

BMC Surg. 2017 Apr 17;17(1):40. doi: 10.1186/s12893-017-0239-5.

191.

Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells.

Pang J, Shen N, Yan F, Zhao N, Dou L, Wu LC, Seiler CL, Yu L, Yang K, Bachanova V, Weaver E, Tretyakova NY, Liu S.

Oncotarget. 2017 May 23;8(21):34453-34467. doi: 10.18632/oncotarget.16431.

192.

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats.

Rahman M, Yang DK, Kim GB, Lee SJ, Kim SJ.

Biomed Rep. 2017 Apr;6(4):468-474. doi: 10.3892/br.2017.866. Epub 2017 Feb 24.

193.

Nigella sativa, a traditional Tunisian herbal medicine, attenuates bleomycin-induced pulmonary fibrosis in a rat model.

Abidi A, Robbe A, Kourda N, Ben Khamsa S, Legrand A.

Biomed Pharmacother. 2017 Jun;90:626-637. doi: 10.1016/j.biopha.2017.04.009. Epub 2017 Apr 14.

PMID:
28412654
194.

Thymoquinone Attenuates Brain Injury via an Anti-oxidative Pathway in a Status Epilepticus Rat Model.

Shao YY, Li B, Huang YM, Luo Q, Xie YM, Chen YH.

Transl Neurosci. 2017 Mar 25;8:9-14. doi: 10.1515/tnsci-2017-0003. eCollection 2017 Jan.

195.

Effects of Nigella sativa Extract on Markers of Cerebral Angiogenesis after Global Ischemia of Brain in Rats.

Soleimannejad K, Rahmani A, Hatefi M, Khataminia M, Hafezi Ahmadi MR, Asadollahi K.

J Stroke Cerebrovasc Dis. 2017 Jul;26(7):1514-1520. doi: 10.1016/j.jstrokecerebrovasdis.2017.02.040. Epub 2017 Apr 7.

PMID:
28396188
196.

Anti-Aging Effect of Nigella Sativa Fixed Oil on D-Galactose-Induced Aging in Mice.

Shahroudi MJ, Mehri S, Hosseinzadeh H.

J Pharmacopuncture. 2017 Mar;20(1):29-35. doi: 10.3831/KPI.2017.20.006.

197.

Response to «Commentary on ‘Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study'».

Pipalia PR, Annigeri RG, Mehta R, Jain N.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Jun;123(6):737-738. doi: 10.1016/j.oooo.2017.02.018. Epub 2017 Mar 18. No abstract available.

PMID:
28392231
198.

Finding Novel Antibiotic Substances from Medicinal Plants — Antimicrobial Properties of Nigella Sativa Directed against Multidrug-resistant Bacteria.

Bakal SN, Bereswill S, Heimesaat MM.

Eur J Microbiol Immunol (Bp). 2017 Mar 16;7(1):92-98. doi: 10.1556/1886.2017.00001. eCollection 2017 Mar.

199.

Novel therapeutic approaches of natural oil from black seeds and its underlying mechanisms against kidney dysfunctions in haloperidol-induced male rats.

Akintunde JK, Abubakar OK.

Drug Metab Pers Ther. 2017 May 24;32(2):97-107. doi: 10.1515/dmpt-2016-0044.

PMID:
28384101
200.

Effect of an orally formulated processed black cumin, from Iranian traditional medicine pharmacopoeia, in relieving symptoms of knee osteoarthritis: A prospective, randomized, double-blind and placebo-controlled clinical trial.

Salimzadeh A, Ghourchian A, Choopani R, Hajimehdipoor H, Kamalinejad M, Abolhasani M.

Int J Rheum Dis. 2017 Jun;20(6):691-701. doi: 10.1111/1756-185X.13066. Epub 2017 Apr 5.

PMID:
28378356

01 to 400 of 1126

 

201.

The value of Nigella sativa in the treatment of experimentally induced rhinosinusitis.

Yoruk O, Tatar A, Keles ON, Cakir A.

Acta Otorhinolaryngol Ital. 2017 Feb;37(1):32-37. doi: 10.14639/0392-100X-1143.

202.

Effects of Nigella sativa seeds and certain species of fungi extracts on number and activation of dural mast cells in rats.

Kilinc E, Dagistan Y, Kotan B, Cetinkaya A.

Physiol Int. 2017 Mar 1;104(1):15-24. doi: 10.1556/2060.104.2017.1.8.

PMID:
28361577
203.

Effect of Nigella sativa seed administration on prevention of febrile neutropenia during chemotherapy among children with brain tumors.

Mousa HFM, Abd-El-Fatah NK, Darwish OA, Shehata SF, Fadel SH.

Childs Nerv Syst. 2017 May;33(5):793-800. doi: 10.1007/s00381-017-3372-7. Epub 2017 Mar 27.

PMID:
28349493
204.

Effect of Topical Application of Nigella Sativa Oil and Oral Acetaminophen on Pain in Elderly with Knee Osteoarthritis: A Crossover Clinical Trial.

Kooshki A, Forouzan R, Rakhshani MH, Mohammadi M.

Electron Physician. 2016 Nov 25;8(11):3193-3197. doi: 10.19082/3193. eCollection 2016 Nov.

205.

The impact of formulation attributes and process parameters on black seed oil loaded liposomes and their performance in animal models of analgesia.

Rushmi ZT, Akter N, Mow RJ, Afroz M, Kazi M, de Matas M, Rahman M, Shariare MH.

Saudi Pharm J. 2017 Mar;25(3):404-412. doi: 10.1016/j.jsps.2016.09.011. Epub 2016 Oct 1.

206.

Protective effect of Nigella sativa seeds against spermatocyte chromosomal aberrations and genotoxicity induced by carbon tetrachloride in mice.

Abdel-Moneim AM, Essawy AE, Hamed SS, Abou-Gabal AA, Alzergy AA.

Environ Sci Pollut Res Int. 2017 Apr;24(12):11677-11682. doi: 10.1007/s11356-017-8806-y. Epub 2017 Mar 21.

PMID:
28324259
207.

Polysaccharide of Black cumin (Nigella sativa) modulates molecular signaling cascade of gastric ulcer pathogenesis.

Manjegowda SB, Rajagopal HM, Dharmesh SM.

Int J Biol Macromol. 2017 Aug;101:823-836. doi: 10.1016/j.ijbiomac.2017.03.093. Epub 2017 Mar 18.

PMID:
28322956
208.

Methanol extract of Nigella sativa seed induces changes in the levels of neurotransmitter amino acids in male rat brain regions.

El-Naggar T, Carretero ME, Arce C, Gómez-Serranillos MP.

Pharm Biol. 2017 Dec;55(1):1415-1422. doi: 10.1080/13880209.2017.1302485.

PMID:
28320235
209.

Olfactory Loss Management in View of Avicenna: Focus on Neuroprotective Plants.

Sinaei F, Emami SA, Sahebkar A, Javadi B.

Curr Pharm Des. 2017;23(22):3315-3321. doi: 10.2174/1381612823666170316122949. Review.

PMID:
28302020
210.

The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats.

El Rabey HA, Al-Seeni MN, Bakhashwain AS.

Evid Based Complement Alternat Med. 2017;2017:5439645. doi: 10.1155/2017/5439645. Epub 2017 Feb 16.

211.

Therapeutic Potential of Nigella sativa Oil Against Cyclophosphamide-Induced DNA Damage and Hepatotoxicity.

Tuorkey MJ.

Nutr Cancer. 2017 Apr;69(3):498-504. doi: 10.1080/01635581.2017.1285408. Epub 2017 Feb 17.

PMID:
28287318
212.

Hepatoprotective efficacy of Nigella sativa seeds dietary supplementation against lead acetate-induced oxidative damage in rabbit — Purification and characterization of glutathione peroxidase.

El-Far AH, Korshom MA, Mandour AA, El-Bessoumy AA, El-Sayed YS.

Biomed Pharmacother. 2017 May;89:711-718. doi: 10.1016/j.biopha.2017.02.044. Epub 2017 Mar 24.

PMID:
28273633
213.

Protective Effect of Thymoquinone Against Morphine Injuries to Kidneys of Mice.

Jalili C, Salahshoor MR, Hoseini M, Roshankhah S, Sohrabi M, Shabanizadeh A.

Iran J Kidney Dis. 2017 Mar;11(2):142-150.

214.

Pharmacological basis for the medicinal use of polyherbal formulation and its ingredients in cardiovascular disorders using rodents.

Malik A, Mehmood MH, Channa H, Akhtar MS, Gilani AH.

BMC Complement Altern Med. 2017 Mar 7;17(1):142. doi: 10.1186/s12906-017-1644-0.

215.

Thymoquinone inhibits the migration of mouse neuroblastoma (Neuro-2a) cells by down-regulating MMP-2 and MMP-9.

Arumugam P, Subramanian R, Priyadharsini JV, Gopalswamy J.

Chin J Nat Med. 2016 Dec;14(12):904-912. doi: 10.1016/S1875-5364(17)30015-8.

PMID:
28262117
216.

Stability Study of Algerian Nigella sativa Seeds Stored under Different Conditions.

Ahamad Bustamam MS, Hadithon KA, Mediani A, Abas F, Rukayadi Y, Lajis N, Shaari K, Safinar Ismail I.

J Anal Methods Chem. 2017;2017:7891434. doi: 10.1155/2017/7891434. Epub 2017 Feb 1.

217.

The effect of Nigella sativa on inflammation-induced myocardial fibrosis in male rats.

Norouzi F, Abareshi A, Asgharzadeh F, Beheshti F, Hosseini M, Farzadnia M, Khazaei M.

Res Pharm Sci. 2017 Feb;12(1):74-81. doi: 10.4103/1735-5362.199050.

218.

The Influence of Pluronic F68 and F127 Nanocarrier on Physicochemical Properties, In vitroRelease, and Antiproliferative Activity of Thymoquinone Drug.

Shaarani S, Hamid SS, Mohd Kaus NH.

Pharmacognosy Res. 2017 Jan-Mar;9(1):12-20. doi: 10.4103/0974-8490.199774.

219.

Phytochemistry, pharmacology, and therapeutic uses of black seed (Nigella sativa).

Kooti W, Hasanzadeh-Noohi Z, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D.

Chin J Nat Med. 2016 Oct;14(10):732-745. doi: 10.1016/S1875-5364(16)30088-7. Epub 2016 Oct 31. Review.

PMID:
28236403
220.

Thymoquinone: An IRAK1 inhibitor with in vivo and in vitro anti-inflammatory activities.

Hossen MJ, Yang WS, Kim D, Aravinthan A, Kim JH, Cho JY.

Sci Rep. 2017 Feb 20;7:42995. doi: 10.1038/srep42995.

221.

Oral administration of Nigella sativa oil ameliorates the effect of cisplatin on brush border membrane enzymes, carbohydrate metabolism and antioxidant system in rat intestine.

Shahid F, Farooqui Z, Rizwan S, Abidi S, Parwez I, Khan F.

Exp Toxicol Pathol. 2017 Jun 14;69(5):299-306. doi: 10.1016/j.etp.2017.02.001. Epub 2017 Feb 15.

PMID:
28215571
222.

Safety and efficacy of a polyherbal formulation for the management of dyslipidemia and hyperglycemia in patients with advanced-stage of type-2 diabetes.

Zarvandi M, Rakhshandeh H, Abazari M, Shafiee-Nick R, Ghorbani A.

Biomed Pharmacother. 2017 May;89:69-75. doi: 10.1016/j.biopha.2017.02.016. Epub 2017 Feb 17.

PMID:
28214690
223.
224.

Combination of Nigella sativa and Honey in Eradication of Gastric Helicobacter pylori Infection.

Hashem-Dabaghian F, Agah S, Taghavi-Shirazi M, Ghobadi A.

Iran Red Crescent Med J. 2016 Jun 21;18(11):e23771. doi: 10.5812/ircmj.23771. eCollection 2016 Nov.

225.

Gastroprotective effects of montelukast and Nigella sativa oil against corticosteroid-induced gastric damage: they are much more than antiasthmatic drugs.

Rizk FH, Ibrahim MAA, Abd-Elsalam MM, Soliman NA, Abd-Elsalam SM.

Can J Physiol Pharmacol. 2017 Jun;95(6):714-720. doi: 10.1139/cjpp-2016-0374. Epub 2017 Feb 10.

PMID:
28187265
226.

Erratum: Biogenic synthesis of Zinc oxide nanostructures from Nigella sativa seed: Prospective role as food packaging material inhibiting broad-spectrum quorum sensing and biofilm.

Al-Shabib NA, Husain FM, Ahmed F, Khan RA, Ahmad I, Alsharaeh E, Khan MS, Hussain A, Rehman MT, Yusuf M, Hassan I, Khan JM, Ashraf GM, Alsalme A, Al-Ajmi MF, Tarasov VV, Aliev G.

Sci Rep. 2017 Feb 9;7:42266. doi: 10.1038/srep42266. No abstract available.

227.

An active principle of Nigella sativa L., thymoquinone, showing significant antimicrobial activity against anaerobic bacteria.

Randhawa MA, Alenazy AK, Alrowaili MG, Basha J.

J Intercult Ethnopharmacol. 2016 Nov 21;6(1):97-101. doi: 10.5455/jice.20161018021238. eCollection 2017 Jan-Mar.

228.

Effect of Nigella sativa (black seeds) against methotrexate-induced nephrotoxicity in mice.

Ahmed JH, Abdulmajeed IM.

J Intercult Ethnopharmacol. 2016 Dec 22;6(1):9-13. doi: 10.5455/jice.20161208013809. eCollection 2017 Jan-Mar.

229.

Updates in diagnosis and management of Ebola hemorrhagic fever.

El Sayed SM, Abdelrahman AA, Ozbak HA, Hemeg HA, Kheyami AM, Rezk N, El-Ghoul MB, Nabo MM, Fathy YM.

J Res Med Sci. 2016 Oct 18;21:84. doi: 10.4103/1735-1995.192500. eCollection 2016. Review.

230.

Anthelmintic Potential of Thymoquinone and Curcumin on Fasciola gigantica.

Ullah R, Rehman A, Zafeer MF, Rehman L, Khan YA, Khan MA, Khan SN, Khan AU, Abidi SM.

PLoS One. 2017 Feb 2;12(2):e0171267. doi: 10.1371/journal.pone.0171267. eCollection 2017.

231.

Effect of Nigella sativa supplementation on lung function and inflammatory mediatorsin partly controlled asthma: a randomized controlled trial.

Salem AM, Bamosa AO, Qutub HO, Gupta RK, Badar A, Elnour A, Afzal MN.

Ann Saudi Med. 2017 Jan-Feb;37(1):64-71. doi: 10.5144/0256-4947.2017.64.

232.

Effect of Nigella sativa supplementation over a one-year period on lipid levels, blood pressure and heart rate in type-2 diabetic patients receiving oral hypoglycemic agents: nonrandomized clinical trial.

Badar A, Kaatabi H, Bamosa A, Al-Elq A, Abou-Hozaifa B, Lebda F, Alkhadra A, Al-Almaie S.

Ann Saudi Med. 2017 Jan-Feb;37(1):56-63. doi: 10.5144/0256-4947.2017.56.

233.

Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa.

Majdalawieh AF, Fayyad MW, Nasrallah GK.

Crit Rev Food Sci Nutr. 2017 Dec 12;57(18):3911-3928. doi: 10.1080/10408398.2016.1277971. Review.

PMID:
28140613
234.

Effect of black cumin seeds on growth performance, nutrient utilization, immunity, gut health and nitrogen excretion in broiler chickens.

Kumar P, Patra AK, Mandal GP, Samanta I, Pradhan S.

J Sci Food Agric. 2017 Aug;97(11):3742-3751. doi: 10.1002/jsfa.8237. Epub 2017 Mar 6.

PMID:
28120474
235.

Protective role of Nigella sativa in diabetic nephropathy: A randomized clinical trial.

Ansari ZM, Nasiruddin M, Khan RA, Haque SF.

Saudi J Kidney Dis Transpl. 2017 Jan-Feb;28(1):9-14. doi: 10.4103/1319-2442.198093.

236.

Nigella sativa Supplementation Improves Asthma Control and Biomarkers: A Randomized, Double-Blind, Placebo-Controlled Trial.

Koshak A, Wei L, Koshak E, Wali S, Alamoudi O, Demerdash A, Qutub M, Pushparaj PN, Heinrich M.

Phytother Res. 2017 Mar;31(3):403-409. doi: 10.1002/ptr.5761. Epub 2017 Jan 17.

PMID:
28093815
237.

The effect of thymoquinone on the renal functions following ischemia-reperfusion injury in the rat.

Hammad FT, Lubbad L.

Int J Physiol Pathophysiol Pharmacol. 2016 Dec 25;8(4):152-159. eCollection 2016.

238.

Biochemical characterization, anti-inflammatory properties and ulcerogenic traits of some cold-pressed oils in experimental animals.

Ibrahim FM, Attia HN, Maklad YA, Ahmed KA, Ramadan MF.

Pharm Biol. 2017 Dec;55(1):740-748. doi: 10.1080/13880209.2016.1275705.

PMID:
28056572
239.

Black Seed (Nigella Sativa) and its Constituent Thymoquinone as an Antidote or a Protective Agent Against Natural or Chemical Toxicities.

Tavakkoli A, Ahmadi A, Razavi BM, Hosseinzadeh H.

Iran J Pharm Res. 2017 Winter;16(Suppl):2-23. Review.

240.

Prophylactic effect of Nigella sativa against lead acetate induced changes in spermiogram, reproductive hormones and gonadal histology of rats.

Assi MA, Hezmee MN, Abba Y, Yusof MS, Haron AW, Rajion MA, Al-Zuhairy MA.

Vet World. 2016 Nov;9(11):1305-1311. Epub 2016 Nov 27.

241.

Protective effect of Nigella sativa oil on cisplatin induced nephrotoxicity and oxidative damage in rat kidney.

Farooqui Z, Ahmed F, Rizwan S, Shahid F, Khan AA, Khan F.

Biomed Pharmacother. 2017 Jan;85:7-15. doi: 10.1016/j.biopha.2016.11.110. Epub 2016 Dec 5.

PMID:
27930989
242.

Biogenic synthesis of Zinc oxide nanostructures from Nigella sativa seed: Prospective role as food packaging material inhibiting broad-spectrum quorum sensing and biofilm.

Al-Shabib NA, Husain FM, Ahmed F, Khan RA, Ahmad I, Alsharaeh E, Khan MS, Hussain A, Rehman MT, Yusuf M, Hassan I, Khan JM, Ashraf GM, Alsalme AM, Al-Ajmi MF, Tarasov VV, Aliev G.

Sci Rep. 2016 Dec 5;6:36761. doi: 10.1038/srep36761.

243.

Protective effects of thymoquinone and avenanthramides on titanium dioxide nanoparticles induced toxicity in Sprague-Dawley rats.

Hassanein KM, El-Amir YO.

Pathol Res Pract. 2017 Jan;213(1):13-22. doi: 10.1016/j.prp.2016.08.002. Epub 2016 Aug 9.

PMID:
27916297
244.
245.

Cannabis-induced Moto-Cognitive Dysfunction in Wistar Rats: Ameliorative Efficacy of Nigella Sativa.

Imam A, Ajao MS, Amin A, Abdulmajeed WI, Ibrahim A, Olajide OJ, Ajibola MI, Alli-Oluwafuyi A, Balogun WG.

Malays J Med Sci. 2016 Sep;23(5):17-28. Epub 2016 Oct 5.

246.

Acute and subacute toxicity profiles of thymoquinone-loaded nanostructured lipid carrier in BALB/c mice.

Ong YS, Saiful Yazan L, Ng WK, Noordin MM, Sapuan S, Foo JB, Tor YS.

Int J Nanomedicine. 2016 Nov 9;11:5905-5915. eCollection 2016.

247.

Neurochemical and behavioral effects of Nigella sativa and Olea europaea oil in rats.

Cheema MAR, Nawaz S, Gul S, Salman T, Naqvi S, Dar A, Haleem DJ.

Nutr Neurosci. 2018 Apr;21(3):185-194. doi: 10.1080/1028415X.2016.1257417. Epub 2016 Nov 21.

PMID:
27868798
249.

Effects of Nigella sativa on apoptosis and GABAA receptor density in cerebral cortical and hippocampal neurons in pentylenetetrazol induced kindling in rats.

Meral I, Esrefoglu M, Dar KA, Ustunova S, Aydin MS, Demirtas M, Arifoglu Y.

Biotech Histochem. 2016 Nov;91(8):493-500.

PMID:
27849392
250.

Medicinal Herbs in Iranian Traditional Medicine for Learning and Memory.

Shojaii A, Ghods R, Fard MA.

Iran J Med Sci. 2016 May;41(3 Suppl):S43.

251.

Physicochemical characterization of black seed oil-milk emulsions through ultrasonication.

Anandan S, Keerthiga M, Vijaya S, Asiri AM, Bogush V, Krasulyaa O.

Ultrason Sonochem. 2017 Sep;38:766-771. doi: 10.1016/j.ultsonch.2016.11.005. Epub 2016 Nov 4.

PMID:
27838219
252.

The hepatoprotective activity of olive oil and Nigella sativa oil against CCl4 induced hepatotoxicity in male rats.

Al-Seeni MN, El Rabey HA, Zamzami MA, Alnefayee AM.

BMC Complement Altern Med. 2016 Nov 4;16(1):438.

253.

Retraction note: Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: an experimental study with histopathological evaluation.

Alimohammadi S, Hobbenaghi R, Javanbakht J, Kheradmand D, Mortezaee R, Tavakoli M, Khadivar F, Akbari H.

Diagn Pathol. 2016 Nov 2;11(1):125. No abstract available.

254.

Profile of Trace Elements in Selected Medicinal Plants Used for the Treatment of Diabetes in Eritrea.

Sium M, Kareru P, Keriko J, Girmay B, Medhanie G, Debretsion S.

ScientificWorldJournal. 2016;2016:2752836. Epub 2016 Oct 4.

255.

Upregulation of SIRT1-AMPK by thymoquinone in hepatic stellate cells ameliorates liver injury.

Yang Y, Bai T, Yao YL, Zhang DQ, Wu YL, Lian LH, Nan JX.

Toxicol Lett. 2016 Nov 16;262:80-91. doi: 10.1016/j.toxlet.2016.09.014. Epub 2016 Sep 26.

PMID:
27688165
256.

Thymoquinone: An edible redox-active quinone for the pharmacotherapy of neurodegenerative conditions and glial brain tumors. A short review.

Elmaci I, Altinoz MA.

Biomed Pharmacother. 2016 Oct;83:635-640. doi: 10.1016/j.biopha.2016.07.018. Epub 2016 Jul 25. Review.

PMID:
27459120
257.

Assessment of In vitro Antibacterial Activity and Cytotoxicity Effect of Nigella sativa Oil.

Ugur AR, Dagi HT, Ozturk B, Tekin G, Findik D.

Pharmacogn Mag. 2016 Jul;12(Suppl 4):S471-S474.

259.

Nigella sativa Oil Reduces Extrapyramidal Symptoms (EPS)-Like Behavior in Haloperidol-Treated Rats.

Malik T, Hasan S, Pervez S, Fatima T, Haleem DJ.

Neurochem Res. 2016 Dec;41(12):3386-3398. Epub 2016 Oct 18.

PMID:
27752803
260.

Protective Effects of Thymoquinone Against Convulsant Activity Induced by Lithium-Pilocarpine in a model of Status Epilepticus.

Shao Y, Feng Y, Xie Y, Luo Q, Chen L, Li B, Chen Y.

Neurochem Res. 2016 Dec;41(12):3399-3406. Epub 2016 Oct 18.

PMID:
27752802
261.

Clinicobiochemical evaluation of turmeric with black pepper and nigella sativa in management of oral submucous fibrosis-a double-blind, randomized preliminary study.

Pipalia PR, Annigeri RG, Mehta R.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Dec;122(6):705-712. doi: 10.1016/j.oooo.2016.07.023. Epub 2016 Aug 6.

PMID:
27720650
262.

Mitigation of cadmium-induced lung injury by Nigella sativa oil.

El-Ebiary AA, El-Ghaiesh S, Hantash E, Alomar S.

Environ Sci Pollut Res Int. 2016 Dec;23(24):25356-25363. doi: 10.1007/s11356-016-7603-3. Epub 2016 Oct 1.

PMID:
27696167
263.

Identification of medicinal plants for the treatment of kidney and urinary stones.

Bahmani M, Baharvand-Ahmadi B, Tajeddini P, Rafieian-Kopaei M, Naghdi N.

J Renal Inj Prev. 2016 Jul 27;5(3):129-33. doi: 10.15171/jrip.2016.27. eCollection 2016.

264.

Bullous drug eruption to Nigella sativa oil: Consideration of the use of a herbal medicine — clinical report and review of the literature.

Bonhomme A, Poreaux C, Jouen F, Schmutz JL, Gillet P, Barbaud A.

J Eur Acad Dermatol Venereol. 2017 Apr;31(4):e217-e219. doi: 10.1111/jdv.13982. Epub 2016 Nov 20. No abstract available.

PMID:
27684404
265.

An evidence-based approach to medicinal plants for the treatment of sperm abnormalities in traditional Persian medicine.

Tahvilzadeh M, Hajimahmoodi M, Toliyat T, Karimi M, Rahimi R.

Andrologia. 2016 Oct;48(8):860-79. doi: 10.1111/and.12676. Review.

PMID:
27681644
266.

Nigella sativa oil with a calorie-restricted diet can improve biomarkers of systemic inflammation in obese women: A randomized double-blind, placebo-controlled clinical trial.

Mahdavi R, Namazi N, Alizadeh M, Farajnia S.

J Clin Lipidol. 2016 Sep-Oct;10(5):1203-11. doi: 10.1016/j.jacl.2015.11.019. Epub 2015 Dec 7.

PMID:
27678438
267.

Alternative products to treat allergic rhinitis and alternative routes for allergy immunotherapy.

Ipci K, Oktemer T, Muluk NB, Şahin E, Altıntoprak N, Bafaqeeh SA, Kurt Y, Mladina R, Šubarić M, Cingi C.

Am J Rhinol Allergy. 2016 Sep 1;30(5):8-10. doi: 10.2500/ajra.2016.30.4364. Review.

PMID:
27658026
268.

Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive.

Majdalawieh AF, Fayyad MW.

J Ayurveda Integr Med. 2016 Jul — Sep;7(3):173-180. doi: 10.1016/j.jaim.2016.07.004. Epub 2016 Sep 17. Review.

269.

The Effects of Different Extraction Methods on Antioxidant Properties, Chemical Composition, and Thermal Behavior of Black Seed (Nigella sativa L.) Oil.

Mohammed NK, Abd Manap MY, Tan CP, Muhialdin BJ, Alhelli AM, Meor Hussin AS.

Evid Based Complement Alternat Med. 2016;2016:6273817. doi: 10.1155/2016/6273817. Epub 2016 Aug 25.

270.

Schistosoma mansoni: Antiparasitic effects of orally administered Nigella sativa oil and/or Chroococcus turgidus extract.

Ali M, Eldahab MA, Mansour HA, Nigm A.

Acta Biol Hung. 2016 Sep;67(3):247-60. doi: 10.1556/018.67.2016.3.3.

PMID:
27630048
271.

Effect of Nigella sativa alcoholic extract and oil, as well as Phaseolus vulgaris (kidney bean) lectin on the ultrastructure of Trichomonas vaginalis trophozoites.

Aminou HA, Alam-Eldin YH, Hashem HA.

J Parasit Dis. 2016 Sep;40(3):707-13. doi: 10.1007/s12639-014-0564-x. Epub 2014 Sep 11.

272.

Cardiovascular effect of Nigella sativa L. Aqueous Extract in Normal Rats.

Hebi M, Zeggwagh N, Hajj L, Bouhali BE, Eddouks M.

Cardiovasc Hematol Disord Drug Targets. 2016;16(1):47-55.

PMID:
27605118
273.

The Antioxidant Effects of Thymoquinone in Activated BV-2 Murine Microglial Cells.

Cobourne-Duval MK, Taka E, Mendonca P, Bauer D, Soliman KF.

Neurochem Res. 2016 Dec;41(12):3227-3238. Epub 2016 Sep 1.

274.

Nigella sativa Relieves the Altered Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats Fed with a High-Fat Diet.

Balbaa M, El-Zeftawy M, Ghareeb D, Taha N, Mandour AW.

Oxid Med Cell Longev. 2016;2016:2492107. doi: 10.1155/2016/2492107. Epub 2016 Aug 4.

275.

Nigella sativa (black cumin seed) as a biological detoxifier in diet contaminated with aflatoxin B1.

Rasouli-Hiq AA, Bagherzadeh-Kasmani F, Mehri M, Karimi-Torshizi MA.

J Anim Physiol Anim Nutr (Berl). 2017 Oct;101(5):e77-e86. doi: 10.1111/jpn.12562. Epub 2016 Aug 24.

PMID:
27553624
276.

Thymoquinone Could Increase The Efficacy of Tamoxifen Induced Apoptosis in Human Breast Cancer Cells: An In Vitro Study.

Ganji-Harsini S, Khazaei M, Rashidi Z, Ghanbari A.

Cell J. 2016 Jul-Sep;18(2):245-54. Epub 2016 May 30.

277.

Spices for Prevention and Treatment of Cancers.

Zheng J, Zhou Y, Li Y, Xu DP, Li S, Li HB.

Nutrients. 2016 Aug 12;8(8). pii: E495. doi: 10.3390/nu8080495. Review.

278.

Medicinal Herbs in Iranian Traditional Medicine for Learning and Memory.

Shojaii A, Ghods R, Fard MA.

Iran J Med Sci. 2016 May;41(3):S43.

PMID:
27516676
279.

The Effects of Nigella Sativa Seed Extract on Bone Healing in an Experimental Model.

Ezirganli S, Kazancioglu HO, Ozdemir H, Inan DS, Tek M.

J Craniofac Surg. 2016 Oct;27(7):1905-1909.

PMID:
27513784
280.

A systematic review and meta-analysis of randomized controlled trials investigating the effects of supplementation with Nigella sativa (black seed) on blood pressure.

Sahebkar A, Soranna D, Liu X, Thomopoulos C, Simental-Mendia LE, Derosa G, Maffioli P, Parati G.

J Hypertens. 2016 Nov;34(11):2127-35. doi: 10.1097/HJH.0000000000001049. Review.

PMID:
27512971
281.

The effect of Nigella sativa oil on prevention of myringosclerosis in a Guinea pig model.

Kokten N, Egilmez OK, Dogan Ekici AI, Kalcioglu MT, Tekin M, Yesilada E.

Int J Pediatr Otorhinolaryngol. 2016 Sep;88:52-7. doi: 10.1016/j.ijporl.2016.06.050. Epub 2016 Jun 30.

PMID:
27497387
282.

Protective Effect of Thymoquinone against Cyclophosphamide-Induced Hemorrhagic Cystitis through Inhibiting DNA Damage and Upregulation of Nrf2 Expression.

Gore PR, Prajapati CP, Mahajan UB, Goyal SN, Belemkar S, Ojha S, Patil CR.

Int J Biol Sci. 2016 Jun 7;12(8):944-53. doi: 10.7150/ijbs.15781. eCollection 2016.

283.

Thymoquinone subdues tumor growth and potentiates the chemopreventive effect of 5-fluorouracil on the early stages of colorectal carcinogenesis in rats.

Kensara OA, El-Shemi AG, Mohamed AM, Refaat B, Idris S, Ahmad J.

Drug Des Devel Ther. 2016 Jul 11;10:2239-53. doi: 10.2147/DDDT.S109721. eCollection 2016.

284.

Tribological behavior of UHMWPE against TiAl6V4 and CoCr28Mo alloys under dry and lubricated conditions.

Guezmil M, Bensalah W, Mezlini S.

J Mech Behav Biomed Mater. 2016 Oct;63:375-385. doi: 10.1016/j.jmbbm.2016.07.002. Epub 2016 Jul 7.

PMID:
27454523
285.

The effects of Nigella sativa on neural damage after pentylenetetrazole induced seizures in rats.

Seghatoleslam M, Alipour F, Shafieian R, Hassanzadeh Z, Edalatmanesh MA, Sadeghnia HR, Hosseini M.

J Tradit Complement Med. 2015 Aug 11;6(3):262-8. doi: 10.1016/j.jtcme.2015.06.003. eCollection 2016 Jul.

286.

Antimicrobial and anti-Quorum Sensing activities of selected medicinal plants of Ethiopia: Implication for development of potent antimicrobial agents.

Bacha K, Tariku Y, Gebreyesus F, Zerihun S, Mohammed A, Weiland-Bräuer N, Schmitz RA, Mulat M.

BMC Microbiol. 2016 Jul 11;16(1):139. doi: 10.1186/s12866-016-0765-9.

287.

Use of complementary and alternative medicines in haemodialysis patients: a cross-sectional study from Palestine.

Zyoud SH, Al-Jabi SW, Sweileh WM, Tabeeb GH, Ayaseh NA, Sawafta MN, Khdeir RL, Mezyed DO, Daraghmeh DN, Awang R.

BMC Complement Altern Med. 2016 Jul 11;16:204. doi: 10.1186/s12906-016-1196-8.

288.

Repellency to ticks (Acari: Ixodidae) of extracts of Nigella sativa (Ranunculaceae) and the anti-inflammatory DogsBestFriend™.

Carroll JF, Babish JG, Pacioretty LM, Kramer M.

Exp Appl Acarol. 2016 Sep;70(1):89-97. doi: 10.1007/s10493-016-0058-x. Epub 2016 Jul 9.

PMID:
27394440
289.

Nigella sativa oil and thymoquinone ameliorate albuminuria and renal extracellular matrix accumulation in the experimental diabetic rats.

Al-Trad B, Al-Batayneh K, El-Metwally S, Alhazimi A, Ginawi I, Alaraj M, Alkofahi E, Aljumaili O, Kosba A.

Eur Rev Med Pharmacol Sci. 2016 Jun;20(12):2680-8.

290.

Thymoquinone effectively alleviates lung fibrosis induced by paraquat herbicide through down-regulation of pro-fibrotic genes and inhibition of oxidative stress.

Pourgholamhossein F, Sharififar F, Rasooli R, Pourgholi L, Nakhaeipour F, Samareh-Fekri H, Iranpour M, Mandegary A.

Environ Toxicol Pharmacol. 2016 Jul;45:340-5. doi: 10.1016/j.etap.2016.06.019. Epub 2016 Jun 18.

PMID:
27375216
291.

Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review.

Gholamnezhad Z, Havakhah S, Boskabady MH.

J Ethnopharmacol. 2016 Aug 22;190:372-86. doi: 10.1016/j.jep.2016.06.061. Epub 2016 Jun 27. Review.

PMID:
27364039
292.

IN VIVO AND IN VITRO EFFICACY OF NIGELLA SATIVA AQUEOUS EXTRACT ON BLASTOCYSTIS HOMINIS.

Eida OM, El-Shafei HA, Nomeir YA, El Safhi MB.

J Egypt Soc Parasitol. 2016 Apr;46(1):27-34.

PMID:
27363038
293.

Effect of Nigella sativa L. seed extract on cisplatin-induced delay in gastric emptying in Sprague-Dawley rats.

Riyaz A, Nazir S, Khushtar M, Mishra A, Jahan Y, Ahmad A.

Nat Prod Res. 2017 Mar;31(5):588-592. doi: 10.1080/14786419.2016.1201670. Epub 2016 Jun 27.

PMID:
27348571
294.

Rhipicephalus annulatus (Acari: Ixodidae) Control by Nigella sativa, Thyme and Spinosad Preparations.

Aboelhadid SM, Mahran HA, El-Hariri HM, Shokier KM.

J Arthropod Borne Dis. 2016 Jan 5;10(2):148-58. eCollection 2016 Jun.

295.

Panacea seed «Nigella«: A review focusing on regenerative effects for gastric ailments.

Khan SA, Khan AM, Karim S, Kamal MA, Damanhouri GA, Mirza Z.

Saudi J Biol Sci. 2016 Jul;23(4):542-53. doi: 10.1016/j.sjbs.2014.10.001. Epub 2014 Oct 13.

296.

Minimization of the Risk of Diabetic Microangiopathy in Rats by Nigella sativa.

Somboonwong J, Yusuksawad M, Keelawat S, Thongruay S, Poumsuk U.

Pharmacogn Mag. 2016 May;12(Suppl 2):S175-80. doi: 10.4103/0973-1296.182169. Epub 2016 May 11.

297.

Therapeutic Efficacy of Nigella Sativa Linn. against Antituberculosis Drug-Induced Hepatic Injury in Wistar Rats.

Jaswal A, Sharma M, Raghuvanshi S, Sharma S, Reshi MS, Uthra C, Shukla S.

J Environ Pathol Toxicol Oncol. 2016;35(1):59-71. doi: 10.1615/JEnvironPatholToxicolOncol.2016013789.

PMID:
27279584
298.

Thymoquinone, an active constituent of Nigella sativa seeds, binds with bilirubin and protects mice from hyperbilirubinemia and cyclophosphamide-induced hepatotoxicity.

Laskar AA, Khan MA, Rahmani AH, Fatima S, Younus H.

Biochimie. 2016 Aug;127:205-13. doi: 10.1016/j.biochi.2016.05.020. Epub 2016 Jun 2.

PMID:
27265787
299.

Thymoquinone induces apoptosis and increase ROS in ovarian cancer cell line.

Taha MM, Sheikh BY, Salim LZ, Mohan S, Khan A, Kamalidehghan B, Ahmadipour F, Abdelwahab SI.

Cell Mol Biol (Noisy-le-grand). 2016 May 30;62(6):97-101.

PMID:
27262811
300.

Safety evaluation of Phytovagex, a pessary formulation of Nigella sativa, on pregnant rats.

Salarinia R, Rakhshandeh H, Oliaee D, Gul Ghasemi S, Ghorbani A.

Avicenna J Phytomed. 2016 Jan-Feb;6(1):117-23.

301.

Neuropharmacological effects of Nigella sativa.

Beheshti F, Khazaei M, Hosseini M.

Avicenna J Phytomed. 2016 Jan-Feb;6(1):104-16. Review.

302.

The effects of Nigella sativa on sickness behavior induced by lipopolysaccharide in male Wistar rats.

Norouzi F, Abareshi A, Anaeigoudari A, Shafei MN, Gholamnezhad Z, Saeedjalali M, Mohebbati R, Hosseini M.

Avicenna J Phytomed. 2016 Jan-Feb;6(1):104-16.

303.

Effect of Nigella sativa on reproductive system in experimental menopause rat model.

Parhizkar S, Latiff LA, Parsa A.

Avicenna J Phytomed. 2016 Jan-Feb;6(1):95-103.

304.

Adriamycin-induced oxidative stress is prevented by mixed hydro-alcoholic extract of Nigella sativa and Curcuma longa in rat kidney.

Mohebbati R, Shafei MN, Soukhtanloo M, Mohammadian Roshan N, Khajavi Rad A, Anaeigoudari A, Hosseinian S, Karimi S, Beheshti F.

Avicenna J Phytomed. 2016 Jan-Feb;6(1):86-94.

305.

Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbumin-sensitized male rats.

Fallahi M, Keyhanmanesh R, Khamaneh AM, Ebrahimi Saadatlou MA, Saadat S, Ebrahimi H.

Avicenna J Phytomed. 2016 Jan-Feb;6(1):77-85.

306.

Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta.

Abbasnezhad A, Niazmand S, Mahmoudabady M, Soukhtanloo M, Rezaee SA, Mousavi SM.

Avicenna J Phytomed. 2016 Jan-Feb;6(1):67-76.

307.

Attenuation of morphine tolerance and dependence by thymoquinone in mice.

Hosseinzadeh H, Parvardeh S, Masoudi A, Moghimi M, Mahboobifard F.

Avicenna J Phytomed. 2016 Jan-Feb;6(1):55-66.

308.

The protective effect of Nigella sativa against cisplatin-induced nephrotoxicity in rats.

Hosseinian S, Khajavi Rad A, Hadjzadeh MA, Mohamadian Roshan N, Havakhah S, Shafiee S.

Avicenna J Phytomed. 2016 Jan-Feb;6(1):44-54.

310.
311.

Gastrointestinal effects of Nigella sativa and its main constituent, thymoquinone: a review.

Shakeri F, Gholamnezhad Z, Mégarbane B, Rezaee R, Boskabady MH.

Avicenna J Phytomed. 2016 Jan-Feb;6(1):9-20. Review.

312.

Renal injury, nephrolithiasis and Nigella sativa: A mini review.

Hayatdavoudi P, Khajavi Rad A, Rajaei Z, Hadjzadeh MA.

Avicenna J Phytomed. 2016 Jan-Feb;6(1):1-8. Review.

313.

Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice.

Su X, Ren Y, Yu N, Kong L, Kang J.

Int Immunopharmacol. 2016 Sep;38:70-80. doi: 10.1016/j.intimp.2016.05.018. Epub 2016 May 27.

PMID:
27240137
314.

Protective Effect of Nigella Sativa on Renal Reperfusion Injury in Rat.

Caskurlu T, Kanter M, Erboga M, Erboga ZF, Ozgul M, Atis G.

Iran J Kidney Dis. 2016 May;10(3):135-43.

315.

A review of Neuropharmacology Effects of Nigella sativa and Its Main Component, Thymoquinone.

Javidi S, Razavi BM, Hosseinzadeh H.

Phytother Res. 2016 Aug;30(8):1219-29. doi: 10.1002/ptr.5634. Epub 2016 May 11. Review.

PMID:
27169925
316.

Complementary and alternative therapies and health literacy in cancer patients.

Dişsiz G, Yilmaz M.

Complement Ther Clin Pract. 2016 May;23:34-9. doi: 10.1016/j.ctcp.2016.02.004. Epub 2016 Mar 2.

PMID:
27157956
317.

Effects of Bread with Nigella Sativa on Lipid Profiles, Apolipoproteins and Inflammatory Factor in Metabolic Syndrome Patients.

Mohtashami A, Mahaki B, Azadbakht L, Entezari MH.

Clin Nutr Res. 2016 Apr;5(2):89-95. doi: 10.7762/cnr.2016.5.2.89. Epub 2016 Apr 30.

318.

Effect of Thymoquinone on P53 Gene Expression and Consequence Apoptosis in Breast Cancer Cell Line.

Dastjerdi MN, Mehdiabady EM, Iranpour FG, Bahramian H.

Int J Prev Med. 2016 Apr 14;7:66. doi: 10.4103/2008-7802.180412. eCollection 2016.

319.

Feeding of Nigella sativa during neonatal and juvenile growth improves learning and memory of rats.

Beheshti F, Hosseini M, Vafaee F, Shafei MN, Soukhtanloo M.

J Tradit Complement Med. 2015 Jan 17;6(2):146-52. doi: 10.1016/j.jtcme.2014.11.039. eCollection 2016 Apr.

320.

A nanotechnology based new approach for chemotherapy of Cutaneous Leishmaniasis: TIO2@AG nanoparticles — Nigella sativa oil combinations.

Abamor ES, Allahverdiyev AM.

Exp Parasitol. 2016 Jul;166:150-63. doi: 10.1016/j.exppara.2016.04.008. Epub 2016 Apr 22.

PMID:
27109311
321.

Immunomodulatory Effect of Nigella sativa Oil on T Lymphocytes in Patients with Rheumatoid Arthritis.

Kheirouri S, Hadi V, Alizadeh M.

Immunol Invest. 2016 May;45(4):271-83. doi: 10.3109/08820139.2016.1153649. Epub 2016 Apr 21.

PMID:
27100726
322.

Effects of thymoquinone, the major constituent of Nigella sativa seeds, on penicillin-induced epileptiform activity in rats.

Beyazcicek E, Ankarali S, Beyazcicek O, Ankarali H, Demir S, Ozmerdivenli R.

Neurosciences (Riyadh). 2016 Apr;21(2):131-7. doi: 10.17712/nsj.2016.2.20150781.

323.

Chemical composition of Nigella sativa Linn: Part 2 Recent advances.

Akram Khan M, Afzal M.

Inflammopharmacology. 2016 Jun;24(2-3):67-79. doi: 10.1007/s10787-016-0262-7. Epub 2016 Apr 11. Review.

324.

Are the fatty acids responsible for the higher effect of oil and alcoholic extract of Nigella sativaover its aqueous extract on Trichomonas vaginalis trophozoites?

Mahmoud MA, Aminou HA, Hashem HA.

J Parasit Dis. 2016 Mar;40(1):22-31. doi: 10.1007/s12639-014-0479-6. Epub 2014 Jun 3.

325.

Thymoquinone Inhibits Angiotensin II-Induced Proliferation and Migration of Vascular Smooth Muscle Cells Through the AMPK/PPARγ/PGC-1α Pathway.

Pei X, Li X, Chen H, Han Y, Fan Y.

DNA Cell Biol. 2016 Aug;35(8):426-33. doi: 10.1089/dna.2016.3262. Epub 2016 Apr 11.

PMID:
27064837
326.

Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneys.

Mabrouk A, Ben Cheikh H.

Libyan J Med. 2016 Apr 5;11:31018. doi: 10.3402/ljm.v11.31018. eCollection 2016.

327.

Protective effects of thymoquinone and alpha-tocopherol on the sciatic nerve and femoral muscle due to lower limb ischemia-reperfusion injury.

Erkut A, Cure MC, Kalkan Y, Balik MS, Guvercin Y, Yaprak E, Yuce S, Sehitoglu I, Cure E.

Eur Rev Med Pharmacol Sci. 2016;20(6):1192-202.

328.

Commercial and Plant Extract Denture Cleansers in Prevention of Candida albicans Growth on Soft Denture Reliner: In Vitro Study.

Khan MA, Dhaded S, Joshi S.

J Clin Diagn Res. 2016 Feb;10(2):ZC42-5. doi: 10.7860/JCDR/2016/12558.7228. Epub 2016 Feb 1.

329.

Protective Mechanisms of Thymoquinone on Methotrexate-induced Intestinal Toxicity in Rats.

El-Sheikh AA, Morsy MA, Hamouda AH.

Pharmacogn Mag. 2016 Jan;12(Suppl 1):S76-81. doi: 10.4103/0973-1296.176106.

330.

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J Microsc Ultrastruct. 2016 Apr-Jun;4(2):76-84. doi: 10.1016/j.jmau.2015.12.001. Epub 2015 Dec 15.

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Sahak MK, Kabir N, Abbas G, Draman S, Hashim NH, Hasan Adli DS.

Evid Based Complement Alternat Med. 2016;2016:6075679. doi: 10.1155/2016/6075679. Epub 2016 Feb 28. Review.

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Proteomic Analysis of the Protein Expression Profile in the Mature Nigella sativa (Black Seed).

Alanazi IO, Benabdelkamel H, Alfadda AA, AlYahya SA, Alghamdi WM, Aljohi HA, Almalik A, Masood A.

Appl Biochem Biotechnol. 2016 Aug;179(7):1184-201. doi: 10.1007/s12010-016-2058-z. Epub 2016 Mar 28.

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In silico Analysis for Predicting Fatty Acids of Black Cumin Oil as Inhibitors of P-Glycoprotein.

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Pharmacogn Mag. 2015 Oct;11(Suppl 4):S606-10. doi: 10.4103/0973-1296.172969.

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Food Chem. 2016 Aug 1;204:326-33. doi: 10.1016/j.foodchem.2016.02.143. Epub 2016 Feb 26.

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Protective Effects of Thymoquinone against Methotrexate-Induced Germ Cell Apoptosis in Male Mice.

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Int J Fertil Steril. 2016 Jan-Mar;9(4):541-7. Epub 2015 Dec 23.

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J Microencapsul. 2016;33(2):114-26. doi: 10.3109/02652048.2015.1134689. Epub 2016 Mar 16.

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Asian Pac J Trop Med. 2016 Mar;9(3):221-7. doi: 10.1016/j.apjtm.2016.01.039. Epub 2016 Jan 13.

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Protective effect of thymoquinone against lead-induced hepatic toxicity in rats.

Mabrouk A, Bel Hadj Salah I, Chaieb W, Ben Cheikh H.

Environ Sci Pollut Res Int. 2016 Jun;23(12):12206-15. doi: 10.1007/s11356-016-6419-5. Epub 2016 Mar 14.

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Anticancer activity of an ultrasonic nanoemulsion formulation of Nigella sativa L. essential oil on human breast cancer cells.

Periasamy VS, Athinarayanan J, Alshatwi AA.

Ultrason Sonochem. 2016 Jul;31:449-55. doi: 10.1016/j.ultsonch.2016.01.035. Epub 2016 Jan 29.

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Paracetamol-induced nephrotoxicity and oxidative stress in rats: the protective role of Nigella sativa.

Canayakin D, Bayir Y, Kilic Baygutalp N, Sezen Karaoglan E, Atmaca HT, Kocak Ozgeris FB, Keles MS, Halici Z.

Pharm Biol. 2016 Oct;54(10):2082-91. doi: 10.3109/13880209.2016.1145701. Epub 2016 Mar 9.

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Male infertility: lifestyle factors and holistic, complementary, and alternative therapies.

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Asian J Androl. 2016 May-Jun;18(3):410-8. doi: 10.4103/1008-682X.175779. Review.

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Essential oils of Nigella sativa protects Artemia from the pathogenic effect of Vibrio parahaemolyticus Dahv2.

Manju S, Malaikozhundan B, Withyachumnarnkul B, Vaseeharan B.

J Invertebr Pathol. 2016 May;136:43-9. doi: 10.1016/j.jip.2016.03.004. Epub 2016 Mar 2.

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Protective effects of Nigella sativa on gamma radiation-induced jejunal mucosal damage in rats.

Orhon ZN, Uzal C, Kanter M, Erboga M, Demiroglu M.

Pathol Res Pract. 2016 May;212(5):437-43. doi: 10.1016/j.prp.2016.02.017. Epub 2016 Feb 17.

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Role of Nigella sativa seed oil on corneal injury induced by formaldehyde in adult male albino rats.

Salem NA, Mahmoud OM, Al Badawi MH, Gab-Alla AA.

Folia Morphol (Warsz). 2016;75(4):518-526. doi: 10.5603/FM.a2016.0010. Epub 2016 Feb 26.

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The use of medicinal herbs in gynecological and pregnancy-related disorders by Jordanian women: a review of folkloric practice vs. evidence-based pharmacology.

Akour A, Kasabri V, Afifi FU, Bulatova N.

Pharm Biol. 2016 Sep;54(9):1901-18. doi: 10.3109/13880209.2015.1113994. Epub 2016 Feb 25. Review.

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Saudi Med J. 2016 Mar;37(3):235-44. doi: 10.15537/smj.2016.3.13006. Review.

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Nigella sativa (black seed) effects on plasma lipid concentrations in humans: A systematic review and meta-analysis of randomized placebo-controlled trials.

Sahebkar A, Beccuti G, Simental-Mendía LE, Nobili V, Bo S.

Pharmacol Res. 2016 Apr;106:37-50. doi: 10.1016/j.phrs.2016.02.008. Epub 2016 Feb 10. Review.

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Neuroprotective effects of thymoquinone against spinal cord ischemia-reperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis.

Gökce EC, Kahveci R, Gökce A, Cemil B, Aksoy N, Sargon MF, Kısa Ü, Erdoğan B, Güvenç Y, Alagöz F, Kahveci O.

J Neurosurg Spine. 2016 Jun;24(6):949-59. doi: 10.3171/2015.10.SPINE15612. Epub 2016 Feb 12.

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Effect of total hydroalcholic extract of Nigella sativa and its n-hexane and ethyl acetate fractions on ACHN and GP-293 cell lines.

Shahraki S, Khajavirad A, Shafei MN, Mahmoudi M, Tabasi NS.

J Tradit Complement Med. 2015 Jan 29;6(1):89-96. doi: 10.1016/j.jtcme.2014.11.018. eCollection 2016 Jan.

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Efficacy of local application of an Unani formulation in acne vulgaris.

Sultana S, Zulkifle M, Ansari AH, Shahnawaz.

Anc Sci Life. 2015 Oct-Dec;35(2):124-8. doi: 10.4103/0257-7941.171668.

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Oral administration of Nigella sativa oil ameliorates the effect of cisplatin on membrane enzymes, carbohydrate metabolism and oxidative damage in rat liver.

Farooqui Z, Afsar M, Rizwan S, Khan AA, Khan F.

Toxicol Rep. 2016 Feb 13;3:328-335. doi: 10.1016/j.toxrep.2016.02.004. eCollection 2016.

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Responses of Nigella sativa L. to Zinc Excess: Focus on Germination, Growth, Yield and Yield Components, Lipid and Terpene Metabolism, and Total Phenolics and Antioxidant Activities.

Marichali A, Dallali S, Ouerghemmi S, Sebei H, Casabianca H, Hosni K.

J Agric Food Chem. 2016 Mar 2;64(8):1664-75. doi: 10.1021/acs.jafc.6b00274. Epub 2016 Feb 17.

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Thymoquinone from Nigella sativa Seeds Promotes the Antitumor Activity of Noncytotoxic Doses of Topotecan in Human Colorectal Cancer Cells in Vitro.

Khalife R, Hodroj MH, Fakhoury R, Rizk S.

Planta Med. 2016 Mar;82(4):312-21. doi: 10.1055/s-0035-1558289. Epub 2016 Feb 5.

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Effect of lipid extracts of Nigella sativa L. seeds on the liver ATP reduction and alpha-glucosidase inhibition.

Sobhi W, Stevigny C, Duez P, Calderon BB, Atmani D, Benboubetra M.

Pak J Pharm Sci. 2016 Jan;29(1):111-7.

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Vasorelaxant effect of essential oil isolated from Nigella sativa L. seeds in rat aorta: Proposed mechanism.

Cherkaoui-Tangi K, Israili ZH, Lyoussi B.

Pak J Pharm Sci. 2016 Jan;29(1):1-8.

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Ethanolic extract of Nigella sativa protects Fe(II) induced lipid peroxidation in rat’s brain, kidney and liver homogenates.

Hassan W, Noreen H, Khalil S, Hussain A, Rehman S, Sajjad S, Rahman A, da Rocha JB.

Pak J Pharm Sci. 2016 Jan;29(1):231-7.

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Modulation of Hydrogen Peroxide-Induced Oxidative Stress in Human Neuronal Cells by Thymoquinone-Rich Fraction and Thymoquinone via Transcriptomic Regulation of Antioxidant and Apoptotic Signaling Genes.

Ismail N, Ismail M, Azmi NH, Abu Bakar MF, Basri H, Abdullah MA.

Oxid Med Cell Longev. 2016;2016:2528935. doi: 10.1155/2016/2528935. Epub 2015 Dec 28.

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Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA.

Gray JP, Burgos DZ, Yuan T, Seeram N, Rebar R, Follmer R, Heart EA.

Am J Physiol Endocrinol Metab. 2016 Mar 15;310(6):E394-404. doi: 10.1152/ajpendo.00250.2015. Epub 2016 Jan 19.

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Thymoquinone strongly inhibits fMLF-induced neutrophil functions and exhibits anti-inflammatory properties in vivo.

Boudiaf K, Hurtado-Nedelec M, Belambri SA, Marie JC, Derradji Y, Benboubetra M, El-Benna J, Dang PM.

Biochem Pharmacol. 2016 Mar 15;104:62-73. doi: 10.1016/j.bcp.2016.01.006. Epub 2016 Jan 13.

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In vitro profiling of antimethicillin-resistant Staphylococcus aureus activity of thymoquinone against selected type and clinical strains.

Hariharan P, Paul-Satyaseela M, Gnanamani A.

Lett Appl Microbiol. 2016 Mar;62(3):283-9. doi: 10.1111/lam.12544.

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Management of Usr-i-Tamth (Menstrual Pain) in Unani (Greco-Islamic) Medicine.

Sultana A, Lamatunoor S, Begum M, Qhuddsia QN.

J Evid Based Complementary Altern Med. 2015 Dec 30. pii: 2156587215623637. [Epub ahead of print]

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COMPARISON OF ANTI-INFLAMMATORY ACTIVITY OF NIGELLA SATIVA AND DICLOFENAC SODIUM IN ALBINO RATS.

Bashir MU, Qureshi HJ, Saleem T.

J Ayub Med Coll Abbottabad. 2015 Jul-Sep;27(3):523-6.

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Investigation of Thionins from Black Cumin (Nigella sativa L.) Seeds Showing Cytotoxic, Regulatory and Antifungal Activity.

Kul’ko AB, Kisl OV, Sadykova VS, Mikhailov VF, Vasilieva IM, Shulenina LV, Zasukhina GD, Rogozhin EA.

Antibiot Khimioter. 2016;61(9-10):8-16. English, Russian.

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Thymoquinone ameliorates lead-induced suppression of the antioxidant system in rat kidneys.

Mabrouk A, Cheikh HB.

Libyan J Med. 2016 Jan;11(1):31018. doi: 10.3402/ljm.v11.31018.

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Antibacterial, antibiofilm and cytotoxic effects of Nigella sativa essential oil coated gold nanoparticles.

Manju S, Malaikozhundan B, Vijayakumar S, Shanthi S, Jaishabanu A, Ekambaram P, Vaseeharan B.

Microb Pathog. 2016 Feb;91:129-35. doi: 10.1016/j.micpath.2015.11.021. Epub 2015 Dec 15.

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Effects of Nigella sativa L. seed oil on intima-media thickness and Bax and Caspase 3 expression in diabetic rat aorta.

Cüce G, Sözen ME, Çetinkaya S, Canbaz HT, Seflek H, Kalkan S.

Anatol J Cardiol. 2015 Jul 14. doi: 10.5152/AnatolJCardiol.2015.6326. [Epub ahead of print]

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The Protective Effects of Nigella sativa and Its Constituents on Induced Neurotoxicity.

Khazdair MR.

J Toxicol. 2015;2015:841823. doi: 10.1155/2015/841823. Epub 2015 Oct 29. Review.

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Mechanisms of the antihypertensive effects of Nigella sativa oil in L-NAME-induced hypertensive rats.

Jaarin K, Foong WD, Yeoh MH, Kamarul ZY, Qodriyah HM, Azman A, Zuhair JS, Juliana AH, Kamisah Y.

Clinics (Sao Paulo). 2015 Nov;70(11):751-7. doi: 10.6061/clinics/2015(11)07.

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Potential risks associated with traditional herbal medicine use in cancer care: A study of Middle Eastern oncology health care professionals.

Ben-Arye E, Samuels N, Goldstein LH, Mutafoglu K, Omran S, Schiff E, Charalambous H, Dweikat T, Ghrayeb I, Bar-Sela G, Turker I, Hassan A, Hassan E, Saad B, Nimri O, Kebudi R, Silbermann M.

Cancer. 2016 Feb 15;122(4):598-610. doi: 10.1002/cncr.29796. Epub 2015 Nov 24.

375.

Effectiveness of Topical Nigella sativa Seed Oil in the Treatment of Cyclic Mastalgia: A Randomized, Triple-Blind, Active, and Placebo-Controlled Clinical Trial.

Huseini HF, Kianbakht S, Mirshamsi MH, Zarch AB.

Planta Med. 2016 Mar;82(4):285-8. doi: 10.1055/s-0035-1558208. Epub 2015 Nov 19.

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Recent Patents of Complementary and Alternative Medicine for Allergic Rhinitis.

Hon KL, Fung CK, Leung AK, Lam HS, Lee SL.

Recent Pat Inflamm Allergy Drug Discov. 2015;9(2):107-19. Review.

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Implication of thymoquinone as a remedy for polycystic ovary in rat.

Arif M, Thakur SC, Datta K.

Pharm Biol. 2016;54(4):674-85. doi: 10.3109/13880209.2015.1072565. Epub 2015 Oct 29.

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The combination of thymoquinone and paclitaxel shows anti-tumor activity through the interplay with apoptosis network in triple-negative breast cancer.

Şakalar Ç, İzgi K, İskender B, Sezen S, Aksu H, Çakır M, Kurt B, Turan A, Canatan H.

Tumour Biol. 2016 Apr;37(4):4467-77. doi: 10.1007/s13277-015-4307-0. Epub 2015 Oct 26.

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Effect of Nigella sativa oil on experimental toxoplasmosis.

Mady RF, El-Hadidy W, Elachy S.

Parasitol Res. 2016 Jan;115(1):379-90. doi: 10.1007/s00436-015-4759-6. Epub 2015 Oct 7.

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The effects of hydroalcoholic extract of Nigella sativa seed on oxidative stress in hippocampus of STZ-induced diabetic rats.

Abbasnezhad A, Hayatdavoudi P, Niazmand S, Mahmoudabady M.

Avicenna J Phytomed. 2015 Jul-Aug;5(4):333-40.

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The subtle central effect of nutraceuticals: Is it placebo or nocebo?

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J Intercult Ethnopharmacol. 2015 Jul-Sep;4(3):221-3. doi: 10.5455/jice.20150403055054. Epub 2015 Apr 7.

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Health-promoting value and food applications of black cumin essential oil: an overview.

Hassanien MF, Assiri AM, Alzohairy AM, Oraby HF.

J Food Sci Technol. 2015 Oct;52(10):6136-42. doi: 10.1007/s13197-015-1785-4. Epub 2015 Mar 27. Review.

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Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial.

Mohtashami R, Huseini HF, Heydari M, Amini M, Sadeqhi Z, Ghaznavi H, Mehrzadi S.

J Ethnopharmacol. 2015 Dec 4;175:147-52. doi: 10.1016/j.jep.2015.09.022. Epub 2015 Sep 18.

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Nigella sativa fixed and essential oil modulates glutathione redox enzymes in potassium bromate induced oxidative stress.

Sultan MT, Butt MS, Karim R, Ahmed W, Kaka U, Ahmad S, Dewanjee S, Jaafar HZ, Zia-Ul-Haq M.

BMC Complement Altern Med. 2015 Sep 18;15:330. doi: 10.1186/s12906-015-0853-7.

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Black Cumin (Nigella sativa) and Its Active Constituent, Thymoquinone: An Overview on the Analgesic and Anti-inflammatory Effects.

Amin B, Hosseinzadeh H.

Planta Med. 2016 Jan;82(1-2):8-16. doi: 10.1055/s-0035-1557838. Epub 2015 Sep 14. Review.

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Study on the effect of black cumin (Nigella sativa Linn.) on experimental renal ischemia-reperfusion injury in rats.

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Acta Cir Bras. 2015 Aug;30(8):542-50. doi: 10.1590/S0102-865020150080000005.

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Evaluation of Antioxidant and Antibacterial Potentials of Nigella sativa L. Suspension Cultures under Elicitation.

Chaudhry H, Fatima N, Ahmad IZ.

Biomed Res Int. 2015;2015:708691. doi: 10.1155/2015/708691. Epub 2015 Aug 12.

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Immunomodulatory and cytotoxic effects of Nigella sativa and thymoquinone on rat splenocytes.

Gholamnezhad Z, Rafatpanah H, Sadeghnia HR, Boskabady MH.

Food Chem Toxicol. 2015 Dec;86:72-80. doi: 10.1016/j.fct.2015.08.028. Epub 2015 Sep 3.

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Enhancement of Bioavailability and Pharmacodynamic Effects of Thymoquinone Via Nanostructured Lipid Carrier (NLC) Formulation.

Elmowafy M, Samy A, Raslan MA, Salama A, Said RA, Abdelaziz AE, El-Eraky W, El Awdan S, Viitala T.

AAPS PharmSciTech. 2016 Jun;17(3):663-72. doi: 10.1208/s12249-015-0391-0. Epub 2015 Aug 25.

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Anti-inflammatory effects of thymoquinone in activated BV-2 microglial cells.

Taka E, Mazzio EA, Goodman CB, Redmon N, Flores-Rozas H, Reams R, Darling-Reed S, Soliman KF.

J Neuroimmunol. 2015 Sep 15;286:5-12. doi: 10.1016/j.jneuroim.2015.06.011. Epub 2015 Jun 27.

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The Protective Effect of α-Hederin, the Active Constituent of Nigella sativa, on Lung Inflammation and Blood Cytokines in Ovalbumin Sensitized Guinea Pigs.

Keyhanmanesh R, Saadat S, Mohammadi M, Shahbazfar AA, Fallahi M.

Phytother Res. 2015 Nov;29(11):1761-7. doi: 10.1002/ptr.5429. Epub 2015 Aug 21.

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Antimicrobial activities of Saudi honey against Pseudomonas aeruginosa.

Al-Nahari AA, Almasaudi SB, Abd El-Ghany el SM, Barbour E, Al Jaouni SK, Harakeh S.

Saudi J Biol Sci. 2015 Sep;22(5):521-5. doi: 10.1016/j.sjbs.2015.04.006. Epub 2015 Apr 8.

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Protective efficacy of Nigella sativa seeds and oil against columnaris disease in fishes.

Mohammed HH, Arias CR.

J Fish Dis. 2016 Jun;39(6):693-703. doi: 10.1111/jfd.12402. Epub 2015 Aug 12.

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Thymoquinone Anticancer Discovery: Possible Mechanisms.

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Curr Drug Discov Technol. 2015;12(2):80-9. Review.

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Nigella sativa amliorates inflammation and demyelination in the experimental autoimmune encephalomyelitis-induced Wistar rats.

Noor NA, Fahmy HM, Mohammed FF, Elsayed AA, Radwan NM.

Int J Clin Exp Pathol. 2015 Jun 1;8(6):6269-86. eCollection 2015.

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Thymoquinone Ameliorates Cadmium-Induced Nephrotoxicity, Apoptosis, and Oxidative Stress in Rats is Based on its Anti-Apoptotic and Anti-Oxidant Properties.

Erboga M, Kanter M, Aktas C, Sener U, Fidanol Erboga Z, Bozdemir Donmez Y, Gurel A.

Biol Trace Elem Res. 2016 Mar;170(1):165-72. doi: 10.1007/s12011-015-0453-x. Epub 2015 Aug 1.

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Nigella sativa oil attenuates chronic nephrotoxicity induced by oral sodium nitrite: Effects on tissue fibrosis and apoptosis.

Al-Gayyar MM, Hassan HM, Alyoussef A, Abbas A, Darweish MM, El-Hawwary AA.

Redox Rep. 2016 Mar;21(2):50-60. doi: 10.1179/1351000215Y.0000000035. Epub 2016 Mar 10.

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Oxidative Stress Responses to Nigella sativa Oil Concurrent with a Low-Calorie Diet in Obese Women: A Randomized, Double-Blind Controlled Clinical Trial.

Namazi N, Mahdavi R, Alizadeh M, Farajnia S.

Phytother Res. 2015 Nov;29(11):1722-8. doi: 10.1002/ptr.5417. Epub 2015 Jul 14.

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Thymoquinone Inhibition of Acquisition and Expression of Alcohol-Induced Behavioral Sensitization.

Khan MS, Gohar A, Abbas G, Mahmood W, Rauf K, Sewell RD.

Phytother Res. 2015 Oct;29(10):1610-5. doi: 10.1002/ptr.5409. Epub 2015 Jul 14.

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Thymoquinone Inhibits IL-1β-Induced Inflammation in Human Osteoarthritis Chondrocytes by Suppressing NF-κB and MAPKs Signaling Pathway.

Wang D, Qiao J, Zhao X, Chen T, Guan D.

Inflammation. 2015 Dec;38(6):2235-41. doi: 10.1007/s10753-015-0206-1.

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Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation.

Umar S, Hedaya O, Singh AK, Ahmed S.

Toxicol Appl Pharmacol. 2015 Sep 15;287(3):299-305. doi: 10.1016/j.taap.2015.06.017. Epub 2015 Jun 29.

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Ameliorative effects of Nigella sativa on dyslipidemia.

Asgary S, Sahebkar A, Goli-Malekabadi N.

J Endocrinol Invest. 2015 Oct;38(10):1039-46. doi: 10.1007/s40618-015-0337-0. Epub 2015 Jul 2. Review.

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Anticancer activity of Nigella sativa (black seed) and its relationship with the thermal processing and quinone composition of the seed.

Agbaria R, Gabarin A, Dahan A, Ben-Shabat S.

Drug Des Devel Ther. 2015 Jun 18;9:3119-24. doi: 10.2147/DDDT.S82938. eCollection 2015.

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Synthesis, characterization and biocompatibility of silver nanoparticles synthesized from Nigella sativa leaf extract in comparison with chemical silver nanoparticles.

Amooaghaie R, Saeri MR, Azizi M.

Ecotoxicol Environ Saf. 2015 Oct;120:400-8. doi: 10.1016/j.ecoenv.2015.06.025. Epub 2015 Jun 26.

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Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: A comprehensive review.

Majdalawieh AF, Fayyad MW.

Int Immunopharmacol. 2015 Sep;28(1):295-304. doi: 10.1016/j.intimp.2015.06.023. Epub 2015 Jun 26. Review.

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Neuroprotective effects of Nigella sativa extracts during germination on central nervous system.

Islam MH, Ahmad IZ, Salman MT.

Pharmacogn Mag. 2015 May;11(Suppl 1):S182-9. doi: 10.4103/0973-1296.157729.

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Thymoquinone Protects against Myocardial Ischemic Injury by Mitigating Oxidative Stress and Inflammation.

Ojha S, Azimullah S, Mohanraj R, Sharma C, Yasin J, Arya DS, Adem A.

Evid Based Complement Alternat Med. 2015;2015:143629. doi: 10.1155/2015/143629. Epub 2015 May 25.

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Complementary and Alternative Medicine Use Among Patients With Chronic Kidney Disease and Kidney Transplant Recipients.

Osman NA, Hassanein SM, Leil MM, NasrAllah MM.

J Ren Nutr. 2015 Nov;25(6):466-71. doi: 10.1053/j.jrn.2015.04.009. Epub 2015 Jun 17.

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Phytochemical profile and larvicidal properties of seed essential oil from Nigella sativa L. (Ranunculaceae), against Aedes aegypti, Anopheles stephensi, and Culex quinquefasciatus (Diptera: Culicidae).

Raj GA, Chandrasekaran M, Krishnamoorthy S, Jayaraman M, Venkatesalu V.

Parasitol Res. 2015 Sep;114(9):3385-91. doi: 10.1007/s00436-015-4563-3. Epub 2015 Jun 20.

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Effects of thymoquinone on testicular structure and sperm production in male obese rats.

Tüfek NH, Altunkaynak ME, Altunkaynak BZ, Kaplan S.

Syst Biol Reprod Med. 2015;61(4):194-204. doi: 10.3109/19396368.2015.1044135. Epub 2015 Jun 4.

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Effects of Nigella sativa oil with a low-calorie diet on cardiometabolic risk factors in obese women: a randomized controlled clinical trial.

Mahdavi R, Namazi N, Alizadeh M, Farajnia S.

Food Funct. 2015 Jun;6(6):2041-8. doi: 10.1039/c5fo00316d.

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Antioxidant effect of supercritical CO2 extracted Nigella sativa L. seed extract on deep fried oil quality parameters.

Solati Z, Baharin BS.

J Food Sci Technol. 2015 Jun;52(6):3475-84. doi: 10.1007/s13197-014-1409-4. Epub 2014 May 20.

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Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling.

Thummuri D, Jeengar MK, Shrivastava S, Nemani H, Ramavat RN, Chaudhari P, Naidu VG.

Pharmacol Res. 2015 Sep;99:63-73. doi: 10.1016/j.phrs.2015.05.006. Epub 2015 May 28.

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416.

Comparative Studies on Polyphenolic Composition, Antioxidant and Diuretic Effects of Nigella sativa L. (Black Cumin) and Nigella damascena L. (Lady-in-a-Mist) Seeds.

Toma CC, Olah NK, Vlase L, Mogoșan C, Mocan A.

Molecules. 2015 May 26;20(6):9560-74. doi: 10.3390/molecules20069560.

417.

Toxicity of some plant extracts against vector of lymphatic filariasis, Culex pipiens.

Hasaballah AI.

J Egypt Soc Parasitol. 2015 Apr;45(1):183-92.

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Report-Isolation identification and control of vancomycin resistant Staphylococcus aureus.

Liaqat F, Sheikh AA, Nazir J, Hussain T, Rabbani M, Shaheen AY, Muhammad J.

Pak J Pharm Sci. 2015 May;28(3):997-1004.

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Potential inhibitory effect of herbal medicines on rat hepatic cytochrome P450 2D gene expression and metabolic activity.

Al-Jenoobi FI, Korashy HM, Ahad A, Raish M, Al-Mohizea AM, Alam MA, Al-Suwayeh SA, Alkharfy KM.

Pharmazie. 2014 Nov;69(11):799-803.

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Nigella sativa: A potential natural protective agent against cardiac dysfunction in patients with type 2 diabetes mellitus.

Bamosa A, Kaatabi H, Badar A, Al-Khadra A, Al Elq A, Abou-Hozaifa B, Lebda F, Al-Almaie S.

J Family Community Med. 2015 May-Aug;22(2):88-95. doi: 10.4103/2230-8229.155380.

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Physico-chemical stress induced amyloid formation in insulin: Amyloid characterization, cytotoxicity analysis against human neuroblastoma cell lines and its prevention using black seeds (Nigella sativa).

Khan MS, Tabrez S, Rabbani N, Oves M, Shah A, Alsenaidy MA, Al-Senaidy AM.

Chin J Integr Med. 2015 May 13. [Epub ahead of print]

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[Comparative analysis of natural and synthetic antimutagens as regulators of gene expression in human cells under exposure to ionizing radiation].

Mikhailov VF, Shishkina AA, Vasilyeva IM, Shulenina LV, Raeva NF, Rogozhin EA, Startsev MI, Zasukhina GD, Gromov SP, Alfimov MV.

Genetika. 2015 Feb;51(2):147-55. Russian.

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The effect of thymoquinone treatment on the combined renal and pulmonary toxicity of cisplatin and diesel exhaust particles.

Ali BH, Al Za’abi M, Shalaby A, Manoj P, Waly MI, Yasin J, Fahim M, Nemmar A.

Exp Biol Med (Maywood). 2015 Dec;240(12):1698-707. doi: 10.1177/1535370215579013. Epub 2015 Apr 28.

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Protective effects of ethanolic extract of Nigella sativa seed in paracetamol induced acute hepatotoxicity in vivo.

Kushwah DS, Salman MT, Singh P, Verma VK, Ahmad A.

Pak J Biol Sci. 2014 Apr;17(4):517-22.

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The Effects of Nigella Sativa Hydro-alcoholic Extract on Memory and Brain Tissues Oxidative Damage after Repeated Seizures in Rats.

Vafaee F, Hosseini M, Hassanzadeh Z, Edalatmanesh MA, Sadeghnia HR, Seghatoleslam M, Mousavi SM, Amani A, Shafei MN.

Iran J Pharm Res. 2015 Spring;14(2):547-57.

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The comparison of anticancer activity of thymoquinone and nanothymoquinone on human breast adenocarcinoma.

Dehghani H, Hashemi M, Entezari M, Mohsenifar A.

Iran J Pharm Res. 2015 Spring;14(2):539-46.

428.
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Evaluation of the protective effect of Nigella sativa extract and its primary active component thymoquinone against DMBA-induced breast cancer in female rats.

Linjawi SA, Khalil WK, Hassanane MM, Ahmed ES.

Arch Med Sci. 2015 Mar 16;11(1):220-9. doi: 10.5114/aoms.2013.33329. Epub 2013 Feb 28.

430.

The effects of Nigella sativa oil, thymoquinone, propolis, and caffeic acid phenethyl ester on radiation-induced cataract.

Demir E, Taysi S, Al B, Demir T, Okumus S, Saygili O, Saricicek E, Dirier A, Akan M, Tarakcioglu M, Bagci C.

Wien Klin Wochenschr. 2016 Dec;128(Suppl 8):587-595. doi: 10.1007/s00508-015-0736-4. Epub 2015 Apr 10.

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Effect of Nigella sativa fixed oil on ethanol toxicity in rats.

Pourbakhsh H, Taghiabadi E, Abnous K, Hariri AT, Hosseini SM, Hosseinzadeh H.

Iran J Basic Med Sci. 2014 Dec;17(12):1020-31.

432.

Thymoquinone, the main constituent of Nigella sativa, affects adenosine receptors in asthmatic guinea pigs.

Pejman L, Omrani H, Mirzamohammadi Z, Keyhanmanesh R.

Iran J Basic Med Sci. 2014 Dec;17(12):1012-9.

433.

Neuroprotective effect of thymoquinone in acrylamide-induced neurotoxicity in Wistar rats.

Mehri S, Shahi M, Razavi BM, Hassani FV, Hosseinzadeh H.

Iran J Basic Med Sci. 2014 Dec;17(12):1007-11.

434.

In vitro lethal effects of various extracts of Nigella sativa seed on hydatid cyst protoscoleces.

Mahmoudvand H, Asadi A, Harandi MF, Sharififar F, Jahanbakhsh S, Dezaki ES.

Iran J Basic Med Sci. 2014 Dec;17(12):1001-6.

435.
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Effect of Nigella sativa on ischemia-reperfusion induced rat kidney damage.

Havakhah S, Sadeghnia HR, Hajzadeh MA, Roshan NM, Shafiee S, Hosseinzadeh H, Mohareri N, Rad AK.

Iran J Basic Med Sci. 2014 Dec;17(12):986-92.

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Cardio-protective and anti-cancer therapeutic potential of Nigella sativa.

Shafiq H, Ahmad A, Masud T, Kaleem M.

Iran J Basic Med Sci. 2014 Dec;17(12):967-79. Review.

439.

The protective effect of Nigella sativa against liver injury: a review.

Mollazadeh H, Hosseinzadeh H.

Iran J Basic Med Sci. 2014 Dec;17(12):958-66. Review.

440.

Thymoquinone: an emerging natural drug with a wide range of medical applications.

Khader M, Eckl PM.

Iran J Basic Med Sci. 2014 Dec;17(12):950-7. Review.

441.

The relaxant effect of Nigella sativa on smooth muscles, its possible mechanisms and clinical applications.

Keyhanmanesh R, Gholamnezhad Z, Boskabady MH.

Iran J Basic Med Sci. 2014 Dec;17(12):939-49. Review.

442.

Black cumin (Nigella sativa) and its constituent (thymoquinone): a review on antimicrobial effects.

Forouzanfar F, Bazzaz BS, Hosseinzadeh H.

Iran J Basic Med Sci. 2014 Dec;17(12):929-38. Review.

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Diuretic activity of aqueous extract of Nigella sativa in albino rats.

Asif M, Jabeen Q, Abdul Majid AM, Atif M.

Acta Pol Pharm. 2015 Jan-Feb;72(1):129-35.

445.

Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: a systematic review.

Heshmati J, Namazi N.

Complement Ther Med. 2015 Apr;23(2):275-82. doi: 10.1016/j.ctim.2015.01.013. Epub 2015 Feb 9. Review.

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Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome — a double blind randomized controlled trial — TAK-MetS trial.

Amin F, Islam N, Anila N, Gilani AH.

Complement Ther Med. 2015 Apr;23(2):165-74. doi: 10.1016/j.ctim.2015.01.008. Epub 2015 Jan 14.

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Mechanistic perspectives on cancer chemoprevention/chemotherapeutic effects of thymoquinone.

Kundu J, Chun KS, Aruoma OI, Kundu JK.

Mutat Res. 2014 Oct;768:22-34. doi: 10.1016/j.mrfmmm.2014.05.003. Epub 2014 May 27. Review.

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A study of Nigella sativa induced growth inhibition of MCF and HepG2 cell lines: An anti-neoplastic study along with its mechanism of action.

Reddy YP, Chandrasekhar KB, Sadiq MJ.

Pharmacognosy Res. 2015 Apr-Jun;7(2):193-7. doi: 10.4103/0974-8490.150541.

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Thymoquinone and its therapeutic potentials.

Darakhshan S, Bidmeshki Pour A, Hosseinzadeh Colagar A, Sisakhtnezhad S.

Pharmacol Res. 2015 May-Jun;95-96:138-58. doi: 10.1016/j.phrs.2015.03.011. Epub 2015 Mar 28. Review.

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Thymoquinone inhibits lipopolysaccharide-induced inflammatory mediators in BV2 microglial cells.

Wang Y, Gao H, Zhang W, Zhang W, Fang L.

Int Immunopharmacol. 2015 May;26(1):169-73. doi: 10.1016/j.intimp.2015.03.013. Epub 2015 Mar 21.

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Chemopreventive and therapeutic potentials of thymoquinone in HepG2 cells: mechanistic perspectives.

ElKhoely A, Hafez HF, Ashmawy AM, Badary O, Abdelaziz A, Mostafa A, Shouman SA.

J Nat Med. 2015 Jul;69(3):313-23. doi: 10.1007/s11418-015-0895-7. Epub 2015 Mar 22.

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Effects of Nigella sativa on heat-induced testis damage in mouse.

Mohajeri D, Kaffashi Elahi R.

Bratisl Lek Listy. 2015;116(4):264-9.

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PEGylated-thymoquinone-nanoparticle mediated retardation of breast cancer cell migration by deregulation of cytoskeletal actin polymerization through miR-34a.

Bhattacharya S, Ahir M, Patra P, Mukherjee S, Ghosh S, Mazumdar M, Chattopadhyay S, Das T, Chattopadhyay D, Adhikary A.

Biomaterials. 2015 May;51:91-107. doi: 10.1016/j.biomaterials.2015.01.007. Epub 2015 Feb 17.

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The in vitro antifungal activity of sudanese medicinal plants against Madurella mycetomatis, the eumycetoma major causative agent.

Elfadil H, Fahal A, Kloezen W, Ahmed EM, van de Sande W.

PLoS Negl Trop Dis. 2015 Mar 13;9(3):e0003488. doi: 10.1371/journal.pntd.0003488. eCollection 2015 Mar.

455.

Effect of Nigella sativa Linn oil on tramadol-induced hepato- and nephrotoxicity in adult male albino rats.

Elkhateeb A, El Khishin I, Megahed O, Mazen F.

Toxicol Rep. 2015 Mar 14;2:512-519. doi: 10.1016/j.toxrep.2015.03.002. eCollection 2015.

456.

The protective effect of α-hederin, the active constituent of Nigella sativa, on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs.

Saadat S, Mohammadi M, Fallahi M, Keyhanmanesh R, Aslani MR.

J Physiol Sci. 2015 May;65(3):285-92. doi: 10.1007/s12576-015-0367-6. Epub 2015 Mar 10.

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Analysis and antibacterial activity of Nigella sativa essential oil formulated in microemulsion system.

Shaaban HA, Sadek Z, Edris AE, Saad-Hussein A.

J Oleo Sci. 2015;64(2):223-32. doi: 10.5650/jos.ess14177. Epub 2015 Jan 20.

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[Fatty acid composition of lipids of vegetative organs of Nigella at different levels of environment salinization].

Gogue DO, Sidorov RA, Tsydendambaev VD, Kholodova VP, Kuznetsov VV.

Izv Akad Nauk Ser Biol. 2014 May-Jun;(3):264-70. Russian.

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Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity.

Sultan MT, Butt MS, Karim R, Ahmad N, Ahmad RS, Ahmad W.

Pak J Pharm Sci. 2015 Mar;28(2):589-95.

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Nigella sativa improves glycemic control and ameliorates oxidative stress in patients with type 2 diabetes mellitus: placebo controlled participant blinded clinical trial.

Kaatabi H, Bamosa AO, Badar A, Al-Elq A, Abou-Hozaifa B, Lebda F, Al-Khadra A, Al-Almaie S.

PLoS One. 2015 Feb 23;10(2):e0113486. doi: 10.1371/journal.pone.0113486. eCollection 2015.

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Effects of fenugreek, Nigella, and termis seeds in nonalcoholic fatty liver in obese diabetic albino rats.

Mohamed WS, Mostafa AM, Mohamed KM, Serwah AH.

Arab J Gastroenterol. 2015 Mar;16(1):1-9. doi: 10.1016/j.ajg.2014.12.003. Epub 2015 Feb 7.

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Susceptibility characterisation of Candida spp. to four essential oils.

Rath CC, Mohapatra S.

Indian J Med Microbiol. 2015 Feb;33 Suppl:93-6. doi: 10.4103/0255-0857.150903.

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Effects of formaldehyde inhalation on humoral immunity and protective effect of Nigella sativa oil: An experimental study.

Sapmaz HI, Sarsılmaz M, Gödekmerdan A, Ögetürk M, Taş U, Köse E.

Toxicol Ind Health. 2016 Sep;32(9):1564-9. doi: 10.1177/0748233714566294. Epub 2015 Feb 4.

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Expression, immunogenicity and diagnostic value of envelope proteins from an Egyptian hepatitis C virus isolate.

Shawky H, Maghraby AS, Solliman Mel-D, El-Mokadem MT, Sherif MM, Arafa A, Bahgat MM.

Arch Virol. 2015 Apr;160(4):945-58. doi: 10.1007/s00705-015-2334-1. Epub 2015 Jan 29.

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Thymoquinone induces caspase-independent, autophagic cell death in CPT-11-resistant lovo colon cancer via mitochondrial dysfunction and activation of JNK and p38.

Chen MC, Lee NH, Hsu HH, Ho TJ, Tu CC, Hsieh DJ, Lin YM, Chen LM, Kuo WW, Huang CY.

J Agric Food Chem. 2015 Feb 11;63(5):1540-6. doi: 10.1021/jf5054063. Epub 2015 Feb 3.

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Synthesis, morphology and antifungal activity of nano-particulated amphotericin-B, ketoconazole and thymoquinone against Candida albicans yeasts and Candida biofilm.

Randhawa MA, Gondal MA, Al-Zahrani AH, Rashid SG, Ali A.

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2015;50(2):119-24. doi: 10.1080/10934529.2015.975042.

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Scolicidal effects of black cumin seed (Nigella sativa) essential oil on hydatid cysts.

Mahmoudvand H, Dezaki ES, Kheirandish F, Ezatpour B, Jahanbakhsh S, Harandi MF.

Korean J Parasitol. 2014 Dec;52(6):653-9. doi: 10.3347/kjp.2014.52.6.653. Epub 2014 Dec 23.

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Evaluation of antileishmanial activity and cytotoxicity of the extracts of Berberis vulgaris and Nigella sativa against Leishmania tropica.

Mahmoudvand H, Sharififar F, Rahmat MS, Tavakoli R, Dezaki ES, Jahanbakhsh S, Sharifi I.

J Vector Borne Dis. 2014 Dec;51(4):294-9.

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Enhanced cytotoxicity and apoptosis by thymoquinone in combination with zoledronic acid in hormone- and drug-resistant prostate cancer cell lines.

Dirican A, Erten C, Atmaca H, Bozkurt E, Kucukzeybek Y, Varol U, Oktay Tarhan M, Karaca B, Uslu R.

J BUON. 2014 Oct-Dec;19(4):1055-61.

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Thymoquinone inhibits murine leukemia WEHI-3 cells in vivo and in vitro.

Salim LZ, Othman R, Abdulla MA, Al-Jashamy K, Ali HM, Hassandarvish P, Dehghan F, Ibrahim MY, Omer FA, Mohan S.

PLoS One. 2014 Dec 22;9(12):e115340. doi: 10.1371/journal.pone.0115340. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0120034.

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Roles of p53 and caspases in induction of apoptosis in MCF- 7 breast cancer cells treated with a methanolic extract of Nigella sativa seeds.

Alhazmi MI, Hasan TN, Shafi G, Al-Assaf AH, Alfawaz MA, Alshatwi AA.

Asian Pac J Cancer Prev. 2014;15(22):9655-60.

474.

Antimicrobial activity of extracts from a Thai traditional remedy called Kabpi for oral and throat infection and its plant components.

Lairungruang K, Itharat A, Panthong S.

J Med Assoc Thai. 2014 Aug;97 Suppl 8:S108-15.

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Anti-diabetic activity of different oils through their effect on arylsulfatases.

Samarji R, Balbaa M.

J Diabetes Metab Disord. 2014 Dec 9;13(1):116. doi: 10.1186/s40200-014-0116-z. eCollection 2014.

476.

Elucidation of molecular targets of bioactive principles of black cumin relevant to its anti-tumour functionality — An Insilico target fishing approach.

Sridhar A, Saremy S, Bhattacharjee B.

Bioinformation. 2014 Nov 27;10(11):684-8. doi: 10.6026/97320630010684. eCollection 2014.

477.

Leishmanicidal and cytotoxic activities of Nigella sativa and its active principle, thymoquinone.

Mahmoudvand H, Tavakoli R, Sharififar F, Minaie K, Ezatpour B, Jahanbakhsh S, Sharifi I.

Pharm Biol. 2015 Jul;53(7):1052-7. doi: 10.3109/13880209.2014.957784. Epub 2014 Dec 4.

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Evaluation of antifungal activities of the essential oil and various extracts of Nigella sativa and its main component, thymoquinone against pathogenic dermatophyte strains.

Mahmoudvand H, Sepahvand A, Jahanbakhsh S, Ezatpour B, Ayatollahi Mousavi SA.

J Mycol Med. 2014 Dec;24(4):e155-61. doi: 10.1016/j.mycmed.2014.06.048. Epub 2014 Oct 19.

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Protective role of Nigella sativa oil against reproductive toxicity, hormonal alterations, and oxidative damage induced by chlorpyrifos in male rats.

Mosbah R, Yousef MI, Maranghi F, Mantovani A.

Toxicol Ind Health. 2016 Jul;32(7):1266-77. doi: 10.1177/0748233714554675. Epub 2014 Nov 25.

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In vivo and ex vivo evaluation of cosmetic properties of seedcakes.

Ratz-Łyko A, Arct J, Pytkowska K, Majewski S.

J Cosmet Laser Ther. 2015 Apr;17(2):109-15. doi: 10.3109/14764172.2014.988726. Epub 2014 Dec 22.

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Anti-microbial effect of Nigella sativa seed extract against staphylococcal skin Infection.

Rafati S, Niakan M, Naseri M.

Med J Islam Repub Iran. 2014 Jun 8;28:42. eCollection 2014.

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Effect of Nigella sativa on immune response in treadmill exercised rat.

Gholamnezhad Z, Boskabady MH, Hosseini M.

BMC Complement Altern Med. 2014 Nov 7;14:437. doi: 10.1186/1472-6882-14-437.

484.

Evaluation of Wound Closure Activity of Nigella sativa, Melastoma malabathricum, Pluchea indica, and Piper sarmentosum Extracts on Scratched Monolayer of Human Gingival Fibroblasts.

Ab Rahman MR, Abdul Razak F, Mohd Bakri M.

Evid Based Complement Alternat Med. 2014;2014:190342. doi: 10.1155/2014/190342. Epub 2014 Oct 13.

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Thymoquinone supplementation reverses lead-induced oxidative stress in adult rat testes.

Mabrouk A, Ben Cheikh H.

Gen Physiol Biophys. 2015 Jan;34(1):65-72. doi: 10.4149/gpb_2014022. Epub 2014 Nov 4.

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Protective effect of thymoquinone against high-fructose diet-induced metabolic syndrome in rats.

Prabhakar P, Reeta KH, Maulik SK, Dinda AK, Gupta YK.

Eur J Nutr. 2015 Oct;54(7):1117-27. doi: 10.1007/s00394-014-0788-7. Epub 2014 Oct 28.

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Thymoquinone Pretreatment Overcomes the Insensitivity and Potentiates the Antitumor Effect of Gemcitabine Through Abrogation of Notch1, PI3K/Akt/mTOR Regulated Signaling Pathways in Pancreatic Cancer.

Mu GG, Zhang LL, Li HY, Liao Y, Yu HG.

Dig Dis Sci. 2015 Apr;60(4):1067-80. doi: 10.1007/s10620-014-3394-x. Epub 2014 Oct 26.

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Anti-HIV-1 activity of eight monofloral Iranian honey types.

Behbahani M.

PLoS One. 2014 Oct 21;9(10):e108195. doi: 10.1371/journal.pone.0108195. eCollection 2014.

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Indazole-type alkaloids from Nigella sativa seeds exhibit antihyperglycemic effects via AMPK activation in vitro.

Yuan T, Nahar P, Sharma M, Liu K, Slitt A, Aisa HA, Seeram NP.

J Nat Prod. 2014 Oct 24;77(10):2316-20. doi: 10.1021/np500398m. Epub 2014 Oct 9.

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Effects of intraperitoneal thymoquinone on chronic neuropathic pain in rats.

Amin B, Taheri MM, Hosseinzadeh H.

Planta Med. 2014 Oct;80(15):1269-77. doi: 10.1055/s-0034-1383062. Epub 2014 Oct 1.

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Thymoquinone attenuates Doxorubicin-induced nephrotoxicity in rats: Role of Nrf2 and NOX4.

Elsherbiny NM, El-Sherbiny M.

Chem Biol Interact. 2014 Nov 5;223:102-8. doi: 10.1016/j.cbi.2014.09.015. Epub 2014 Sep 28.

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Effects of fenugreek, garden cress, and black seed on theophylline pharmacokinetics in beagle dogs.

Al-Jenoobi FI, Ahad A, Mahrous GM, Al-Mohizea AM, AlKharfy KM, Al-Suwayeh SA.

Pharm Biol. 2015 Feb;53(2):296-300. doi: 10.3109/13880209.2014.916312. Epub 2014 Sep 22.

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Apoptotic activities of thymoquinone, an active ingredient of black seed (Nigella sativa), in cervical cancer cell lines.

Ichwan SJ, Al-Ani IM, Bilal HG, Suriyah WH, Taher M, Ikeda MA.

Chin J Physiol. 2014 Oct 31;57(5):249-55. doi: 10.4077/CJP.2014.BAB190.

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Thymoquinone inhibits proliferation and invasion of human nonsmall-cell lung cancer cells via ERK pathway.

Yang J, Kuang XR, Lv PT, Yan XX.

Tumour Biol. 2015 Jan;36(1):259-69. doi: 10.1007/s13277-014-2628-z. Epub 2014 Sep 20.

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Nigella sativa Pretreatment in Guinea Pigs Exposed to Cigarette Smoke Modulates In Vitro Tracheal Responsiveness.

Keyhanmanesh R, Nazemiyeh H, Mazouchian H, Bagheri Asl MM, Karimi Shoar M, Alipour MR, Boskabady MH.

Iran Red Crescent Med J. 2014 Jul;16(7):e10421. doi: 10.5812/ircmj.10421. Epub 2014 Jul 5.

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Thymoquinone supplementation ameliorates lead-induced testis function impairment in adult rats.

Mabrouk A, Ben Cheikh H.

Toxicol Ind Health. 2016 Jun;32(6):1114-21. doi: 10.1177/0748233714548474. Epub 2014 Sep 12.

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Physicochemical and phytochemical standardization with HPTLC fingerprinting of Nigella sativa L. seeds.

Ahmad A, Husain A, Mujeeb M, Siddiqui NA, Damanhouri ZA, Bhandari A.

Pak J Pharm Sci. 2014 Sep;27(5):1175-82.

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Anxiolytic and hyperlocomotive effects of aqueous extract of Nigella sativa L. seeds in rats.

Bano F, Ahmed A, Parveen T, Haider S.

Pak J Pharm Sci. 2014 Sep;27(5 Spec no):1547-52.

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Monitoring in vitro antibacterial efficacy of 26 Indian spices against multidrug resistant urinary tract infecting bacteria.

Rath S, Padhy RN.

Integr Med Res. 2014 Sep;3(3):133-141. doi: 10.1016/j.imr.2014.04.002. Epub 2014 May 6.

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Nigella sativa oil reduces aluminium chloride-induced oxidative injury in liver and erythrocytes of rats.

Bouasla I, Bouasla A, Boumendjel A, Messarah M, Abdennour C, Boulakoud MS, El Feki A.

Biol Trace Elem Res. 2014 Dec;162(1-3):252-61. doi: 10.1007/s12011-014-0114-5. Epub 2014 Aug 28.

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Effect of dexamethasone and Nigella sativa on inducible nitric oxide synthase in the lungs of a murine model of allergic Asthma.

Abdel-Aziz M, Abass A, Zalata K, Abd Al-Galel T, Allam U, Karrouf G.

Iran J Allergy Asthma Immunol. 2014 Oct;13(5):324-34.

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GC-MS characterisation and antibacterial activity evaluation of Nigella sativa oil against diverse strains of Salmonella.

Sarwar A, Latif Z.

Nat Prod Res. 2015;29(5):447-51. doi: 10.1080/14786419.2014.947493. Epub 2014 Aug 22.

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Potential implications of GRP58 expression and susceptibility of cervical cancer to cisplatin and thymoquinone-based therapy.

Hafiza WA, Latifah SY.

Onco Targets Ther. 2014 Aug 7;7:1375-87. doi: 10.2147/OTT.S62928. eCollection 2014.

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A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome.

Razavi BM, Hosseinzadeh H.

J Endocrinol Invest. 2014 Nov;37(11):1031-40. doi: 10.1007/s40618-014-0150-1. Epub 2014 Aug 15. Review.

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Impact of Herbal Medicines like Nigella sativa, Trigonella foenum-graecum, and Ferula asafoetida, on Cytochrome P450 2C11 Gene Expression in Rat Liver.

Korashy HM, Al-Jenoobi FI, Raish M, Ahad A, Al-Mohizea AM, Alam MA, Alkharfy KM, Al-Suwayeh SA.

Drug Res (Stuttg). 2015 Jul;65(7):366-72. doi: 10.1055/s-0034-1384604. Epub 2014 Aug 6.

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The effects of Nigella sativa extract on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats.

Beheshti F, Hosseini M, Shafei MN, Soukhtanloo M, Ghasemi S, Vafaee F, Zarepoor L.

Nutr Neurosci. 2017 Jan;20(1):49-59. doi: 10.1179/1476830514Y.0000000144. Epub 2016 Mar 2.

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Potential protective effects of Nigella sativa and Allium sativum against fructose-induced metabolic syndrome in rats.

Al-Rasheed N, Al-Rasheed N, Bassiouni Y, Faddah L, Mohamad AM.

J Oleo Sci. 2014;63(8):839-48.

508.

Comparing Nigella sativa Oil and Fish Oil in Treatment of Vitiligo.

Ghorbanibirgani A, Khalili A, Rokhafrooz D.

Iran Red Crescent Med J. 2014 Jun;16(6):e4515. doi: 10.5812/ircmj.4515. Epub 2014 Jun 5.

509.

Protective effect of Nigella sativa oil against binge ethanol-induced oxidative stress and liver injury in rats.

Develi S, Evran B, Betül Kalaz E, Koçak-Toker N, Erata GÖ.

Chin J Nat Med. 2014 Jul;12(7):495-9. doi: 10.1016/S1875-5364(14)60077-7.

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510.

The effect of single dose of thymoquinone, the main constituents of Nigella sativa, in guinea pig model of asthma.

Keyhanmanesh R, Pejman L, Omrani H, Mirzamohammadi Z, Shahbazfar AA.

Bioimpacts. 2014;4(2):75-81. doi: 10.5681/bi.2014.006. Epub 2014 May 28.

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Bio-active nanoemulsions enriched with gold nanoparticle, marigold extracts and lipoic acid: In vitro investigations.

Guler E, Barlas FB, Yavuz M, Demir B, Gumus ZP, Baspinar Y, Coskunol H, Timur S.

Colloids Surf B Biointerfaces. 2014 Sep 1;121:299-306. doi: 10.1016/j.colsurfb.2014.05.026. Epub 2014 Jun 23.

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Thymoquinone induces cell death in human squamous carcinoma cells via caspase activation-dependent apoptosis and LC3-II activation-dependent autophagy.

Chu SC, Hsieh YS, Yu CC, Lai YY, Chen PN.

PLoS One. 2014 Jul 7;9(7):e101579. doi: 10.1371/journal.pone.0101579. eCollection 2014.

514.

Dietary supplementation of chloroquine with nigella sativa seed and oil extracts in the treatment of malaria induced in mice with plasmodium berghei.

Emeka PM, Badger-Emeka LI, Eneh CM, Khan TM.

Pharmacogn Mag. 2014 Apr;10(Suppl 2):S357-62. doi: 10.4103/0973-1296.133282.

515.

Effects of Nigella sativa (Habbatus sauda) Oil and Nicotine Chronic Treatments on Sperm Parameters and Testis Histological Features of Rats.

Cho Ping N, Hashim NH, Hasan Adli DS.

Evid Based Complement Alternat Med. 2014;2014:218293. doi: 10.1155/2014/218293. Epub 2014 May 21.

516.

Histological study on effect of Nigella sativa on aged olfactory system of female albino rat.

Eltony SA, Elgayar SA.

Rom J Morphol Embryol. 2014;55(2):325-34.

517.

The radioprotective effect of Nigella sativa on nitrosative stress in lens tissue in radiation-induced cataract in rat.

Taysi S, Abdulrahman ZK, Okumus S, Demir E, Demir T, Akan M, Saricicek E, Saricicek V, Aksoy A, Tarakcioglu M.

Cutan Ocul Toxicol. 2015;34(2):101-6. doi: 10.3109/15569527.2014.910802. Epub 2014 Jun 25.

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Therapeutic Implications of Black Seed and Its Constituent Thymoquinone in the Prevention of Cancer through Inactivation and Activation of Molecular Pathways.

Rahmani AH, Alzohairy MA, Khan MA, Aly SM.

Evid Based Complement Alternat Med. 2014;2014:724658. doi: 10.1155/2014/724658. Epub 2014 May 18. Review.

519.

Protective role of thymoquinone against liver damage induced by tamoxifen in female rats.

Suddek GM.

Can J Physiol Pharmacol. 2014 Aug;92(8):640-4. doi: 10.1139/cjpp-2014-0148. Epub 2014 May 26.

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520.

Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus.

Sultan MT, Butt MS, Karim R, Iqbal SZ, Ahmad S, Zia-Ul-Haq M, Aliberti L, Ahmad AN, De Feo V.

BMC Complement Altern Med. 2014 Jun 17;14:193. doi: 10.1186/1472-6882-14-193.

521.

Pharmacokinetic plasma behaviors of intravenous and oral bioavailability of thymoquinone in a rabbit model.

Alkharfy KM, Ahmad A, Khan RM, Al-Shagha WM.

Eur J Drug Metab Pharmacokinet. 2015 Sep;40(3):319-23. doi: 10.1007/s13318-014-0207-8. Epub 2014 Jun 13.

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522.

Endothelium-independent vasorelaxant effects of hydroalcoholic extract from Nigella sativa seed in rat aorta: the roles of Ca2+ and K+ channels.

Niazmand S, Fereidouni E, Mahmoudabady M, Mousavi SM.

Biomed Res Int. 2014;2014:247054. doi: 10.1155/2014/247054. Epub 2014 May 12.

523.

Thymoquinone induces apoptosis in human colon cancer HCT116 cells through inactivation of STAT3 by blocking JAK2- and Src‑mediated phosphorylation of EGF receptor tyrosine kinase.

Kundu J, Choi BY, Jeong CH, Kundu JK, Chun KS.

Oncol Rep. 2014 Aug;32(2):821-8. doi: 10.3892/or.2014.3223. Epub 2014 May 29.

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524.

A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional Sudanese plants with anti-diabetic potential.

Hilmi Y, Abushama MF, Abdalgadir H, Khalid A, Khalid H.

BMC Complement Altern Med. 2014 May 7;14:149. doi: 10.1186/1472-6882-14-149.

525.

Stable isotope dilution gas chromatography-mass spectrometry for quantification of thymoquinone in black cumin seed oil.

Johnson-Ajinwo OR, Li WW.

J Agric Food Chem. 2014 Jun 18;62(24):5466-71. doi: 10.1021/jf500357x. Epub 2014 Jun 5.

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526.

Antitrypanosomal screening and cytotoxic effects of selected medicinal plants.

Dyary HO, Arifah AK, Sharma RS, Rasedee A, Mohd-Aspollah MS, Zakaria ZA, Zuraini A, Somchit MN.

Trop Biomed. 2014 Mar;31(1):89-96.

527.

Intraperitoneal Nigella sativa for prevention of postoperative intra-abdominal adhesions in rats.

Karatas A, Ozlu T, Ozyalvacli G, Tosun M, Cetinkaya A, Donmez ME, Turker A, Bayrakdar H.

J Invest Surg. 2014 Dec;27(6):319-26. doi: 10.3109/08941939.2014.908988. Epub 2014 May 15.

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529.

Effects of Nigella sativa, Lepidium sativum and Trigonella foenum-graecum on sildenafil disposition in beagle dogs.

Al-Mohizea AM, Ahad A, El-Maghraby GM, Al-Jenoobi FI, AlKharfy KM, Al-Suwayeh SA.

Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):219-24. doi: 10.1007/s13318-014-0199-4. Epub 2014 Apr 11.

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530.

Screening of 20 commonly used Iranian traditional medicinal plants against urease.

Biglar M, Sufi H, Bagherzadeh K, Amanlou M, Mojab F.

Iran J Pharm Res. 2014 Winter;13(Suppl):195-8.

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Cellular uptake of Nigella sativa oil-PLGA microparticle by PC-12 cell line.

Doolaanea AA, Mansor N’, Mohd Nor NH, Mohamed F.

J Microencapsul. 2014;31(6):600-8. doi: 10.3109/02652048.2014.898709. Epub 2014 Apr 3.

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532.

Composition, in vitro antioxidant and antimicrobial activities of essential oil and oleoresins obtained from black cumin seeds (Nigella sativa L.).

Singh S, Das SS, Singh G, Schuff C, de Lampasona MP, Catalán CA.

Biomed Res Int. 2014;2014:918209. doi: 10.1155/2014/918209. Epub 2014 Feb 6.

533.

Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments.

Jamila F, Mostafa E.

J Ethnopharmacol. 2014 May 28;154(1):76-87. doi: 10.1016/j.jep.2014.03.016. Epub 2014 Mar 29.

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534.

A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women.

Ibrahim RM, Hamdan NS, Mahmud R, Imam MU, Saini SM, Rashid SN, Abd Ghafar SA, Latiff LA, Ismail M.

J Transl Med. 2014 Mar 31;12:82. doi: 10.1186/1479-5876-12-82.

535.

Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial.

Kolahdooz M, Nasri S, Modarres SZ, Kianbakht S, Huseini HF.

Phytomedicine. 2014 May 15;21(6):901-5. doi: 10.1016/j.phymed.2014.02.006. Epub 2014 Mar 25.

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536.

Radioprotective effects of Nigella sativa oil against oxidative stress in liver tissue of rats exposed to total head irradiation.

Cikman O, Ozkan A, Aras AB, Soylemez O, Alkis H, Taysi S, Karaayvaz M.

J Invest Surg. 2014 Oct;27(5):262-6. doi: 10.3109/08941939.2014.898811. Epub 2014 Mar 28.

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Natural products as topoisomerase II poisons: effects of thymoquinone on DNA cleavage mediated by human topoisomerase IIα.

Ashley RE, Osheroff N.

Chem Res Toxicol. 2014 May 19;27(5):787-93. doi: 10.1021/tx400453v. Epub 2014 Mar 31.

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Induction of apolipoprotein A-I gene expression by black seed (Nigella sativa) extracts.

Haas MJ, Onstead-Haas LM, Naem E, Wong NC, Mooradian AD.

Pharm Biol. 2014 Sep;52(9):1119-27. doi: 10.3109/13880209.2013.879187. Epub 2014 Mar 17.

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539.

Increased 5-HT Levels Following Repeated Administration of Nigella sativa L. (Black Seed) Oil Produce Antidepressant Effects in Rats.

Perveen T, Haider S, Zuberi NA, Saleem S, Sadaf S, Batool Z.

Sci Pharm. 2013 Nov 5;82(1):161-70. doi: 10.3797/scipharm.1304-19. Print 2014 Jan-Mar.

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The Effects of 8-week Nigella sativa Supplementation and Aerobic Training on Lipid Profile and VO2 max in Sedentary Overweight Females.

Farzaneh E, Nia FR, Mehrtash M, Mirmoeini FS, Jalilvand M.

Int J Prev Med. 2014 Feb;5(2):210-6.

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Thymoquinone induces G2/M arrest, inactivates PI3K/Akt and nuclear factor-κB pathways in human cholangiocarcinomas both in vitro and in vivo.

Xu D, Ma Y, Zhao B, Li S, Zhang Y, Pan S, Wu Y, Wang J, Wang D, Pan H, Liu L, Jiang H.

Oncol Rep. 2014 May;31(5):2063-70. doi: 10.3892/or.2014.3059. Epub 2014 Mar 5.

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Neuroprotective study of Nigella sativa-loaded oral provesicular lipid formulation: in vitro and ex vivo study.

Akhtar M, Imam SS, Afroz Ahmad M, Najmi AK, Mujeeb M, Aqil M.

Drug Deliv. 2014 Sep;21(6):487-94. doi: 10.3109/10717544.2014.886640. Epub 2014 Mar 7.

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543.

Effects of the hydro-alcoholic extract of Nigella sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism.

Hosseini M, Mohammadpour T, Karami R, Rajaei Z, Reza Sadeghnia H, Soukhtanloo M.

Chin J Integr Med. 2015 Jun;21(6):438-44. doi: 10.1007/s11655-014-1742-5. Epub 2014 Mar 2.

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545.

Cytotoxicity of Nigella sativa seed oil and extract against human lung cancer cell line.

Al-Sheddi ES, Farshori NN, Al-Oqail MM, Musarrat J, Al-Khedhairy AA, Siddiqui MA.

Asian Pac J Cancer Prev. 2014;15(2):983-7.

546.

Immunity: plants as effective mediators.

Sultan MT, Butt MS, Qayyum MM, Suleria HA.

Crit Rev Food Sci Nutr. 2014;54(10):1298-308. doi: 10.1080/10408398.2011.633249. Review.

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547.

Thymoquinone alleviates thioacetamide-induced hepatic fibrosis and inflammation by activating LKB1-AMPK signaling pathway in mice.

Bai T, Yang Y, Wu YL, Jiang S, Lee JJ, Lian LH, Nan JX.

Int Immunopharmacol. 2014 Apr;19(2):351-7. doi: 10.1016/j.intimp.2014.02.006. Epub 2014 Feb 22.

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548.

In vitro effect of Nigella sativa oil on adult Toxocara vitulorum.

Shalaby HA, El-Moghazy FM.

Pak J Biol Sci. 2013 Nov 15;16(22):1557-62.

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549.

Nigella sativa Fixed and Essential Oil Supplementation Modulates Hyperglycemia and Allied Complications in Streptozotocin-Induced Diabetes Mellitus.

Sultan MT, Butt MS, Karim R, Zia-Ul-Haq M, Batool R, Ahmad S, Aliberti L, De Feo V.

Evid Based Complement Alternat Med. 2014;2014:826380. doi: 10.1155/2014/826380. Epub 2014 Jan 8.

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Thymoquinone vapor significantly affects the results of Staphylococcus aureus sensitivity tests using the standard broth microdilution method.

Novy P, Kloucek P, Rondevaldova J, Havlik J, Kourimska L, Kokoska L.

Fitoterapia. 2014 Apr;94:102-7. doi: 10.1016/j.fitote.2014.01.024. Epub 2014 Feb 6.

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551.

Effect of Nigella sativa supplementation to exercise training in a novel model of physiological cardiac hypertrophy.

Al-Asoom LI, Al-Shaikh BA, Bamosa AO, El-Bahai MN.

Cardiovasc Toxicol. 2014 Sep;14(3):243-50. doi: 10.1007/s12012-014-9248-0.

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552.

Effect of dietary supplementation of black seed (N. Sativa L.) on lipid profile of patients suffering from diabetes.

Qidwai W, Ashfaq T.

Antiinflamm Antiallergy Agents Med Chem. 2014 Mar;13(1):3-8. Review.

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Anti-inflammatuar and anti-oxidative effects of Nigella sativa L.: 18FDG-PET imaging of inflammation.

Entok E, Ustuner MC, Ozbayer C, Tekin N, Akyuz F, Yangi B, Kurt H, Degirmenci I, Gunes HV.

Mol Biol Rep. 2014 May;41(5):2827-34. doi: 10.1007/s11033-014-3137-2. Epub 2014 Jan 29.

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554.

Nigella sativa is a safe herbal product.

Bamosa A.

J Integr Med. 2014 Jan;12(1):66. doi: 10.1016/S2095-4964(14)60007-8. No abstract available.

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555.

Nigella sativa Oil Enhances the Spatial Working Memory Performance of Rats on a Radial Arm Maze.

Sahak MK, Mohamed AM, Hashim NH, Hasan Adli DS.

Evid Based Complement Alternat Med. 2013;2013:180598. doi: 10.1155/2013/180598. Epub 2013 Dec 26.

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Comparison of Nigella sativa— and exercise-induced models of cardiac hypertrophy: structural and electrophysiological features.

Al-Asoom LI, Al-Shaikh BA, Bamosa AO, El-Bahai MN.

Cardiovasc Toxicol. 2014 Sep;14(3):208-13. doi: 10.1007/s12012-014-9244-4.

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557.

Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replication.

Chen C, Zuckerman DM, Brantley S, Sharpe M, Childress K, Hoiczyk E, Pendleton AR.

BMC Vet Res. 2014 Jan 16;10:24. doi: 10.1186/1746-6148-10-24.

558.

Metabolomics driven analysis of six Nigella species seeds via UPLC-qTOF-MS and GC-MS coupled to chemometrics.

Farag MA, Gad HA, Heiss AG, Wessjohann LA.

Food Chem. 2014 May 15;151:333-42. doi: 10.1016/j.foodchem.2013.11.032. Epub 2013 Nov 16.

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559.

Nigella Sativa reverses osteoporosis in ovariectomized rats.

Seif AA.

BMC Complement Altern Med. 2014 Jan 14;14:22. doi: 10.1186/1472-6882-14-22.

560.

The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes family.

Ulasli M, Gurses SA, Bayraktar R, Yumrutas O, Oztuzcu S, Igci M, Igci YZ, Cakmak EA, Arslan A.

Mol Biol Rep. 2014 Mar;41(3):1703-11. doi: 10.1007/s11033-014-3019-7. Epub 2014 Jan 12.

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Nigella sativa L. seeds modulate mood, anxiety and cognition in healthy adolescent males.

Bin Sayeed MS, Shams T, Fahim Hossain S, Rahman MR, Mostofa A, Fahim Kadir M, Mahmood S, Asaduzzaman M.

J Ethnopharmacol. 2014 Feb 27;152(1):156-62. doi: 10.1016/j.jep.2013.12.050. Epub 2014 Jan 8.

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562.

Protective Effects of Nigella sativa on Metabolic Syndrome in Menopausal Women.

Ibrahim RM, Hamdan NS, Ismail M, Saini SM, Abd Rashid SN, Abd Latiff L, Mahmud R.

Adv Pharm Bull. 2014;4(1):29-33. doi: 10.5681/apb.2014.005. Epub 2013 Dec 23.

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Topical Nigella Sativa for nasal symptoms in elderly.

Oysu C, Tosun A, Yilmaz HB, Sahin-Yilmaz A, Korkmaz D, Karaaslan A.

Auris Nasus Larynx. 2014 Jun;41(3):269-72. doi: 10.1016/j.anl.2013.12.002. Epub 2014 Jan 4.

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564.

Antihyperlipidemic effect of a polyherbal mixture in streptozotocin-induced diabetic rats.

Ghorbani A, Shafiee-Nick R, Rakhshandeh H, Borji A.

J Lipids. 2013;2013:675759. doi: 10.1155/2013/675759. Epub 2013 Dec 5.

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Thymoquinone induces heme oxygenase-1 expression in HaCaT cells via Nrf2/ARE activation: Akt and AMPKα as upstream targets.

Kundu J, Kim DH, Kundu JK, Chun KS.

Food Chem Toxicol. 2014 Mar;65:18-26. doi: 10.1016/j.fct.2013.12.015. Epub 2013 Dec 16.

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566.

Thymoquinone in the clinical treatment of cancer: Fact or fiction?

Abukhader MM.

Pharmacogn Rev. 2013 Jul;7(14):117-20. doi: 10.4103/0973-7847.120509. Review.

567.

Proapoptotic and antimetastatic properties of supercritical CO2 extract of Nigella sativa Linn. against breast cancer cells.

Baharetha HM, Nassar ZD, Aisha AF, Ahamed MB, Al-Suede FS, Abd Kadir MO, Ismail Z, Majid AM.

J Med Food. 2013 Dec;16(12):1121-30. doi: 10.1089/jmf.2012.2624.

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Authentication of Nigella sativa seed oil in binary and ternary mixtures with corn oil and soybean oil using FTIR spectroscopy coupled with partial least square.

Rohman A, Ariani R.

ScientificWorldJournal. 2013 Nov 11;2013:740142. doi: 10.1155/2013/740142. eCollection 2013.

569.

Neuroprotective effects of Nigella sativa extract on cell death in hippocampal neurons following experimental global cerebral ischemia-reperfusion injury in rats.

Hobbenaghi R, Javanbakht J, Sadeghzadeh Sh, Kheradmand D, Abdi FS, Jaberi MH, Mohammadiyan MR, Khadivar F, Mollaei Y.

J Neurol Sci. 2014 Feb 15;337(1-2):74-9. doi: 10.1016/j.jns.2013.11.019. Epub 2013 Nov 21.

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570.

Toxicity effect of nigella sativa on the liver function of rats.

Dollah MA, Parhizkar S, Latiff LA, Bin Hassan MH.

Adv Pharm Bull. 2013;3(1):97-102. doi: 10.5681/apb.2013.016. Epub 2013 Feb 7.

571.

Supplementary health benefits of linoleic Acid by improvement of vaginal cornification of ovariectomized rats.

Parhizkar S, Latiff LA.

Adv Pharm Bull. 2013;3(1):31-6. doi: 10.5681/apb.2013.006. Epub 2013 Feb 7.

572.

Nigella sativa concoction induced sustained seroreversion in HIV patient.

Onifade AA, Jewell AP, Adedeji WA.

Afr J Tradit Complement Altern Med. 2013 Aug 12;10(5):332-5. eCollection 2013.

573.

The Relaxant Effects of Different Methanolic Fractions of Nigella sativa on Guinea Pig Tracheal Chains.

Keyhanmanesh R, Bagban H, Nazemiyeh H, Mirzaei Bavil F, Alipour MR, Ahmady M.

Iran J Basic Med Sci. 2013 Feb;16(2):123-8.

574.

Thymoquinone causes multiple effects, including cell death, on dividing plant cells.

Hassanien SE, Ramadan AM, Azeiz AZ, Mohammed RA, Hassan SM, Shokry AM, Atef A, Kamal KB, Rabah S, Sabir JS, Abuzinadah OA, El-Domyati FM, Martin GB, Bahieldin A.

C R Biol. 2013 Nov-Dec;336(11-12):546-56. doi: 10.1016/j.crvi.2013.10.007. Epub 2013 Nov 19.

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575.

Radiation-modifying abilities of Nigella sativa and thymoquinone on radiation-induced nitrosative stress in the brain tissue.

Ahlatci A, Kuzhan A, Taysi S, Demirtas OC, Alkis HE, Tarakcioglu M, Demirci A, Caglayan D, Saricicek E, Cinar K.

Phytomedicine. 2014 Apr 15;21(5):740-4. doi: 10.1016/j.phymed.2013.10.023. Epub 2013 Nov 21.

PMID:
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576.

The effect of thymoquinone, an active component of Nigella sativa, on isoproterenol induced myocardial injury.

Randhawa MA, Alghamdi MS, Maulik SK.

Pak J Pharm Sci. 2013 Nov;26(6):1215-9.

PMID:
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577.

Anti-fibrotic effect of thymoquinone on hepatic stellate cells.

Ghazwani M, Zhang Y, Gao X, Fan J, Li J, Li S.

Phytomedicine. 2014 Feb 15;21(3):254-60. doi: 10.1016/j.phymed.2013.09.014. Epub 2013 Oct 30.

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578.

Nigella sativa extract affects conditioned place preference induced by morphine in rats.

Anvari M, Seddigh A, Shafei MN, Rakhshandeh H, Talebi AH, Tahani MR, Saeedjalali SM, Hosseini M.

Anc Sci Life. 2012 Oct;32(2):82-8. doi: 10.4103/0257-7941.118537.

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Effects of thymoquinone on STZ-induced diabetic nephropathy: an immunohistochemical study.

Omran OM.

Ultrastruct Pathol. 2014 Feb;38(1):26-33. doi: 10.3109/01913123.2013.830166. Epub 2013 Oct 17.

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580.

The effect of black seed (Nigella sativa) extract on FOXO3 expression in HepG2 cells.

Haas MJ, Onstead-Haas L, Naem E, Arnold A, Rohrbaugh N, Flowers M, Mooradian AD.

Phytother Res. 2014 Jun;28(6):873-9. doi: 10.1002/ptr.5069. Epub 2013 Oct 3.

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581.

Effect of Nigella sativa oil on postoperative peritoneal adhesion formation.

Sahbaz A, Ersan F, Aydin S.

J Obstet Gynaecol Res. 2014 Feb;40(2):532-7. doi: 10.1111/jog.12172. Epub 2013 Oct 7.

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Thymoquinone prevents β-amyloid neurotoxicity in primary cultured cerebellar granule neurons.

Ismail N, Ismail M, Mazlan M, Latiff LA, Imam MU, Iqbal S, Azmi NH, Ghafar SA, Chan KW.

Cell Mol Neurobiol. 2013 Nov;33(8):1159-69. doi: 10.1007/s10571-013-9982-z. Epub 2013 Oct 8.

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Thymoquinone inhibits tumor growth and induces apoptosis in a breast cancer xenograft mouse model: the role of p38 MAPK and ROS.

Woo CC, Hsu A, Kumar AP, Sethi G, Tan KH.

PLoS One. 2013 Oct 2;8(10):e75356. doi: 10.1371/journal.pone.0075356. eCollection 2013.

584.

Antipsoriatic activity and cytotoxicity of ethanolic extract of Nigella sativa seeds.

Dwarampudi LP, Palaniswamy D, Nithyanantham M, Raghu PS.

Pharmacogn Mag. 2012 Oct;8(32):268-72. doi: 10.4103/0973-1296.103650.

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Thymoquinone protects cultured hippocampal and human induced pluripotent stem cells-derived neurons against α-synuclein-induced synapse damage.

Alhebshi AH, Odawara A, Gotoh M, Suzuki I.

Neurosci Lett. 2014 Jun 6;570:126-31. doi: 10.1016/j.neulet.2013.09.049. Epub 2013 Sep 27.

PMID:
24080376
586.

Molecular targeting of Akt by thymoquinone promotes G(1) arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells.

Rajput S, Kumar BN, Dey KK, Pal I, Parekh A, Mandal M.

Life Sci. 2013 Nov 13;93(21):783-90. doi: 10.1016/j.lfs.2013.09.009. Epub 2013 Sep 15.

PMID:
24044882
587.

Thymoquinone inhibits autophagy and induces cathepsin-mediated, caspase-independent cell death in glioblastoma cells.

Racoma IO, Meisen WH, Wang QE, Kaur B, Wani AA.

PLoS One. 2013 Sep 9;8(9):e72882. doi: 10.1371/journal.pone.0072882. eCollection 2013.

588.

Thymoquinone induces mitochondria-mediated apoptosis in acute lymphoblastic leukaemia in vitro.

Salim LZ, Mohan S, Othman R, Abdelwahab SI, Kamalidehghan B, Sheikh BY, Ibrahim MY.

Molecules. 2013 Sep 12;18(9):11219-40. doi: 10.3390/molecules180911219.

589.

The investment in scent: time-resolved metabolic processes in developing volatile-producing Nigella sativa L. seeds.

Xue W, Batushansky A, Toubiana D, Botnick I, Szymanski J, Khozin-Goldberg I, Nikoloski Z, Lewinsohn E, Fait A.

PLoS One. 2013 Sep 3;8(9):e73061. doi: 10.1371/journal.pone.0073061. eCollection 2013.

590.

Thymoquinone inhibits cell proliferation through regulation of G1/S phase cell cycle transition in N-nitrosodiethylamine-induced experimental rat hepatocellular carcinoma.

Raghunandhakumar S, Paramasivam A, Senthilraja S, Naveenkumar C, Asokkumar S, Binuclara J, Jagan S, Anandakumar P, Devaki T.

Toxicol Lett. 2013 Oct 23;223(1):60-72. doi: 10.1016/j.toxlet.2013.08.018. Epub 2013 Sep 3.

PMID:
24012840
591.

Thymoquinone: fifty years of success in the battle against cancer models.

Schneider-Stock R, Fakhoury IH, Zaki AM, El-Baba CO, Gali-Muhtasib HU.

Drug Discov Today. 2014 Jan;19(1):18-30. doi: 10.1016/j.drudis.2013.08.021. Epub 2013 Aug 31. Review.

PMID:
24001594
592.

The clinical outcome of adjuvant therapy with black seed oil on intractable paediatric seizures: a pilot study.

Shawki M, El Wakeel L, Shatla R, El-Saeed G, Ibrahim S, Badary O.

Epileptic Disord. 2013 Sep;15(3):295-301. doi: 10.1684/epd.2013.0602.

593.

Effects of Nigella sativa and Lepidium sativum on cyclosporine pharmacokinetics.

Al-Jenoobi FI, Al-Suwayeh SA, Muzaffar I, Alam MA, Al-Kharfy KM, Korashy HM, Al-Mohizea AM, Ahad A, Raish M.

Biomed Res Int. 2013;2013:953520. doi: 10.1155/2013/953520. Epub 2013 Jul 16.

594.

Lepidium sativum but not Nigella sativa affects carbamazepine disposition in an animal model.

Alkharfy KM, Al-Jenoobi FI, Alam MA, Al-Mohizea AM, Al-Suwayeh SA, Korashy HM, Khan RM, Muzaffar I.

Drug Metab Lett. 2013 Mar;7(1):47-51.

PMID:
23952676
595.

Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: an experimental study with histopathological evaluation.

Alimohammadi S, Hobbenaghi R, Javanbakht J, Kheradmand D, Mortezaee R, Tavakoli M, Khadivar F, Akbari H.

Diagn Pathol. 2013 Aug 15;8:137. doi: 10.1186/1746-1596-8-137. Retraction in: Diagn Pathol. 2016 Nov 2;11(1):125.

596.

Pronounced transcriptional regulation of apoptotic and TNF-NF-kappa-B signaling genes during the course of thymoquinone mediated apoptosis in HeLa cells.

Sakalar C, Yuruk M, Kaya T, Aytekin M, Kuk S, Canatan H.

Mol Cell Biochem. 2013 Nov;383(1-2):243-51. doi: 10.1007/s11010-013-1772-x. Epub 2013 Aug 14.

PMID:
23943306
597.

Efficacy of Iranian traditional medicine in the treatment of epilepsy.

Abdollahi Fard M, Shojaii A.

Biomed Res Int. 2013;2013:692751. doi: 10.1155/2013/692751. Epub 2013 Jul 7. Review.

598.

Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo.

Kundu JK, Liu L, Shin JW, Surh YJ.

Biochem Biophys Res Commun. 2013 Sep 6;438(4):721-7. doi: 10.1016/j.bbrc.2013.07.110. Epub 2013 Aug 1.

PMID:
23911786
599.

Thymoquinone ameliorates lead-induced brain damage in Sprague Dawley rats.

Radad K, Hassanein K, Al-Shraim M, Moldzio R, Rausch WD.

Exp Toxicol Pathol. 2014 Jan;66(1):13-7. doi: 10.1016/j.etp.2013.07.002. Epub 2013 Jul 30.

PMID:
23910425
600.

Comparative effects of using black seed (Nigella sativa), cumin seed (Cuminum cyminum), probiotic or prebiotic on growth performance, blood haematology and serum biochemistry of broiler chicks.

Alimohamadi K, Taherpour K, Ghasemi HA, Fatahnia F.

J Anim Physiol Anim Nutr (Berl). 2014 Jun;98(3):538-46. doi: 10.1111/jpn.12115. Epub 2013 Aug 2.

PMID:
23909469

601 to 800 of 1126

 

601.

Effect of different levels of black cumin (Nigella sativa L.) on performance, intestinal Escherichia coli colonization and jejunal morphology in laying hens.

Boka J, Mahdavi AH, Samie AH, Jahanian R.

J Anim Physiol Anim Nutr (Berl). 2014 Apr;98(2):373-83. doi: 10.1111/jpn.12109. Epub 2013 Aug 2.

PMID:
23909404
602.

Cellular responses with thymoquinone treatment in human breast cancer cell line MCF-7.

Motaghed M, Al-Hassan FM, Hamid SS.

Pharmacognosy Res. 2013 Jul;5(3):200-6. doi: 10.4103/0974-8490.112428.

603.

Evaluation of topical black seed oil in the treatment of allergic rhinitis.

Alsamarai AM, Abdulsatar M, Ahmed Alobaidi AH.

Antiinflamm Antiallergy Agents Med Chem. 2014 Mar;13(1):75-82.

PMID:
23855426
604.
605.

Nigella sativa attenuates myocardial ischemic reperfusion injury in rats.

Seif AA.

J Physiol Biochem. 2013 Dec;69(4):937-44. doi: 10.1007/s13105-013-0272-5. Epub 2013 Jul 12.

PMID:
23846789
606.

Sensibility of male rats fertility against olive oil, Nigella sativa oil and pomegranate extract.

Mansour SW, Sangi S, Harsha S, Khaleel MA, Ibrahim AR.

Asian Pac J Trop Biomed. 2013 Jul;3(7):563-8. doi: 10.1016/S2221-1691(13)60114-8.

607.

Combinatorial Effects of Thymoquinone on the Anticancer Activity and Hepatotoxicity of the Prodrug CB 1954.

Talib WH, Abukhader MM.

Sci Pharm. 2013 Apr-Jun;81(2):519-30. doi: 10.3797/scipharm.1211-15. Epub 2013 Jan 3.

608.

Neuroprotective effects of chloroform and petroleum ether extracts of Nigella sativa seeds in stroke model of rat.

Akhtar M, Maikiyo AM, Najmi AK, Khanam R, Mujeeb M, Aqil M.

J Pharm Bioallied Sci. 2013 Apr;5(2):119-25. doi: 10.4103/0975-7406.111825.

609.

Thymoquinone-loaded nanostructured lipid carriers: preparation, gastroprotection, in vitro toxicity, and pharmacokinetic properties after extravascular administration.

Abdelwahab SI, Sheikh BY, Taha MM, How CW, Abdullah R, Yagoub U, El-Sunousi R, Eid EE.

Int J Nanomedicine. 2013;8:2163-72. doi: 10.2147/IJN.S44108. Epub 2013 Jun 17.

610.

HPLC-DAD determination of seven antioxidants and caffeine in different phytopharmaceuticals.

Hadad GM, Abdel Salam RA, Soliman RM, Mesbah MK.

J Chromatogr Sci. 2014 Aug;52(7):617-23. doi: 10.1093/chromsci/bmt086. Epub 2013 Jun 27.

PMID:
23811048
611.

Study on the potential toxicity of a thymoquinone-rich fraction nanoemulsion in Sprague Dawley rats.

Tubesha Z, Imam MU, Mahmud R, Ismail M.

Molecules. 2013 Jun 26;18(7):7460-72. doi: 10.3390/molecules18077460.

612.

Thymoquinone-induced reactive oxygen species causes apoptosis of chondrocytes via PI3K/Akt and p38kinase pathway.

Yu SM, Kim SJ.

Exp Biol Med (Maywood). 2013 Jul;238(7):811-20. doi: 10.1177/1535370213492685. Epub 2013 Jun 20.

PMID:
23788172
613.

A systematic review of anti-obesity medicinal plants — an update.

Hasani-Ranjbar S, Jouyandeh Z, Abdollahi M.

J Diabetes Metab Disord. 2013 Jun 19;12(1):28. doi: 10.1186/2251-6581-12-28.

615.

The main relaxant constituents of Nigella sativa methanolic fraction on Guinea pig tracheal chains.

Keyhanmanesh R, Bagban H, Nazemieh H, Mirzaei Bavil F, Alipour MR.

Iran J Allergy Asthma Immunol. 2013 May 15;12(2):136-43.

616.

Histopathological investigation of neuroprotective effects of Nigella sativa on motor neurons anterior horn spinal cord after sciatic nerve crush in rats.

Javanbakht J, Hobbenaghi R, Hosseini E, Bahrami AM, Khadivar F, Fathi S, Hassan MA.

Pathol Biol (Paris). 2013 Dec;61(6):250-3. doi: 10.1016/j.patbio.2013.03.007. Epub 2013 Jun 14.

PMID:
23751360
617.

Redox cycling of endogenous copper by thymoquinone leads to ROS-mediated DNA breakage and consequent cell death: putative anticancer mechanism of antioxidants.

Zubair H, Khan HY, Sohail A, Azim S, Ullah MF, Ahmad A, Sarkar FH, Hadi SM.

Cell Death Dis. 2013 Jun 6;4:e660. doi: 10.1038/cddis.2013.172.

618.

Radioprotection by Macerated Extract of Nigella sativa in Normal Tissues of Fibrosarcoma Bearing Mice.

Velho-Pereira R, Kumar A, Pandey BN, Mishra KP, Jagtap AG.

Indian J Pharm Sci. 2012 Sep;74(5):403-14. doi: 10.4103/0250-474X.108415.

619.

Thymoquinone induces apoptosis in oral cancer cells through p38β inhibition.

Abdelfadil E, Cheng YH, Bau DT, Ting WJ, Chen LM, Hsu HH, Lin YM, Chen RJ, Tsai FJ, Tsai CH, Huang CY.

Am J Chin Med. 2013;41(3):683-96. doi: 10.1142/S0192415X1350047X.

PMID:
23711149
620.

The effect of Nigella sativa Linn. seed on memory, attention and cognition in healthy human volunteers.

Bin Sayeed MS, Asaduzzaman M, Morshed H, Hossain MM, Kadir MF, Rahman MR.

J Ethnopharmacol. 2013 Jul 30;148(3):780-6. doi: 10.1016/j.jep.2013.05.004. Epub 2013 May 21.

PMID:
23707331
621.

Expression profiling of bioactive genes from a medicinal plant Nigella sativa L.

Falak S, Jamil A.

Appl Biochem Biotechnol. 2013 Jul;170(6):1472-81. doi: 10.1007/s12010-013-0281-4. Epub 2013 May 18. Erratum in: Appl Biochem Biotechnol. 2013 Sep;171(2):553.

PMID:
23686472
622.

Effects of Nigella sativa on outcome of hepatitis C in Egypt.

Barakat EM, El Wakeel LM, Hagag RS.

World J Gastroenterol. 2013 Apr 28;19(16):2529-36. doi: 10.3748/wjg.v19.i16.2529.

623.

Thymoquinone attenuates tumor growth in ApcMin mice by interference with Wnt-signaling.

Lang M, Borgmann M, Oberhuber G, Evstatiev R, Jimenez K, Dammann KW, Jambrich M, Khare V, Campregher C, Ristl R, Gasche C.

Mol Cancer. 2013 May 13;12(1):41. doi: 10.1186/1476-4598-12-41.

624.

Nigella sativa seed extract: 1. Enhancement of sheep macrophage immune functions in vitro.

Elmowalid G, Amar AM, Ahmad AA.

Res Vet Sci. 2013 Oct;95(2):437-43. doi: 10.1016/j.rvsc.2013.02.015. Epub 2013 May 7.

PMID:
23664216
625.

A review on therapeutic potential of Nigella sativa: A miracle herb.

Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F.

Asian Pac J Trop Biomed. 2013 May;3(5):337-52. doi: 10.1016/S2221-1691(13)60075-1. Review.

626.

Isolation of volatiles from Nigella sativa seeds using microwave-assisted extraction: effect of whole extracts on canine and murine CYP1A.

Liu X, Park JH, Abd El-Aty AM, Assayed ME, Shimoda M, Shim JH.

Biomed Chromatogr. 2013 Jul;27(7):938-45. doi: 10.1002/bmc.2887. Epub 2013 Apr 30.

PMID:
23629843
627.

In vivo modulation of iNOS pathway in hepatocellular carcinoma by Nigella sativa.

Fathy M, Nikaido T.

Environ Health Prev Med. 2013 Sep;18(5):377-85. doi: 10.1007/s12199-013-0336-8. Epub 2013 Apr 23.

628.

In Vitro Evaluations of Cytotoxicity of Eight Antidiabetic Medicinal Plants and Their Effect on GLUT4 Translocation.

Kadan S, Saad B, Sasson Y, Zaid H.

Evid Based Complement Alternat Med. 2013;2013:549345. doi: 10.1155/2013/549345. Epub 2013 Mar 28.

629.

Effects of selected bioactive natural products on the vascular endothelium.

Ahmad A, Khan RM, Alkharfy KM.

J Cardiovasc Pharmacol. 2013 Aug;62(2):111-21. doi: 10.1097/FJC.0b013e3182927e47. Review.

PMID:
23599064
630.

Effects of black cumin seed (Nigella sativa L.) on performance and immune system in newly evolved crossbred laying hens.

Khan SH, Anjum MA, Parveen A, Khawaja T, Ashraf NM.

Vet Q. 2013;33(1):13-9. doi: 10.1080/01652176.2013.782119. Erratum in: Vet Q. 2013;33(1):iii.

PMID:
23594164
631.

Hepatoprotective and immunological functions of Nigella sativa seed oil against hypervitaminosis A in adult male rats.

Al-Suhaimi EA.

Int J Vitam Nutr Res. 2012 Aug;82(4):288-97. doi: 10.1024/0300-9831/a000121.

PMID:
23591666
632.

Thymoquinone suppresses metastasis of melanoma cells by inhibition of NLRP3 inflammasome.

Ahmad I, Muneer KM, Tamimi IA, Chang ME, Ata MO, Yusuf N.

Toxicol Appl Pharmacol. 2013 Jul 1;270(1):70-6. doi: 10.1016/j.taap.2013.03.027. Epub 2013 Apr 10.

PMID:
23583630
633.

Synthesis, characterization and anti-tumor activity of novel thymoquinone analogs against pancreatic cancer.

Yusufi M, Banerjee S, Mohammad M, Khatal S, Venkateswara Swamy K, Khan EM, Aboukameel A, Sarkar FH, Padhye S.

Bioorg Med Chem Lett. 2013 May 15;23(10):3101-4. doi: 10.1016/j.bmcl.2013.03.003. Epub 2013 Mar 14.

PMID:
23562242
634.

Phosphorylated IκBα predicts poor prognosis in activated B-cell lymphoma and its inhibition with thymoquinone induces apoptosis via ROS release.

Hussain AR, Uddin S, Ahmed M, Al-Dayel F, Bavi PP, Al-Kuraya KS.

PLoS One. 2013;8(3):e60540. doi: 10.1371/journal.pone.0060540. Epub 2013 Mar 28.

635.

Effects of black seed oil on resolution of hepato-renal toxicity induced bybromobenzene in rats.

Hamed MA, El-Rigal NS, Ali SA.

Eur Rev Med Pharmacol Sci. 2013 Mar;17(5):569-81.

636.

Effect of Nigella sativa on the kidney function in rats.

Dollah MA, Parhizkar S, Izwan M.

Avicenna J Phytomed. 2013 Spring;3(2):152-8.

637.

Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity.

Alhebshi AH, Gotoh M, Suzuki I.

Biochem Biophys Res Commun. 2013 Apr 19;433(4):362-7. doi: 10.1016/j.bbrc.2012.11.139. Epub 2013 Mar 26.

PMID:
23537659
638.

Nigella sativa and Its Protective Role in Oxidative Stress and Hypertension.

Leong XF, Rais Mustafa M, Jaarin K.

Evid Based Complement Alternat Med. 2013;2013:120732. doi: 10.1155/2013/120732. Epub 2013 Mar 7. Erratum in: Evid Based Complement Alternat Med. 2013;2013:253479.

639.

Anti-Candida zeylanoides activity of some Iranian plants used in traditional medicine.

Shokri H, Sharifzadeh A, Ashrafi Tamai I.

J Mycol Med. 2012 Sep;22(3):211-6. doi: 10.1016/j.mycmed.2012.04.006. Epub 2012 Aug 9.

PMID:
23518076
640.

Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis.

Hasan TN, Shafi G, Syed NA, Alfawaz MA, Alsaif MA, Munshi A, Lei KY, Alshatwi AA.

Nat Prod Commun. 2013 Feb;8(2):213-6.

PMID:
23513732
641.

Re: Effect of alcoholic extract of Nigella sativa on cisplatin-induced toxicity in rat.

Nematbakhsh M, Nasri H.

Iran J Kidney Dis. 2013 Mar;7(2):165-6. No abstract available.

642.

A case study report of acute renal failure associated with Nigella sativa in a diabetic patient.

Arslan E, Sayin S, Demirbas S, Cakar M, Somak NG, Yesilkaya S, Saglam K.

J Integr Med. 2013 Jan;11(1):64-6. doi: 10.3736/jintegrmed2013010. No abstract available.

PMID:
23464648
643.

Radio-protective effects of Nigella sativa oil on oxidative stress in tongue tissue of rats.

Üstün K, Taysı S, Sezer U, Demir E, Baysal E, Demir T, Sarıçiçek E, Alkış H, Senyurt SZ, Tarakçıoğlu M, Aksoy N.

Oral Dis. 2014 Jan;20(1):109-13. doi: 10.1111/odi.12082. Epub 2013 Feb 28.

PMID:
23444976
644.

Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial.

Fallah Huseini H, Amini M, Mohtashami R, Ghamarchehre ME, Sadeqhi Z, Kianbakht S, Fallah Huseini A.

Phytother Res. 2013 Dec;27(12):1849-53. doi: 10.1002/ptr.4944. Epub 2013 Feb 25.

PMID:
23436437
645.

Effect of aqueous and ethanolic extracts of Nigella sativa seeds on milk production in rats.

Hosseinzadeh H, Tafaghodi M, Mosavi MJ, Taghiabadi E.

J Acupunct Meridian Stud. 2013 Feb;6(1):18-23. doi: 10.1016/j.jams.2012.07.019. Epub 2012 Aug 11.

646.
647.

Effects of Lepidium sativum, Nigella sativa and Trigonella foenum-graceum on phenytoin pharmacokinetics in beagle dogs.

Alkharfy KM, Al-Jenoobi FI, Al-Mohizea AM, Al-Suwayeh SA, Khan RM, Ahmad A.

Phytother Res. 2013 Dec;27(12):1800-4. doi: 10.1002/ptr.4947. Epub 2013 Feb 11.

PMID:
23401262
648.

Prevalence, hematology, and treatment of balantidiasis among donkeys in and around Lahore, Pakistan.

Khan A, Khan MS, Avais M, Ijaz M, Ali MM, Abbas T.

Vet Parasitol. 2013 Sep 1;196(1-2):203-5. doi: 10.1016/j.vetpar.2013.01.017. Epub 2013 Jan 30.

PMID:
23394797
649.

Treating Cryptosporidium parvum infection in calves.

Nasir A, Avais M, Khan MS, Khan JA, Hameed S, Reichel MP.

J Parasitol. 2013 Aug;99(4):715-7. doi: 10.1645/12-42.1. Epub 2013 Jan 24.

PMID:
23347204
650.

Thymoquinone accelerates osteoblast differentiation and activates bone morphogenetic protein-2 and ERK pathway.

Wirries A, Schubert AK, Zimmermann R, Jabari S, Ruchholtz S, El-Najjar N.

Int Immunopharmacol. 2013 Feb;15(2):381-6. doi: 10.1016/j.intimp.2012.12.033. Epub 2013 Jan 16.

PMID:
23333454
651.

Chemical composition and fatty acid content of some spices and herbs under Saudi Arabia conditions.

Al-Jasass FM, Al-Jasser MS.

ScientificWorldJournal. 2012;2012:859892. doi: 10.1100/2012/859892. Epub 2012 Dec 24.

652.

Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells.

Bai T, Lian LH, Wu YL, Wan Y, Nan JX.

Int Immunopharmacol. 2013 Feb;15(2):275-81. doi: 10.1016/j.intimp.2012.12.020. Epub 2013 Jan 12.

PMID:
23318601
653.

Antiproliferative properties of methanolic extract of Nigella sativa against the MDA-MB-231 cancer cell line.

Dilshad A, Abulkhair O, Nemenqani D, Tamimi W.

Asian Pac J Cancer Prev. 2012;13(11):5839-42.

654.

Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats.

Shafiee-Nick R, Ghorbani A, Vafaee Bagheri F, Rakhshandeh H.

Adv Pharmacol Sci. 2012;2012:789796. doi: 10.1155/2012/789796. Epub 2012 Dec 9.

655.

Traditional and spiritual medicine among Sudanese children with epilepsy.

Mohammed IN, Babikir HE.

Sudan J Paediatr. 2013;13(1):31-7.

656.

Beneficial therapeutic effects of Nigella sativa and/or Zingiber officinale in HCV patients in Egypt.

Abdel-Moneim A, Morsy BM, Mahmoud AM, Abo-Seif MA, Zanaty MI.

EXCLI J. 2013 Nov 11;12:943-55. eCollection 2013.

657.

Antioxidant effect of garlic (Allium sativum) and black seeds (Nigella sativa) in healthy postmenopausal women.

Mostafa RM, Moustafa YM, Mirghani Z, AlKusayer GM, Moustafa KM.

SAGE Open Med. 2013 Dec 24;1:2050312113517501. doi: 10.1177/2050312113517501. eCollection 2013.

658.

Anti-inflammatory effect of seeds and callus of Nigella sativa L. extracts on mix glial cells with regard to their thymoquinone content.

Alemi M, Sabouni F, Sanjarian F, Haghbeen K, Ansari S.

AAPS PharmSciTech. 2013 Mar;14(1):160-7. doi: 10.1208/s12249-012-9899-8. Epub 2012 Dec 19.

659.

A study of the effect of Nigella sativa (Black seeds) in isoniazid (INH)-induced hepatotoxicity in rabbits.

Hassan AS, Ahmed JH, Al-Haroon SS.

Indian J Pharmacol. 2012 Nov-Dec;44(6):678-82. doi: 10.4103/0253-7613.103239.

660.

Anti-Inflammatory Activity Is a Possible Mechanism by Which the Polyherbal Formulation Comprised of Nigella sativa (Seeds), Hemidesmus indicus (Root), and Smilax glabra (Rhizome) Mediates Its Antihepatocarcinogenic Effects.

Galhena PB, Samarakoon SR, Thabrew MI, Weerasinghe GA, Thammitiyagodage MG, Ratnasooriya WD, Tennekoon KH.

Evid Based Complement Alternat Med. 2012;2012:108626. doi: 10.1155/2012/108626. Epub 2012 Nov 13.

661.

Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin.

Mahmoud SS, Torchilin VP.

Cell Biochem Biophys. 2013 Jul;66(3):451-60. doi: 10.1007/s12013-012-9493-4.

PMID:
23242945
662.

Antitumor and anti-angiogenesis effects of thymoquinone on osteosarcoma through the NF-κB pathway.

Peng L, Liu A, Shen Y, Xu HZ, Yang SZ, Ying XZ, Liao W, Liu HX, Lin ZQ, Chen QY, Cheng SW, Shen WD.

Oncol Rep. 2013 Feb;29(2):571-8. doi: 10.3892/or.2012.2165. Epub 2012 Dec 4.

PMID:
23232982
663.

Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients.

Kaatabi H, Bamosa AO, Lebda FM, Al Elq AH, Al-Sultan AI.

J Family Community Med. 2012 Sep;19(3):155-61. doi: 10.4103/2230-8229.102311.

664.

Polo-like kinase 1 as target for cancer therapy.

Weiß L, Efferth T.

Exp Hematol Oncol. 2012 Dec 10;1(1):38. doi: 10.1186/2162-3619-1-38.

665.

Efficiency of black cumin seeds on hematological factors in normal and hypercholesterolemic rabbits.

Asgary S, Najafi S, Ghannadi A, Dashti G, Helalat A.

ARYA Atheroscler. 2012 Winter;7(4):146-50.

666.

Comparison of therapeutic effect of topical Nigella with Betamethasone and Eucerin in hand eczema.

Yousefi M, Barikbin B, Kamalinejad M, Abolhasani E, Ebadi A, Younespour S, Manouchehrian M, Hejazi S.

J Eur Acad Dermatol Venereol. 2013 Dec;27(12):1498-504. doi: 10.1111/jdv.12033. Epub 2012 Dec 1.

PMID:
23198836
667.

Dietary practices of Saudi women during puerperium.

Saadia Z, Roshdy S, Sagir F, Abidin S.

J Obstet Gynaecol Res. 2013 Apr;39(4):799-805. doi: 10.1111/j.1447-0756.2012.02035.x. Epub 2012 Oct 29.

PMID:
23106949
668.

Evaluation of the possible epileptogenic activity of ciprofloxacin: the role of Nigella sativa on amino acids neurotransmitters.

Arafa NM, Abdel-Rahman M, El-khadragy MF, Kassab RB.

Neurochem Res. 2013 Jan;38(1):174-85. doi: 10.1007/s11064-012-0905-z. Epub 2012 Oct 21.

PMID:
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669.

Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma.

Das S, Dey KK, Dey G, Pal I, Majumder A, MaitiChoudhury S, kundu SC, Mandal M.

PLoS One. 2012;7(10):e46641. doi: 10.1371/journal.pone.0046641. Epub 2012 Oct 15.

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Thymoquinone: Novel gastroprotective mechanisms.

Magdy MA, Hanan el-A, Nabila el-M.

Eur J Pharmacol. 2012 Dec 15;697(1-3):126-31. doi: 10.1016/j.ejphar.2012.09.042. Epub 2012 Oct 7.

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Physicochemical and antioxidant properties of Bangladeshi honeys stored for more than one year.

Islam A, Khalil I, Islam N, Moniruzzaman M, Mottalib A, Sulaiman SA, Gan SH.

BMC Complement Altern Med. 2012 Oct 8;12:177. doi: 10.1186/1472-6882-12-177.

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Nigella sativa oil as a pulp medicament for pulpotomized teeth: a histopathological evaluation.

Omar OM, Khattab NM, Khater DS.

J Clin Pediatr Dent. 2012 Summer;36(4):335-41.

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Nephro-protective effect of vitamin C and Nigella sativa oil on gentamicin associated nephrotoxicity in rabbits.

Saleem U, Ahmad B, Rehman K, Mahmood S, Alam M, Erum A.

Pak J Pharm Sci. 2012 Oct;25(4):727-30.

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Nigella sativa: A Potential Antiosteoporotic Agent.

Shuid AN, Mohamed N, Mohamed IN, Othman F, Suhaimi F, Mohd Ramli ES, Muhammad N, Soelaiman IN.

Evid Based Complement Alternat Med. 2012;2012:696230. doi: 10.1155/2012/696230. Epub 2012 Sep 3.

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NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis.

Sutton KM, Doucette CD, Hoskin DW.

Biochem Biophys Res Commun. 2012 Sep 28;426(3):421-6. doi: 10.1016/j.bbrc.2012.08.111. Epub 2012 Aug 30.

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The effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide — induced depression like behavior in rats.

Hosseini M, Zakeri S, Khoshdast S, Yousefian FT, Rastegar M, Vafaee F, Kahdouee S, Ghorbani F, Rakhshandeh H, Kazemi SA.

J Pharm Bioallied Sci. 2012 Jul;4(3):219-25. doi: 10.4103/0975-7406.99052.

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Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses.

Botnick I, Xue W, Bar E, Ibdah M, Schwartz A, Joel DM, Lev E, Fait A, Lewinsohn E.

Molecules. 2012 Aug 24;17(9):10159-77. doi: 10.3390/molecules170910159.

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Cardiovascular benefits of black cumin (Nigella sativa).

Shabana A, El-Menyar A, Asim M, Al-Azzeh H, Al Thani H.

Cardiovasc Toxicol. 2013 Mar;13(1):9-21. doi: 10.1007/s12012-012-9181-z. Review.

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Use of complementary and alternative medicine by patients with cancer in Saudi Arabia.

Jazieh AR, Al Sudairy R, Abulkhair O, Alaskar A, Al Safi F, Sheblaq N, Young S, Issa M, Tamim H.

J Altern Complement Med. 2012 Nov;18(11):1045-9. doi: 10.1089/acm.2011.0266. Epub 2012 Aug 20.

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Antagonism between curcumin and the topoisomerase II inhibitor etoposide: a study of DNA damage, cell cycle regulation and death pathways.

Saleh EM, El-awady RA, Eissa NA, Abdel-Rahman WM.

Cancer Biol Ther. 2012 Sep;13(11):1058-71. doi: 10.4161/cbt.21078. Epub 2012 Aug 16.

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Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial.

Sabzghabaee AM, Dianatkhah M, Sarrafzadegan N, Asgary S, Ghannadi A.

Med Arch. 2012;66(3):198-200.

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Protective effect of treatment with black cumin oil on spatial cognitive functions of rats that suffered global cerebrovascular hypoperfusion.

Azzubaidi MS, Saxena AK, Talib NA, Ahmed QU, Dogarai BB.

Acta Neurobiol Exp (Wars). 2012;72(2):154-65.

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Oral Nigella sativa oil ameliorates ovalbumin-induced bronchial asthma in mice.

Balaha MF, Tanaka H, Yamashita H, Abdel Rahman MN, Inagaki N.

Int Immunopharmacol. 2012 Oct;14(2):224-31. doi: 10.1016/j.intimp.2012.06.023. Epub 2012 Jul 15.

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Nigella sativa as a potential therapy for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats.

Bayir Y, Albayrak A, Can I, Karagoz Y, Cakir A, Suleyman H, Uyanik H, Yayla N, Polat B, Karakus E, Keles MS.

Cell Mol Biol (Noisy-le-grand). 2012 Jun 15;58 Suppl:OL1680-7.

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Nigella sativa (black cumin) seed extract alleviates symptoms of allergic diarrhea in mice, involving opioid receptors.

Duncker SC, Philippe D, Martin-Paschoud C, Moser M, Mercenier A, Nutten S.

PLoS One. 2012;7(6):e39841. doi: 10.1371/journal.pone.0039841. Epub 2012 Jun 29.

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Can methanolic extract of Nigella sativa seed affect glyco-regulatory enzymes in experimental hepatocellular carcinoma?

Abdel-Hamid NM, Abdel-Ghany MI, Nazmy MH, Amgad SW.

Environ Health Prev Med. 2013 Jan;18(1):49-56. doi: 10.1007/s12199-012-0292-8. Epub 2012 Jul 6.

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Biosynthesis of controllable size and shape gold nanoparticles by black seed (Nigella sativa) extract.

Fragoon A, Li J, Zhu J, Zhao J.

J Nanosci Nanotechnol. 2012 Mar;12(3):2337-45.

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Protective effect of Nigella sativa and thymoquinone on serum/glucose deprivation-induced DNA damage in PC12 cells.

Babazadeh B, Sadeghnia HR, Safarpour Kapurchal E, Parsaee H, Nasri S, Tayarani-Najaran Z.

Avicenna J Phytomed. 2012 Summer;2(3):125-32.

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Anti-cancer effects of thymoquinone in mouse neuroblastoma (Neuro-2a) cells through caspase-3 activation with down-regulation of XIAP.

Paramasivam A, Sambantham S, Shabnam J, Raghunandhakumar S, Anandan B, Rajiv R, Vijayashree Priyadharsini J, Jayaraman G.

Toxicol Lett. 2012 Sep 3;213(2):151-9. doi: 10.1016/j.toxlet.2012.06.011. Epub 2012 Jun 23.

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Renal function and arterial blood pressure alterations after exposure to acetaminophen with a potential role of Nigella sativa oil in adult male rats.

Ahmed OG, El-Mottaleb NA.

J Physiol Biochem. 2013 Mar;69(1):1-13. doi: 10.1007/s13105-012-0182-y. Epub 2012 Jun 23.

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Application of non-linear models to predict inhibition effects of various plant hydrosols on Listeria monocytogenes inoculated on fresh-cut apples.

Ozturk I, Tornuk F, Sagdic O, Kisi O.

Foodborne Pathog Dis. 2012 Jul;9(7):607-16. doi: 10.1089/fpd.2012.1138. Epub 2012 Jun 12.

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Bioavailability enhancement studies of amoxicillin with Nigella.

Ali B, Amin S, Ahmad J, Ali A; Mohd Ali, Mir SR.

Indian J Med Res. 2012 Apr;135(4):555-9.

696.

Protective Effects of Nigella sativa Oil in Hyperoxia-Induced Lung Injury.

Tayman C, Cekmez F, Kafa IM, Canpolat FE, Cetinkaya M, Tonbul A, Uysal S, Tunc T, Sarici SU.

Arch Bronconeumol. 2013 Jan;49(1):15-21. doi: 10.1016/j.arbres.2012.03.013. Epub 2012 May 15. English, Spanish.

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Evaluation of the antiepileptic effect of curcumin and Nigella sativa oil in the pilocarpine model of epilepsy in comparison with valproate.

Noor NA, Aboul Ezz HS, Faraag AR, Khadrawy YA.

Epilepsy Behav. 2012 Jun;24(2):199-206. doi: 10.1016/j.yebeh.2012.03.026. Epub 2012 May 8.

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Beneficial effects of Nigella sativa oil on intestinal damage in necrotizing enterocolitis.

Tayman C, Cekmez F, Kafa IM, Canpolat FE, Cetinkaya M, Uysal S, Tunc T, Sarıcı SU.

J Invest Surg. 2012 Oct;25(5):286-94. Epub 2012 May 9.

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Thymoquinone, the Nigella sativa bioactive compound, prevents circulatory oxidative stress caused by 1,2-dimethylhydrazine in erythrocyte during colon postinitiation carcinogenesis.

Harzallah HJ, Grayaa R, Kharoubi W, Maaloul A, Hammami M, Mahjoub T.

Oxid Med Cell Longev. 2012;2012:854065. doi: 10.1155/2012/854065. Epub 2012 Apr 18.

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Cadmium-induced hepatotoxicity and its abrogation by thymoquinone.

Zafeer MF, Waseem M, Chaudhary S, Parvez S.

J Biochem Mol Toxicol. 2012 May;26(5):199-205. doi: 10.1002/jbt.21402. Epub 2012 Apr 26.

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Thymoquinone improves aging-related endothelial dysfunction in the rat mesenteric artery.

Idris-Khodja N, Schini-Kerth V.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul;385(7):749-58. doi: 10.1007/s00210-012-0749-8. Epub 2012 Apr 12.

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Volatile compounds of black cumin seeds (Nigella sativa L.) from microwave-heating and conventional roasting.

Kiralan M.

J Food Sci. 2012 Apr;77(4):C481-4. doi: 10.1111/j.1750-3841.2012.02638.x.

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[Bullous drug eruption with Nigella sativa oil].

Gelot P, Bara-Passot C, Gimenez-Arnau E, Beneton N, Maillard H, Celerier P.

Ann Dermatol Venereol. 2012 Apr;139(4):287-91. doi: 10.1016/j.annder.2012.01.025. Epub 2012 Mar 23. French.

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Mitigation of obesity-promoted diseases by Nigella sativa and thymoquinone.

Vanamala J, Kester AC, Heuberger AL, Reddivari L.

Plant Foods Hum Nutr. 2012 Jun;67(2):111-9. doi: 10.1007/s11130-012-0279-z. Review.

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Thymoquinone prevents and ameliorates dextran sulfate sodium-induced colitis in mice.

Lei X, Liu M, Yang Z, Ji M, Guo X, Dong W.

Dig Dis Sci. 2012 Sep;57(9):2296-303. doi: 10.1007/s10620-012-2156-x. Epub 2012 Apr 3.

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Characterization of thymoquinone binding to human α₁-acid glycoprotein.

Lupidi G, Camaioni E, Khalifé H, Avenali L, Damiani E, Tanfani F, Scirè A.

J Pharm Sci. 2012 Jul;101(7):2564-73. doi: 10.1002/jps.23138. Epub 2012 Mar 29.

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Modulation of the oxidative stress and inflammatory cytokine response by thymoquinone in the collagen induced arthritis in Wistar rats.

Umar S, Zargan J, Umar K, Ahmad S, Katiyar CK, Khan HA.

Chem Biol Interact. 2012 Apr 15;197(1):40-6. doi: 10.1016/j.cbi.2012.03.003. Epub 2012 Mar 19.

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Nigella sativa reduces tissue damage in rat ovaries subjected to torsion and detorsion: oxidative stress, proinflammatory response and histopathological evaluation.

Bayir Y, Karagoz Y, Karakus E, Albayrak A, Sengul O, Can I, Yayla N, Kuskun U, Keles MS.

Gynecol Obstet Invest. 2012;74(1):41-9. doi: 10.1159/000336295. Epub 2012 Mar 21.

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The chemical composition and the content of volatile oil: potential factors that can contribute to the oxidative stability of Nigella sativa L. crude oil.

Edris AE.

J Diet Suppl. 2011 Mar;8(1):34-42. doi: 10.3109/19390211.2010.547242. Epub 2011 Jan 19.

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Comparison of the results of response surface methodology and artificial neural network for the biosorption of lead using black cumin.

Bingöl D, Hercan M, Elevli S, Kiliç E.

Bioresour Technol. 2012 May;112:111-5. doi: 10.1016/j.biortech.2012.02.084. Epub 2012 Feb 24.

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Effect of thymoquinone on cytosolic pH and Na+/H+ exchanger activity in mouse dendritic cells.

Yang W, Bhandaru M, Pasham V, Bobbala D, Zelenak C, Jilani K, Rotte A, Lang F.

Cell Physiol Biochem. 2012;29(1-2):21-30. doi: 10.1159/000337583. Epub 2012 Mar 1.

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Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury.

Ulu R, Dogukan A, Tuzcu M, Gencoglu H, Ulas M, Ilhan N, Muqbil I, Mohammad RM, Kucuk O, Sahin K.

Food Chem Toxicol. 2012 May;50(5):1675-9. doi: 10.1016/j.fct.2012.02.082. Epub 2012 Mar 3.

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Effect of alcoholic extract of Nigella sativa on cisplatin-induced toxicity in rat.

Hadjzadeh MA, Keshavarzi Z, Tabatabaee Yazdi SA, Ghasem Shirazi M, Rajaei Z, Khajavi Rad A.

Iran J Kidney Dis. 2012 Mar;6(2):99-104.

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Ameliorating effects of two extracts of Nigella sativa in middle cerebral artery occluded rat.

Akhtar M, Maikiyo AM, Khanam R, Mujeeb M, Aqil M, Najmi AK.

J Pharm Bioallied Sci. 2012 Jan;4(1):70-5. doi: 10.4103/0975-7406.92740.

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Effects of Nigella sativa and albendazole alone and in combination in Toxocara canis infected mice.

Musa D, Senocak G, Borazan G, Altas M, Ozgonul A, Sogut O, Güldür ME.

J Pak Med Assoc. 2011 Sep;61(9):866-70.

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Characterization of secondary volatile profiles in Nigella sativa seeds from two different origins using accelerated solvent extraction and gas chromatography-mass spectrometry.

Liu X, Abd El-Aty AM, Cho SK, Yang A, Park JH, Shim JH.

Biomed Chromatogr. 2012 Oct;26(10):1157-62. doi: 10.1002/bmc.2671. Epub 2012 Jan 30.

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Effect of thymoquinone, a constituent of Nigella sativa L., on ischemia-reperfusion in rat skeletal muscle.

Hosseinzadeh H, Taiari S, Nassiri-Asl M.

Naunyn Schmiedebergs Arch Pharmacol. 2012 May;385(5):503-8. doi: 10.1007/s00210-012-0726-2. Epub 2012 Jan 22.

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The preventive effect of N-butanol fraction of Nigella sativa on ethylene glycol-induced kidney calculi in rats.

Hadjzadeh MA, Rad AK, Rajaei Z, Tehranipour M, Monavar N.

Pharmacogn Mag. 2011 Oct;7(28):338-43. doi: 10.4103/0973-1296.90416.

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Detection of the antibacterial effect of Nigella sativa ground seeds with water.

Bakathir HA, Abbas NA.

Afr J Tradit Complement Altern Med. 2011;8(2):159-64. Epub 2010 Dec 30.

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Impact of protein binding on the analytical detectability and anticancer activity of thymoquinone.

El-Najjar N, Ketola RA, Nissilä T, Mauriala T, Antopolsky M, Jänis J, Gali-Muhtasib H, Urtti A, Vuorela H.

J Chem Biol. 2011 Jul;4(3):97-107. doi: 10.1007/s12154-010-0052-4. Epub 2011 Jan 8.

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Restoration of renal hemodynamics and functions during black cumin (Nigella sativa) administration in streptozotocin-induced diabetic rats.

Yusuksawad M, Chaiyabutr N.

J Exp Pharmacol. 2011 Dec 22;4:1-7. doi: 10.2147/JEP.S26054. eCollection 2012.

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Thymoquinone inhibits growth and augments 5-fluorouracil-induced apoptosis in gastric cancer cells both in vitro and in vivo.

Lei X, Lv X, Liu M, Yang Z, Ji M, Guo X, Dong W.

Biochem Biophys Res Commun. 2012 Jan 13;417(2):864-8. doi: 10.1016/j.bbrc.2011.12.063. Epub 2011 Dec 20.

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Ayurvedic formulation of Liv-Pro-08 reduces nonalcoholic fatty liver disease in rats fed with high-fat diet.

Suriyavathana Vedanarayanan M, Krishnan N.

J Acupunct Meridian Stud. 2011 Dec;4(4):236-41. doi: 10.1016/j.jams.2011.09.014. Epub 2011 Oct 18.

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Supplementation of Nigella sativa fixed and essential oil mediates potassium bromate induced oxidative stress and multiple organ toxicity.

Sultan MT, Butt MS, Ahmad RS, Pasha I, Ahmad AN, Qayyum MM.

Pak J Pharm Sci. 2012 Jan;25(1):175-81.

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The histopathological effect of thymoquinone on experimentally induced rhinosinusitis in rats.

Cingi C, Eskiizmir G, Burukoğlu D, Erdoğmuş N, Ural A, Ünlü H.

Am J Rhinol Allergy. 2011 Nov-Dec;25(6):e268-72. doi: 10.2500/ajra.2011.25.3703.

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Thymoquinone reduces migration and invasion of human glioblastoma cells associated with FAK, MMP-2 and MMP-9 down-regulation.

Kolli-Bouhafs K, Boukhari A, Abusnina A, Velot E, Gies JP, Lugnier C, Rondé P.

Invest New Drugs. 2012 Dec;30(6):2121-31. doi: 10.1007/s10637-011-9777-3. Epub 2011 Dec 15.

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Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study.

Gheita TA, Kenawy SA.

Phytother Res. 2012 Aug;26(8):1246-8. doi: 10.1002/ptr.3679. Epub 2011 Dec 12.

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Primary human monocyte differentiation regulated by Nigella sativa pressed oil.

Mat MC, Mohamed AS, Hamid SS.

Lipids Health Dis. 2011 Nov 21;10:216. doi: 10.1186/1476-511X-10-216.

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Anticancer activity of Nigella sativa (black seed) — a review.

Randhawa MA, Alghamdi MS.

Am J Chin Med. 2011;39(6):1075-91. Review.

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Black cumin seeds, Artemisia leaves (Artemisia sieberi), and Camellia L. plant extract as phytogenic products in broiler diets and their effects on performance, blood constituents, immunity, and cecal microbial population.

Khalaji S, Zaghari M, Hatami K, Hedari-Dastjerdi S, Lotfi L, Nazarian H.

Poult Sci. 2011 Nov;90(11):2500-10. doi: 10.3382/ps.2011-01393. Erratum in: Poult Sci. 2012 Jan;91(1):271. Hatami, K H [corrected to Hatami, K].

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[Anti-metastasis effect of thymoquinone on human pancreatic cancer].

Wu ZH, Chen Z, Shen Y, Huang LL, Jiang P.

Yao Xue Xue Bao. 2011 Aug;46(8):910-4. Chinese.

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Thymoquinone: potential cure for inflammatory disorders and cancer.

Woo CC, Kumar AP, Sethi G, Tan KH.

Biochem Pharmacol. 2012 Feb 15;83(4):443-51. doi: 10.1016/j.bcp.2011.09.029. Epub 2011 Oct 10. Review.

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Upregulation of chemoprotective enzymes and glutathione by Nigella sativa (black seed) and thymoquinone in CCl4-intoxicated rats.

El-Sayed WM.

Int J Toxicol. 2011 Dec;30(6):707-14. doi: 10.1177/1091581811420741. Epub 2011 Oct 12.

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Immunomodulatory effects of black seeds and garlic on alloxan-induced Diabetes in albino rat.

Abel-Salam BK.

Allergol Immunopathol (Madr). 2012 Nov-Dec;40(6):336-40. doi: 10.1016/j.aller.2011.07.002. Epub 2011 Oct 5.

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Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.

Badr G, Lefevre EA, Mohany M.

PLoS One. 2011;6(9):e23741. doi: 10.1371/journal.pone.0023741. Epub 2011 Sep 1.

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Inhibition of the formation of advanced glycation end products by thymoquinone.

Losso JN, Bawadi HA, Chintalapati M.

Food Chem. 2011 Sep 1;128(1):55-61. doi: 10.1016/j.foodchem.2011.02.076. Epub 2011 Feb 24.

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Inhibition of aflatoxin production and growth of Aspergillus parasiticus by Cuminum cyminum, Ziziphora clinopodioides, and Nigella sativa essential oils.

Khosravi AR, Shokri H, Minooeianhaghighi M.

Foodborne Pathog Dis. 2011 Dec;8(12):1275-80. doi: 10.1089/fpd.2011.0929. Epub 2011 Aug 23.

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Protective effect of Nigella sativa oil against tramadol-induced tolerance and dependence in mice: role of nitric oxide and oxidative stress.

Abdel-Zaher AO, Abdel-Rahman MS, Elwasei FM.

Neurotoxicology. 2011 Dec;32(6):725-33. doi: 10.1016/j.neuro.2011.08.001. Epub 2011 Aug 9.

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The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs.

Boskabady MH, Vahedi N, Amery S, Khakzad MR.

J Ethnopharmacol. 2011 Sep 2;137(2):1028-34. doi: 10.1016/j.jep.2011.07.030. Epub 2011 Jul 27.

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Lindane-induced biochemical perturbations in rat serum and attenuation by omega-3 and Nigella sativa seed oil.

Attia AM, El-Banna SG, Nomeir FR, Abd El-Basser MI.

Indian J Biochem Biophys. 2011 Jun;48(3):184-90.

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Antiatherogenic Potential of Nigella sativa Seeds and Oil in Diet-Induced Hypercholesterolemia in Rabbits.

Al-Naqeep G, Al-Zubairi AS, Ismail M, Amom ZH, Esa NM.

Evid Based Complement Alternat Med. 2011;2011:213628. doi: 10.1093/ecam/neq071. Epub 2011 Jun 16.

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The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs.

Boskabady MH, Keyhanmanesh R, Khamneh S, Ebrahimi MA.

Clinics (Sao Paulo). 2011;66(5):879-87.

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Screening for estrogenic and antiestrogenic activities of plants growing in Egypt and Thailand.

El-Halawany AM, El Dine RS, Chung MH, Nishihara T, Hattori M.

Pharmacognosy Res. 2011 Apr;3(2):107-13. doi: 10.4103/0974-8490.81958.

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Various extraction and analytical techniques for isolation and identification of secondary metabolites from Nigella sativa seeds.

Liu X, Abd El-Aty AM, Shim JH.

Mini Rev Med Chem. 2011 Oct;11(11):947-55. Review.

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The neuroprotective effect of curcumin and Nigella sativa oil against oxidative stress in the pilocarpine model of epilepsy: a comparison with valproate.

Ezz HS, Khadrawy YA, Noor NA.

Neurochem Res. 2011 Nov;36(11):2195-204. doi: 10.1007/s11064-011-0544-9. Epub 2011 Jul 13.

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Effect of thymoquinone on hepatorenal dysfunction and alteration of CYP3A1 and spermidine/spermine N-1-acetyl-transferase gene expression induced by renal ischaemia-reperfusion in rats.

Awad AS, Kamel R, Sherief MA.

J Pharm Pharmacol. 2011 Aug;63(8):1037-42. doi: 10.1111/j.2042-7158.2011.01303.x. Epub 2011 Jun 8.

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Prophylactic effect of green tea and Nigella sativa extracts against fenitrothion-induced toxicity in rat parotid gland.

Korany NS, Ezzat BA.

Arch Oral Biol. 2011 Nov;56(11):1339-46. doi: 10.1016/j.archoralbio.2011.05.006. Epub 2011 Jun 21.

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Anticancer activity of thymoquinone in breast cancer cells: possible involvement of PPAR-γ pathway.

Woo CC, Loo SY, Gee V, Yap CW, Sethi G, Kumar AP, Tan KH.

Biochem Pharmacol. 2011 Sep 1;82(5):464-75. doi: 10.1016/j.bcp.2011.05.030. Epub 2011 Jun 14.

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Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus.

Bamosa AO, Kaatabi H, Lebdaa FM, Elq AM, Al-Sultanb A.

Indian J Physiol Pharmacol. 2010 Oct-Dec;54(4):344-54.

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Thymoquinone from Nigella sativa was more potent than cisplatin in eliminating of SiHa cells via apoptosis with down-regulation of Bcl-2 protein.

Ng WK, Yazan LS, Ismail M.

Toxicol In Vitro. 2011 Oct;25(7):1392-8. doi: 10.1016/j.tiv.2011.04.030. Epub 2011 May 15.

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Ameliorative effect of thymoquinone on ovalbumin-induced allergic conjunctivitis in Balb/c mice.

Hayat K, Asim MB, Nawaz M, Li M, Zhang L, Sun N.

Curr Eye Res. 2011 Jul;36(7):591-8. doi: 10.3109/02713683.2011.573898. Epub 2011 May 23.

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21604966
761.

The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content.

Benhaddou-Andaloussi A, Martineau L, Vuong T, Meddah B, Madiraju P, Settaf A, Haddad PS.

Evid Based Complement Alternat Med. 2011;2011:538671. doi: 10.1155/2011/538671. Epub 2011 Apr 14.

762.

Radiosensitization in human breast carcinoma cells by thymoquinone: role of cell cycle and apoptosis.

Velho-Pereira R, Kumar A, Pandey BN, Jagtap AG, Mishra KP.

Cell Biol Int. 2011 Oct;35(10):1025-9. doi: 10.1042/CBI20100701.

PMID:
21557727
763.

Characterization of butter spoiling yeasts and their inhibition by some spices.

Sagdic O, Ozturk I, Bayram O, Kesmen Z, Yilmaz MT.

J Food Sci. 2010 Nov-Dec;75(9):M597-603. doi: 10.1111/j.1750-3841.2010.01871.x.

PMID:
21535616
764.

Systemic allergic contact dermatitis to black cumin essential oil expressing as generalized erythema multiforme.

Nosbaum A, Ben Said B, Halpern SJ, Nicolas JF, Bérard F.

Eur J Dermatol. 2011 May-Jun;21(3):447-8. doi: 10.1684/ejd.2011.1351. No abstract available.

PMID:
21524993
765.

Contrasting actions of diesel exhaust particles on the pulmonary and cardiovascular systems and the effects of thymoquinone.

Nemmar A, Al-Salam S, Zia S, Marzouqi F, Al-Dhaheri A, Subramaniyan D, Dhanasekaran S, Yasin J, Ali BH, Kazzam EE.

Br J Pharmacol. 2011 Dec;164(7):1871-82. doi: 10.1111/j.1476-5381.2011.01442.x.

766.

Nigella sativa seed extract and its bioactive compound thymoquinone: the new melanogens causing hyperpigmentation in the wall lizard melanophores.

Ali SA, Meitei KV.

J Pharm Pharmacol. 2011 May;63(5):741-6. doi: 10.1111/j.2042-7158.2011.01271.x. Epub 2011 Mar 29.

PMID:
21492177
767.

Antibacterial activity of Thymoquinone, an active principle of Nigella sativa and its potency to prevent bacterial biofilm formation.

Chaieb K, Kouidhi B, Jrah H, Mahdouani K, Bakhrouf A.

BMC Complement Altern Med. 2011 Apr 13;11:29. doi: 10.1186/1472-6882-11-29.

768.

Efficacy of Nigella sativa in alleviating benzo[a]pyrene-induced immunotoxicity in broilers.

Latif IK, Karim AJ, Zuki AB, Zamri-Saad M, Niu JP, Noordin MM.

Histol Histopathol. 2011 Jun;26(6):699-710. doi: 10.14670/HH-26.699.

PMID:
21472685
769.

Treatment of Nigella sativa in experimental sepsis model in rats.

Alici O, Kavakli HS, Koca C, Altintas ND.

Pak J Pharm Sci. 2011 Apr;24(2):227-31.

PMID:
21454175
770.

In vitro antituberculous activity of thymoquinone, an active principle of Nigella sativa.

Randhawa MA.

J Ayub Med Coll Abbottabad. 2011 Apr-Jun;23(2):78-81.

PMID:
24800349
771.

Nigella sativa extract as a potent antioxidant for petrochemical-induced oxidative stress.

Ashraf SS, Rao MV, Kaneez FS, Qadri S, Al-Marzouqi AH, Chandranath IS, Adem A.

J Chromatogr Sci. 2011 Apr;49(4):321-6.

PMID:
21439125
772.

Determination of oxygen radical absorbance capacity of black cumin (Nigella sativa) seed quinone compounds.

Tesarova H, Svobodova B, Kokoska L, Marsik P, Pribylova M, Landa P, Vadlejch J.

Nat Prod Commun. 2011 Feb;6(2):213-6.

PMID:
21425677
773.

Comparative gastroprotective effects of natural honey, Nigella sativa and cimetidine against acetylsalicylic acid induced gastric ulcer in albino rats.

Bukhari MH, Khalil J, Qamar S, Qamar Z, Zahid M, Ansari N, Bakhshi IM.

J Coll Physicians Surg Pak. 2011 Mar;21(3):151-6. doi: 03.2011/JCPSP.151156.

PMID:
21419021
774.

Efficacy and safety of a multiherbal formula with vitamin C and zinc (Immumax) in the management of the common cold.

Yakoot M, Salem A.

Int J Gen Med. 2011 Jan 12;4:45-51. doi: 10.2147/IJGM.S16266.

775.

Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs.

Boskabady MH, Keyhanmanesh R, Khameneh S, Doostdar Y, Khakzad MR.

J Zhejiang Univ Sci B. 2011 Mar;12(3):201-9. doi: 10.1631/jzus.B1000163.

776.

Investigation of lipids profiles of Nigella, lupin and artichoke seed oils to be used as healthy oils.

M Hassanein MM, El-Shami SM, El-Mallah MH.

J Oleo Sci. 2011;60(3):99-107.

777.

Validated high-performance thin-layer chromatographic method for the quantification of thymoquinone in Nigella Sativa extracts and formulations.

Velho-Pereira RM, Barhate CR, Kulkarni SR, Jagtap AG.

Phytochem Anal. 2011 Jul-Aug;22(4):367-73. doi: 10.1002/pca.1289. Epub 2011 Feb 19.

PMID:
21337651
778.

«Blockade of nitric oxide overproduction and oxidative stress by Nigella sativa oil attenuates morphine-induced tolerance» by Abdel-Zaher et al.

Mauro D, Procopio L.

Neurochem Res. 2011 May;36(5):924-5. doi: 10.1007/s11064-011-0421-6. Epub 2011 Feb 18. No abstract available.

PMID:
21331793
779.
780.

Phytochemical and biological investigation of the extracts of Nigella sativa L. seed waste.

Michel CG, El-Sayed NS, Moustafa SF, Ezzat SM, Nesseem DI, El-Alfy TS.

Drug Test Anal. 2011 Apr;3(4):245-54. doi: 10.1002/dta.225. Epub 2011 Feb 9.

PMID:
21309000
781.

In vitro antifungal effect of black cumin seed quinones against dairy spoilage yeasts at different acidity levels.

Halamova K, Kokoska L, Flesar J, Sklenickova O, Svobodova B, Marsik P.

J Food Prot. 2010 Dec;73(12):2291-5.

PMID:
21219751
782.

Thymoquinone suppresses growth and induces apoptosis via generation of reactive oxygen species in primary effusion lymphoma.

Hussain AR, Ahmed M, Ahmed S, Manogaran P, Platanias LC, Alvi SN, Al-Kuraya KS, Uddin S.

Free Radic Biol Med. 2011 Apr 15;50(8):978-87. doi: 10.1016/j.freeradbiomed.2010.12.034. Epub 2011 Jan 4.

PMID:
21215312
783.

The potential inhibitory effect of cuminum cyminum, ziziphora clinopodioides and nigella sativaessential oils on the growth of Aspergillus fumigatus and Aspergillus.

Khosravi AR, Minooeianhaghighi MH, Shokri H, Emami SA, S M A, Asili J.

Braz J Microbiol. 2011 Jan;42(1):216-24. doi: 10.1590/S1517-838220110001000027.

784.

Anticancer activities of Nigella sativa (black cumin).

Khan MA, Chen HC, Tania M, Zhang DZ.

Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):226-32. doi: 10.4314/ajtcam.v8i5S.10. Epub 2011 Jul 3. Review.

785.
786.

Protective effect of pretreatment with thymoquinone against Aflatoxin B(1) induced liver toxicity in mice.

Nili-Ahmadabadi A, Tavakoli F, Hasanzadeh G, Rahimi H, Sabzevari O.

Daru. 2011;19(4):282-7.

787.

Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis.

Okeola VO, Adaramoye OA, Nneji CM, Falade CO, Farombi EO, Ademowo OG.

Parasitol Res. 2011 Jun;108(6):1507-12. doi: 10.1007/s00436-010-2204-4. Epub 2010 Dec 14.

PMID:
21153838
788.

Antineoplastic effects of bee honey and Nigella sativa on hepatocellular carcinoma cells.

Hassan MI, Mabrouk GM, Shehata HH, Aboelhussein MM.

Integr Cancer Ther. 2012 Dec;11(4):354-63. doi: 10.1177/1534735410387422. Epub 2010 Dec 8.

PMID:
21147814
789.

The protective effect of thymoquinone against sepsis syndrome morbidity and mortality in mice.

Alkharfy KM, Al-Daghri NM, Al-Attas OS, Alokail MS.

Int Immunopharmacol. 2011 Feb;11(2):250-4. doi: 10.1016/j.intimp.2010.11.032. Epub 2010 Dec 9.

PMID:
21145996
790.

Novel antifungal defensins from Nigella sativa L. seeds.

Rogozhin EA, Oshchepkova YI, Odintsova TI, Khadeeva NV, Veshkurova ON, Egorov TA, Grishin EV, Salikhov SI.

Plant Physiol Biochem. 2011 Feb;49(2):131-7. doi: 10.1016/j.plaphy.2010.10.008. Epub 2010 Nov 18.

PMID:
21144761
791.

Thymoquinone inhibits matrix metalloproteinase expression in rabbit chondrocytes and cartilage in experimental osteoarthritis.

Chen WP, Tang JL, Bao JP, Wu LD.

Exp Biol Med (Maywood). 2010 Dec;235(12):1425-31. doi: 10.1258/ebm.2010.010174.

PMID:
21127340
792.

Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide.

Tiruppur Venkatachallam SK, Pattekhan H, Divakar S, Kadimi US.

J Food Sci Technol. 2010 Dec;47(6):598-605. doi: 10.1007/s13197-010-0109-y. Epub 2010 Nov 1.

793.

The effect of thymoquinone on intractable pediatric seizures (pilot study).

Akhondian J, Kianifar H, Raoofziaee M, Moayedpour A, Toosi MB, Khajedaluee M.

Epilepsy Res. 2011 Jan;93(1):39-43. doi: 10.1016/j.eplepsyres.2010.10.010. Epub 2010 Nov 26.

PMID:
21112742
794.

Effect of thymoquinone on the lung pathology and cytokine levels of ovalbumin-sensitized guinea pigs.

Keyhanmanesh R, Boskabady MH, Khamneh S, Doostar Y.

Pharmacol Rep. 2010 Sep-Oct;62(5):910-6.

795.

The effects of Nigella sativa against oxidative injury in a rat model of subarachnoid hemorrhage.

Erşahin M, Toklu HZ, Akakin D, Yuksel M, Yeğen BC, Sener G.

Acta Neurochir (Wien). 2011 Feb;153(2):333-41. doi: 10.1007/s00701-010-0853-9. Epub 2010 Nov 12.

PMID:
21072672
796.

Fatty acids, essential oil, and phenolics modifications of black cumin fruit under NaCl stress conditions.

Bourgou S, Bettaieb I, Saidani M, Marzouk B.

J Agric Food Chem. 2010 Dec 8;58(23):12399-406. doi: 10.1021/jf103415q. Epub 2010 Nov 4.

PMID:
21049998
797.

Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin.

El-Beshbishy HA, Mohamadin AM, Nagy AA, Abdel-Naim AB.

Indian J Exp Biol. 2010 Mar;48(3):280-8.

PMID:
21046982
798.

Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells.

Arafa el-SA, Zhu Q, Shah ZI, Wani G, Barakat BM, Racoma I, El-Mahdy MA, Wani AA.

Mutat Res. 2011 Jan 10;706(1-2):28-35. doi: 10.1016/j.mrfmmm.2010.10.007. Epub 2010 Oct 30.

799.

Thymoquinone attenuates diethylnitrosamine induction of hepatic carcinogenesis through antioxidant signaling.

Sayed-Ahmed MM, Aleisa AM, Al-Rejaie SS, Al-Yahya AA, Al-Shabanah OA, Hafez MM, Nagi MN.

Oxid Med Cell Longev. 2010 Jul-Aug;3(4):254-61. doi: 10.4161/oxim.3.4.12714.

800.

Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats.

Nagi MN, Al-Shabanah OA, Hafez MM, Sayed-Ahmed MM.

J Biochem Mol Toxicol. 2011 May-Jun;25(3):135-42. doi: 10.1002/jbt.20369. Epub 2010 Oct 18.

PMID:
20957680

801 to 1000 of 1126

 

801.

Herbal treatment of allergic rhinitis: the use of Nigella sativa.

Nikakhlagh S, Rahim F, Aryani FH, Syahpoush A, Brougerdnya MG, Saki N.

Am J Otolaryngol. 2011 Sep-Oct;32(5):402-7. doi: 10.1016/j.amjoto.2010.07.019. Epub 2010 Oct 13.

PMID:
20947211
802.

Review on molecular and therapeutic potential of thymoquinone in cancer.

Banerjee S, Padhye S, Azmi A, Wang Z, Philip PA, Kucuk O, Sarkar FH, Mohammad RM.

Nutr Cancer. 2010;62(7):938-46. doi: 10.1080/01635581.2010.509832. Review.

803.

Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats.

Abdelmeguid NE, Fakhoury R, Kamal SM, Al Wafai RJ.

J Diabetes. 2010 Dec;2(4):256-66. doi: 10.1111/j.1753-0407.2010.00091.x.

805.

Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis.

Vaillancourt F, Silva P, Shi Q, Fahmi H, Fernandes JC, Benderdour M.

J Cell Biochem. 2011 Jan;112(1):107-17. doi: 10.1002/jcb.22884.

PMID:
20872780
806.

The possible effect of diets containing Nigella sativa and Thymus vulgaris on blood parameters and some organs structure in rabbit.

Tousson E, El-Moghazy M, El-Atrsh E.

Toxicol Ind Health. 2011 Mar;27(2):107-16. doi: 10.1177/0748233710381891. Epub 2010 Sep 7.

PMID:
20823051
807.

Protective effects of thymoquinone against methotrexate-induced testicular injury.

Gökçe A, Oktar S, Koc A, Yonden Z.

Hum Exp Toxicol. 2011 Aug;30(8):897-903. doi: 10.1177/0960327110382564. Epub 2010 Sep 2.

PMID:
20813795
808.

Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.

Abusnina A, Alhosin M, Keravis T, Muller CD, Fuhrmann G, Bronner C, Lugnier C.

Cell Signal. 2011 Jan;23(1):152-60. doi: 10.1016/j.cellsig.2010.08.015. Epub 2010 Aug 31.

PMID:
20807569
810.

Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male.

Datau EA, Wardhana, Surachmanto EE, Pandelaki K, Langi JA, Fias.

Acta Med Indones. 2010 Jul;42(3):130-4.

811.

Total synthesis and anticancer activities of (-)- and (+)-thespesone.

Breyer S, Effenberger-Neidnicht K, Schobert R.

J Org Chem. 2010 Sep 17;75(18):6214-8. doi: 10.1021/jo1012493.

PMID:
20712304
812.

Thymoquinone induces telomere shortening, DNA damage and apoptosis in human glioblastoma cells.

Gurung RL, Lim SN, Khaw AK, Soon JF, Shenoy K, Mohamed Ali S, Jayapal M, Sethu S, Baskar R, Hande MP.

PLoS One. 2010 Aug 12;5(8):e12124. doi: 10.1371/journal.pone.0012124.

813.

Nigella sativa: reduces the risk of various maladies.

Butt MS, Sultan MT.

Crit Rev Food Sci Nutr. 2010 Aug;50(7):654-65. doi: 10.1080/10408390902768797. Review.

PMID:
20694927
814.

Protection against radiation-induced oxidative damage by an ethanolic extract of Nigella sativa L.

Rastogi L, Feroz S, Pandey BN, Jagtap A, Mishra KP.

Int J Radiat Biol. 2010 Sep;86(9):719-31. doi: 10.3109/09553002.2010.484480.

PMID:
20670109
815.

Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats.

Isik F, Tunali Akbay T, Yarat A, Genc Z, Pisiriciler R, Caliskan-Ak E, Cetinel S, Altıntas A, Sener G.

Dig Dis Sci. 2011 Mar;56(3):721-30. doi: 10.1007/s10620-010-1333-z. Epub 2010 Jul 24.

PMID:
20658190
816.

Quantitative analysis and toxicity determination of artifacts originated in a Thai traditional medicine Prasaplai.

Tangyuenyongwatana P, Gritsanapan W.

Pharm Biol. 2010 May;48(5):584-8. doi: 10.3109/13880200903214223.

PMID:
20645803
817.

Analgesic effect of Nigella sativa seeds extract on experimentally induced pain in albino mice.

Bashir MU, Qureshi HJ.

J Coll Physicians Surg Pak. 2010 Jul;20(7):464-7. doi: 04.2010/JCPSP.464467.

PMID:
20642947
818.

Nigella sativa L. seed extract modulates the neurotransmitter amino acids release in cultured neurons in vitro.

El-Naggar T, Gómez-Serranillos MP, Palomino OM, Arce C, Carretero ME.

J Biomed Biotechnol. 2010;2010:398312. doi: 10.1155/2010/398312. Epub 2010 Jun 16.

819.

Comparative study of Nigella Sativa and triple therapy in eradication of Helicobacter Pylori in patients with non-ulcer dyspepsia.

Salem EM, Yar T, Bamosa AO, Al-Quorain A, Yasawy MI, Alsulaiman RM, Randhawa MA.

Saudi J Gastroenterol. 2010 Jul-Sep;16(3):207-14. doi: 10.4103/1319-3767.65201.

820.

Nigella sativa modulates splenocyte proliferation, Th1/Th2 cytokine profile, macrophage function and NK anti-tumor activity.

Majdalawieh AF, Hmaidan R, Carr RI.

J Ethnopharmacol. 2010 Sep 15;131(2):268-75. doi: 10.1016/j.jep.2010.06.030. Epub 2010 Jun 30.

PMID:
20600757
821.

Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo.

Jafri SH, Glass J, Shi R, Zhang S, Prince M, Kleiner-Hancock H.

J Exp Clin Cancer Res. 2010 Jul 1;29:87. doi: 10.1186/1756-9966-29-87.

822.

A study of the chemical composition of black cumin oil and its effect on penetration enhancement from transdermal formulations.

Amin S, Mir SR, Kohli K, Ali B, Ali M.

Nat Prod Res. 2010 Jul;24(12):1151-7. doi: 10.1080/14786410902940909.

PMID:
20582810
823.

Combinatorial effects of thymoquinone on the anti-cancer activity of doxorubicin.

Effenberger-Neidnicht K, Schobert R.

Cancer Chemother Pharmacol. 2011 Apr;67(4):867-74. doi: 10.1007/s00280-010-1386-x. Epub 2010 Jun 26.

PMID:
20582416
824.

Blockade of nitric oxide overproduction and oxidative stress by Nigella sativa oil attenuates morphine-induced tolerance and dependence in mice.

Abdel-Zaher AO, Abdel-Rahman MS, ELwasei FM.

Neurochem Res. 2010 Oct;35(10):1557-65. doi: 10.1007/s11064-010-0215-2. Epub 2010 Jun 15.

PMID:
20552271
825.

Antiplasmodial Activity of Some Medicinal Plants Used in Sudanese Folk-medicine.

Ahmed el-HM, Nour BY, Mohammed YG, Khalid HS.

Environ Health Insights. 2010 Feb 4;4:1-6.

826.

Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species.

Koka PS, Mondal D, Schultz M, Abdel-Mageed AB, Agrawal KC.

Exp Biol Med (Maywood). 2010 Jun;235(6):751-60. doi: 10.1258/ebm.2010.009369.

PMID:
20511679
827.

Evaluation of immunomodulatory effect of three herbal plants growing in Egypt.

Ghonime M, Eldomany R, Abdelaziz A, Soliman H.

Immunopharmacol Immunotoxicol. 2011 Mar;33(1):141-5. doi: 10.3109/08923973.2010.487490. Epub 2010 May 27.

PMID:
20507215
828.

The effect of fixed oil and water extracts of Nigella sativa on sickle cells: an in vitro study.

Ibraheem NK, Ahmed JH, Hassan MK.

Singapore Med J. 2010 Mar;51(3):230-4.

829.

Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies.

Torres MP, Ponnusamy MP, Chakraborty S, Smith LM, Das S, Arafat HA, Batra SK.

Mol Cancer Ther. 2010 May;9(5):1419-31. doi: 10.1158/1535-7163.MCT-10-0075. Epub 2010 Apr 27.

830.

Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits.

Nader MA, el-Agamy DS, Suddek GM.

Arch Pharm Res. 2010 Apr;33(4):637-43. doi: 10.1007/s12272-010-0420-1. Epub 2010 Apr 27.

PMID:
20422375
831.

Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer.

Banerjee S, Azmi AS, Padhye S, Singh MW, Baruah JB, Philip PA, Sarkar FH, Mohammad RM.

Pharm Res. 2010 Jun;27(6):1146-58. doi: 10.1007/s11095-010-0145-3. Epub 2010 Apr 27.

832.
833.
834.

Potential adjuvant effects of Nigella sativa seeds to improve specific immunotherapy in allergic rhinitis patients.

Işik H, Cevikbaş A, Gürer US, Kiran B, Uresin Y, Rayaman P, Rayaman E, Gürbüz B, Büyüköztürk S.

Med Princ Pract. 2010;19(3):206-11. doi: 10.1159/000285289. Epub 2010 Mar 29.

835.

Protective effects of Nigella sativa on intestinal ischemia-reperfusion injury in rats.

Terzi A, Coban S, Yildiz F, Ates M, Bitiren M, Taskin A, Aksoy N.

J Invest Surg. 2010 Feb;23(1):21-7. doi: 10.3109/08941930903469375.

PMID:
20233001
836.

Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.

Finlay TM, Jayanth P, Amith SR, Gilmour A, Guzzo C, Gee K, Beyaert R, Szewczuk MR.

Glycoconj J. 2010 Apr;27(3):329-48. doi: 10.1007/s10719-010-9281-6. Epub 2010 Mar 6.

PMID:
20213245
837.

[Analysis on chemical components of volatile oil and determination of thymoquinone from seed of Nigella glandulifera].

Geng D, Zhang S, Lan J.

Zhongguo Zhong Yao Za Zhi. 2009 Nov;34(22):2887-90. Chinese.

PMID:
20209952
838.

Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects.

Al-Jenoobi FI, Al-Thukair AA, Abbas FA, Ansari MJ, Alkharfy KM, Al-Mohizea AM, Al-Suwayeh SA, Jamil S.

Drug Metab Lett. 2010 Jan;4(1):51-5.

PMID:
20201775
839.

Thymoquinone, a potential therapeutic agent of Nigella sativa, binds to site I of human serum albumin.

Lupidi G, Scire A, Camaioni E, Khalife KH, De Sanctis G, Tanfani F, Damiani E.

Phytomedicine. 2010 Aug;17(10):714-20. doi: 10.1016/j.phymed.2010.01.011. Epub 2010 Feb 18.

PMID:
20171066
840.

Antiasthmatic effect of Nigella sativa in airways of asthmatic patients.

Boskabady MH, Mohsenpoor N, Takaloo L.

Phytomedicine. 2010 Aug;17(10):707-13. doi: 10.1016/j.phymed.2010.01.002. Epub 2010 Feb 10.

PMID:
20149611
841.

Protective effects of Nigella sativa against ischemia-reperfusion injury of kidneys.

Yildiz F, Coban S, Terzi A, Savas M, Bitiren M, Celik H, Aksoy N.

Ren Fail. 2010 Jan;32(1):126-31. doi: 10.3109/08860220903367577.

PMID:
20113278
842.

Effect of thymoquinone on mouse dendritic cells.

Xuan NT, Shumilina E, Qadri SM, Götz F, Lang F.

Cell Physiol Biochem. 2010;25(2-3):307-14. doi: 10.1159/000276563. Epub 2010 Jan 12.

843.

Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.

Ravindran J, Nair HB, Sung B, Prasad S, Tekmal RR, Aggarwal BB.

Biochem Pharmacol. 2010 Jun 1;79(11):1640-7. doi: 10.1016/j.bcp.2010.01.023. Epub 2010 Jan 25. Retraction in: Biochem Pharmacol. 2016 Feb 15;102:146.

844.

Radioprotective effects of black seed (Nigella sativa) oil against hemopoietic damage and immunosuppression in gamma-irradiated rats.

Assayed ME.

Immunopharmacol Immunotoxicol. 2010 Jun;32(2):284-96. doi: 10.3109/08923970903307552.

PMID:
20105084
845.

Terpene conjugates of the Nigella sativa seed-oil constituent thymoquinone with enhanced efficacy in cancer cells.

Effenberger K, Breyer S, Schobert R.

Chem Biodivers. 2010 Jan;7(1):129-39. doi: 10.1002/cbdv.200900328.

PMID:
20087986
846.

Protective effect of Nigella sativa extract and thymoquinone on serum/glucose deprivation-induced PC12 cells death.

Mousavi SH, Tayarani-Najaran Z, Asghari M, Sadeghnia HR.

Cell Mol Neurobiol. 2010 May;30(4):591-8. doi: 10.1007/s10571-009-9484-1. Epub 2010 Jan 7.

PMID:
20054635
847.

Protective effects of the volatile oil of Nigella sativa seeds on beta-cell damage in streptozotocin-induced diabetic rats: a light and electron microscopic study.

Kanter M, Akpolat M, Aktas C.

J Mol Histol. 2009 Oct;40(5-6):379-85. doi: 10.1007/s10735-009-9251-0. Epub 2010 Jan 5.

PMID:
20049514
848.

Efficacy of Sri Lankan Traditional Decoction of Katuwelbatu Deduru Katukadi in treatment of Kaphaja Shira Shula (Chronic Sinusitis).

Ediriweera ER, Rathnayaka RL, Premakeerthi WM, Weerasinghe KD.

Ayu. 2010 Jan;31(1):58-61. doi: 10.4103/0974-8520.68208.

849.

The effects of Nigella sativa on bile duct ligation induced-liver injury in rats.

Coban S, Yildiz F, Terzi A, Al B, Aksoy N, Bitiren M, Celik H.

Cell Biochem Funct. 2010 Jan;28(1):83-8. doi: 10.1002/cbf.1624.

PMID:
20029957
850.

Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats.

Ismail M, Al-Naqeep G, Chan KW.

Free Radic Biol Med. 2010 Mar 1;48(5):664-72. doi: 10.1016/j.freeradbiomed.2009.12.002. Epub 2009 Dec 11.

PMID:
20005291
851.

Thymoquinone-induced relaxation of isolated rat pulmonary artery.

Suddek GM.

J Ethnopharmacol. 2010 Feb 3;127(2):210-4. doi: 10.1016/j.jep.2009.11.019. Epub 2009 Dec 2.

PMID:
19961917
852.

Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa.

Shafi G, Munshi A, Hasan TN, Alshatwi AA, Jyothy A, Lei DK.

Cancer Cell Int. 2009 Nov 27;9:29. doi: 10.1186/1475-2867-9-29.

853.

Antimicrobial effect of garlic (Allium sativum).

Goncagul G, Ayaz E.

Recent Pat Antiinfect Drug Discov. 2010 Jan;5(1):91-3. Review.

PMID:
19929845
854.

Antimutagenic effects of ethanolic extracts from selected Palestinian medicinal plants.

Khader M, Bresgen N, Eckl PM.

J Ethnopharmacol. 2010 Feb 3;127(2):319-24. doi: 10.1016/j.jep.2009.11.001. Epub 2009 Nov 11.

PMID:
19913082
855.

Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats.

Pari L, Sankaranarayanan C.

Life Sci. 2009 Dec 16;85(23-26):830-4. doi: 10.1016/j.lfs.2009.10.021. Epub 2009 Nov 10.

PMID:
19903489
856.

Regulation of low-density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase gene expression by thymoquinone-rich fraction and thymoquinone in HepG2 cells.

Al-Naqeep G, Ismail M, Allaudin Z.

J Nutrigenet Nutrigenomics. 2009;2(4-5):163-72. doi: 10.1159/000227264. Epub 2009 Oct 30.

PMID:
19887822
857.

Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells.

Benhaddou-Andaloussi A, Martineau LC, Vallerand D, Haddad Y, Afshar A, Settaf A, Haddad PS.

Diabetes Obes Metab. 2010 Feb;12(2):148-57. doi: 10.1111/j.1463-1326.2009.01131.x. Epub 2009 Sep 25.

PMID:
19788435
858.

Cellular transport of anti-inflammatory pro-drugs originated from a herbal formulation of Zingiber cassumunar and Nigella sativa.

Tangyuenyongwatana P, Kowapradit J, Opanasopit P, Gritsanapan W.

Chin Med. 2009 Sep 25;4:19. doi: 10.1186/1749-8546-4-19.

859.

Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells.

Chehl N, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA.

HPB (Oxford). 2009 Aug;11(5):373-81. doi: 10.1111/j.1477-2574.2009.00059.x.

860.

Effect of nigella (Nigella sativa L.) seeds on hematological parameters in rats.

Kocyigit Y, Atamer Y, Uysal E, Baran MS.

Saudi Med J. 2009 Sep;30(9):1233-5. No abstract available.

PMID:
19750275
861.

The protective effect of thymoquinone, an anti-oxidant and anti-inflammatory agent, against renal injury: a review.

Ragheb A, Attia A, Eldin WS, Elbarbry F, Gazarin S, Shoker A.

Saudi J Kidney Dis Transpl. 2009 Sep;20(5):741-52. Review.

862.

The effect of essential oil extracted from Nigella sativa (L.) seeds on human neutrophil functions.

Kacem R, Meraihi Z.

Nat Prod Res. 2009;23(13):1168-75. doi: 10.1080/14786410802228611.

PMID:
19731134
863.

The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs.

Keyhanmanesh R, Boskabady MH, Eslamizadeh MJ, Khamneh S, Ebrahimi MA.

Planta Med. 2010 Feb;76(3):218-22. doi: 10.1055/s-0029-1186054. Epub 2009 Aug 26.

PMID:
19711253
864.

Safety assessment of black cumin fixed and essential oil in normal Sprague Dawley rats: Serological and hematological indices.

Tauseef Sultan M, Butt MS, Anjum FM.

Food Chem Toxicol. 2009 Nov;47(11):2768-75. doi: 10.1016/j.fct.2009.08.011. Epub 2009 Aug 21.

PMID:
19699773
865.

Effects of Nigella sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats.

Hamdy NM, Taha RA.

Pharmacology. 2009;84(3):127-34. doi: 10.1159/000234466. Epub 2009 Aug 13.

PMID:
19684436
866.

[Isolation of the lipid-transporting protein Ns-LTP1 from seeds of the garden fennel flower (Nigella sativa)].

Oshchepkova IuI, Veshkurova ON, Rogozhin EA, Musoliamov AKh, Smirnov AN, Odintsova TI, Egorov TsA, Grishin EV, Salikhov ShI.

Bioorg Khim. 2009 May-Jun;35(3):344-9. Russian.

PMID:
19621049
867.

The effect of dietary supplementation of Nigella sativa L. on serum lipid profile in rats.

Kocyigit Y, Atamer Y, Uysal E.

Saudi Med J. 2009 Jul;30(7):893-6.

PMID:
19618002
868.

Anti bacterial activity of Nigella sativa against clinical isolates of methicillin resistant Staphylococcus aureus.

Hannan A, Saleem S, Chaudhary S, Barkaat M, Arshad MU.

J Ayub Med Coll Abbottabad. 2008 Jul-Sep;20(3):72-4.

PMID:
19610522
869.

Gastroprotective effect of an aqueous suspension of black cumin Nigella sativa on necrotizing agents-induced gastric injury in experimental animals.

Al Mofleh IA, Alhaider AA, Mossa JS, Al-Sohaibani MO, Al-Yahya MA, Rafatullah S, Shaik SA.

Saudi J Gastroenterol. 2008 Jul;14(3):128-34. doi: 10.4103/1319-3767.41731.

870.

Nigella sativa seeds: folklore treatment in modern day medicine.

Tariq M.

Saudi J Gastroenterol. 2008 Jul;14(3):105-6. doi: 10.4103/1319-3767.41725. No abstract available.

871.

Clinical and therapeutic applications of Nigella in the management of tropical infectious disorders besides Schistosomiasis.

Kapoor S.

Rev Inst Med Trop Sao Paulo. 2009 May-Jun;51(3):177. No abstract available.

872.

Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer.

Banerjee S, Kaseb AO, Wang Z, Kong D, Mohammad M, Padhye S, Sarkar FH, Mohammad RM.

Cancer Res. 2009 Jul 1;69(13):5575-83. doi: 10.1158/0008-5472.CAN-08-4235. Epub 2009 Jun 23.

873.

Effects of two-months Nigella sativa supplementation on cardiac hemodynamics and adrenergic responsiveness.

Al-Hariri MT, Yar T, Bamosa AO, El-Bahai MN.

J Pak Med Assoc. 2009 Jun;59(6):363-8.

874.

Ancient nigella seeds from Boyali Höyük in north-central Turkey.

Salih B, Sipahi T, Dönmez EO.

J Ethnopharmacol. 2009 Jul 30;124(3):416-20. doi: 10.1016/j.jep.2009.05.039. Epub 2009 Jun 6.

PMID:
19505557
876.

Evaluation of antimicrobial and anti-inflammatory activities of seed extracts from six Nigellaspecies.

Landa P, Marsik P, Havlik J, Kloucek P, Vanek T, Kokoska L.

J Med Food. 2009 Apr;12(2):408-15. doi: 10.1089/jmf.2007.0600.

PMID:
19459745
877.

Effects of Nigella sativa seed extract on ameliorating lung tissue damage in rats after experimental pulmonary aspirations.

Kanter M.

Acta Histochem. 2009;111(5):393-403. doi: 10.1016/j.acthis.2008.10.008. Epub 2009 May 9.

PMID:
19428057
878.
879.

Protective effects of nigella sativa against gentamicin-induced nephrotoxicity in rats.

Yaman I, Balikci E.

Exp Toxicol Pathol. 2010 Mar;62(2):183-90. doi: 10.1016/j.etp.2009.03.006. Epub 2009 Apr 23.

PMID:
19398313
880.

A new and novel treatment of opioid dependence: Nigella sativa 500 mg.

Sangi S, Ahmed SP, Channa MA, Ashfaq M, Mastoi SM.

J Ayub Med Coll Abbottabad. 2008 Apr-Jun;20(2):118-24.

PMID:
19385474
881.

Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats.

Al-Ali A, Alkhawajah AA, Randhawa MA, Shaikh NA.

J Ayub Med Coll Abbottabad. 2008 Apr-Jun;20(2):25-7.

PMID:
19385451
882.

Black seed, Nigella sativa, deserves more attention.

Randhawa MA.

J Ayub Med Coll Abbottabad. 2008 Apr-Jun;20(2):1-2. No abstract available.

PMID:
19385445
883.

Therapeutic effects of Nigella sativa on chronic HAART-induced hyperinsulinemia in rats.

Chandra S, Murthy SN, Mondal D, Agrawal KC.

Can J Physiol Pharmacol. 2009 Apr;87(4):300-9. doi: 10.1139/Y09-014.

PMID:
19370083
884.

Amelioration of chronic relapsing experimental autoimmune encephalomyelitis (cr-eae) using thymoquinone — biomed 2009.

Mohamed A, Waris HM, Ramadan H, Quereshi M, Kalra J.

Biomed Sci Instrum. 2009;45:274-9.

PMID:
19369775
885.

Repeated administration of Nigella sativa decreases 5-HT turnover and produces anxiolytic effects in rats.

Perveen T, Haider S, Kanwal S, Haleem DJ.

Pak J Pharm Sci. 2009 Apr;22(2):139-44.

PMID:
19339222
886.

HIV-1 protease inhibitor induced oxidative stress in pancreatic beta-cells: protection with thymoquinone.

[No authors listed]

Exp Biol Med (Maywood). 2009 Apr;234(4):x. No abstract available.

PMID:
19332653
887.

Effects of thymoquinone-fatty acid conjugates on cancer cells.

Breyer S, Effenberger K, Schobert R.

ChemMedChem. 2009 May;4(5):761-8. doi: 10.1002/cmdc.200800430.

PMID:
19322799
888.

Methyl jasmonate induced accumulation of kalopanaxsaponin I in Nigella sativa.

Scholz M, Lipinski M, Leupold M, Luftmann H, Harig L, Ofir R, Fischer R, Prüfer D, Müller KJ.

Phytochemistry. 2009 Mar;70(4):517-22. doi: 10.1016/j.phytochem.2009.01.018. Epub 2009 Mar 11.

PMID:
19282005
889.
890.

A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases.

Hasani-Ranjbar S, Larijani B, Abdollahi M.

Inflamm Allergy Drug Targets. 2009 Mar;8(1):2-10. Review.

PMID:
19275687
891.

Relaxant effects of different fractions from Nigella sativa L. on guinea pig tracheal chains and its possible mechanism(s).

Boskabady MH, Keyhanmanesh R, Saadatloo MA.

Indian J Exp Biol. 2008 Dec;46(12):805-10.

PMID:
19245176
892.

Comparison of chemical composition and antibacterial activity of Nigella sativa seed essential oils obtained by different extraction methods.

Kokoska L, Havlik J, Valterova I, Sovova H, Sajfrtova M, Jankovska I.

J Food Prot. 2008 Dec;71(12):2475-80.

PMID:
19244901
893.

HIV-1 protease inhibitor induced oxidative stress suppresses glucose stimulated insulin release: protection with thymoquinone.

Chandra S, Mondal D, Agrawal KC.

Exp Biol Med (Maywood). 2009 Apr;234(4):442-53. doi: 10.3181/0811-RM-317. Epub 2009 Feb 20.

PMID:
19234050
894.

Protection by Nigella sativa against carbon tetrachloride-induced downregulation of hepatic cytochrome P450 isozymes in rats.

Ibrahim ZS, Ishizuka M, Soliman M, ElBohi K, Sobhy W, Muzandu K, Elkattawy AM, Sakamoto KQ, Fujita S.

Jpn J Vet Res. 2008 Nov;56(3):119-28.

PMID:
19177741
895.

New principles from seeds of Nigella sativa.

Mehta BK, Pandit V, Gupta M.

Nat Prod Res. 2009;23(2):138-48. doi: 10.1080/14786410801892078.

PMID:
19173122
896.

Effects of thymoquinone and selenium on the proliferation of mg 63 cells in tissue culture.

Barron J, Benghuzzi H, Tucci M.

Biomed Sci Instrum. 2008;44:434-40.

PMID:
19141954
897.

Effects of Nigella sativa supplementation for one month on cardiac reserve in rats.

Yar T, El-Hariri M, El-Bahai MN, Bamosa AO.

Indian J Physiol Pharmacol. 2008 Apr-Jun;52(2):141-8.

PMID:
19130857
898.

Gastroprotective effects of Nigella Sativa oil on the formation of stress gastritis in hypothyroidal rats.

Abdel-Sater KA.

Int J Physiol Pathophysiol Pharmacol. 2009 Mar 10;1(2):143-149.

899.

Herbal melanin activates TLR4/NF-kappaB signaling pathway.

Oberg F, Haseeb A, Ahnfelt M, Pontén F, Westermark B, El-Obeid A.

Phytomedicine. 2009 May;16(5):477-84. doi: 10.1016/j.phymed.2008.10.008. Epub 2008 Dec 21.

PMID:
19103478
900.

Effect of different levels of feed added black seed (Nigella sativa L.) on the performance of broiler chicks.

Durrani FR, Chand N, Zaka K, Sultan A, Khattak FM, Durrani Z.

Pak J Biol Sci. 2007 Nov 15;10(22):4164-7.

PMID:
19090301
901.

Thymoquinone protects dopaminergic neurons against MPP+ and rotenone.

Radad K, Moldzio R, Taha M, Rausch WD.

Phytother Res. 2009 May;23(5):696-700. doi: 10.1002/ptr.2708.

PMID:
19089849
902.

Biological activity of seed aqueous extract of Nigella sativa (L.) on germination and seedling growth of Vigna radiata (L.).

Fawzia, Al-Charchafchi MR, Al-Shuhumi H, Al-Meselhy S, Al-Busadi M, Al-Shuhumi H.

Pak J Biol Sci. 2007 Dec 1;10(23):4319-22.

PMID:
19086596
903.

Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats.

Meddah B, Ducroc R, El Abbes Faouzi M, Eto B, Mahraoui L, Benhaddou-Andaloussi A, Martineau LC, Cherrah Y, Haddad PS.

J Ethnopharmacol. 2009 Jan 30;121(3):419-24. doi: 10.1016/j.jep.2008.10.040. Epub 2008 Nov 17.

PMID:
19061948
904.
905.

A new naturally acetylated triterpene saponin from Nigella sativa.

Mehta BK, Mehta P, Gupta M.

Carbohydr Res. 2009 Jan 5;344(1):149-51. doi: 10.1016/j.carres.2008.10.004. Epub 2008 Oct 14.

PMID:
19036356
906.

From here to eternity — the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond.

Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH.

Cancer Ther. 2008;6(b):495-510.

907.

In vitro toxicological properties of thymoquinone.

Khader M, Bresgen N, Eckl PM.

Food Chem Toxicol. 2009 Jan;47(1):129-33. doi: 10.1016/j.fct.2008.10.019. Epub 2008 Oct 29.

PMID:
19010375
909.

[Factors affecting melanogenesis and methods used for identification of pigmentation disorders].

Galus R, Zandecki Ł, Sajjad E, Jóźwiak J, Włodarski K.

Pol Merkur Lekarski. 2008 Aug;25(146):188-91. Review. Polish.

PMID:
18942345
910.

Effect of gamma irradiation on the extraction yield, total phenolic content and free radical-scavenging activity of Nigella staiva seed.

Khattak KF, Simpson TJ, Ihasnullah.

Food Chem. 2008 Oct 15;110(4):967-72. doi: 10.1016/j.foodchem.2008.03.003. Epub 2008 Mar 8.

PMID:
26047287
911.

Effect of thymoquinone on ethylene glycol-induced kidney calculi in rats.

Hadjzadeh MA, Mohammadian N, Rahmani Z, Rassouli FB.

Urol J. 2008 Summer;5(3):149-55.

912.

Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats.

Ebru U, Burak U, Yusuf S, Reyhan B, Arif K, Faruk TH, Emin M, Aydin K, Atilla II, Semsettin S, Kemal E.

Basic Clin Pharmacol Toxicol. 2008 Dec;103(6):574-80. doi: 10.1111/j.1742-7843.2008.00313.x.

913.

Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver.

Yildiz F, Coban S, Terzi A, Ates M, Aksoy N, Cakir H, Ocak AR, Bitiren M.

World J Gastroenterol. 2008 Sep 7;14(33):5204-9.

914.

Antioxidant activities of rosemary (Rosmarinus Officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol.

Erkan N, Ayranci G, Ayranci E.

Food Chem. 2008 Sep 1;110(1):76-82. doi: 10.1016/j.foodchem.2008.01.058. Epub 2008 Feb 6.

PMID:
26050168
915.

Mechanism of in vitro percutaneous absorption enhancement of carvedilol by penetration enhancers.

Amin S, Kohli K, Khar RK, Mir SR, Pillai KK.

Pharm Dev Technol. 2008;13(6):533-9. doi: 10.1080/10837450802309646 .

PMID:
18720242
916.

Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension.

Dehkordi FR, Kamkhah AF.

Fundam Clin Pharmacol. 2008 Aug;22(4):447-52. doi: 10.1111/j.1472-8206.2008.00607.x.

PMID:
18705755
917.

Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways.

Yi T, Cho SG, Yi Z, Pang X, Rodriguez M, Wang Y, Sethi G, Aggarwal BB, Liu M.

Mol Cancer Ther. 2008 Jul;7(7):1789-96. doi: 10.1158/1535-7163.MCT-08-0124.

918.

A study on artifacts formation in the Thai traditional medicine Prasaplai.

Tangyuenyongwatana P, Gritsanapan W.

Planta Med. 2008 Sep;74(11):1403-5. doi: 10.1055/s-2008-1081302. Epub 2008 Jul 11.

PMID:
18622901
919.

Study of protective effect of date and nigella sativa on aflatoxin b(1) toxicity.

Al-Ghasham A, Ata HS, El-Deep S, Meki AR, Shehada S.

Int J Health Sci (Qassim). 2008 Jul;2(2):26-44.

920.

Role of Nigella sativa and a number of its antioxidant constituents towards azoxymethane-induced genotoxic effects and colon cancer in rats.

Al-Johar D, Shinwari N, Arif J, Al-Sanea N, Jabbar AA, El-Sayed R, Mashhour A, Billedo G, El-Doush I, Al-Saleh I.

Phytother Res. 2008 Oct;22(10):1311-23. doi: 10.1002/ptr.2487.

PMID:
18570215